User:Thunderbear65/Developmental plasticity: Difference between revisions
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Another lesser known element of developmental plasticity includes spontaneous bursts of action potentials in developing neural circuits, also referred to as spontaneous network activity. During the early development of neural connections, excitatory synapses undergo spontaneous activation, resulting in elevated intracellular calcium levels that signal the onset of numerous signaling cascades and developmental processes. For example, prior to birth, neural circuits in the retina undergo spontaneous network activity, which has been found to elicit the formation of retinogeniculate connections.<ref>{{cite journal |vauthors=Feller MB |date=April 1999 |title=Spontaneous correlated activity in developing neural circuits |journal=Neuron |volume=22 |issue=4 |pages=653–656 |doi=10.1016/s0896-6273(00)80724-2 |pmid=10230785 |s2cid=18638084 |doi-access=free}}</ref> Developmental spontaneous network activity is also exhibited in the proper formation of [[Neuromuscular junction|neuromuscular circuits]].<ref>{{cite journal |vauthors=Gonzalez-Islas C, Wenner P |date=February 2006 |title=Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength |journal=Neuron |volume=49 |issue=4 |pages=563–575 |doi=10.1016/j.neuron.2006.01.017 |pmid=16476665 |doi-access=free}}</ref> It is believed that spontaneous network activity establishes a scaffold for subsequent learning and information acquisition following the initial establishment of synaptic connections during development. |
Another lesser known element of developmental plasticity includes spontaneous bursts of action potentials in developing neural circuits, also referred to as spontaneous network activity. During the early development of neural connections, excitatory synapses undergo spontaneous activation, resulting in elevated intracellular calcium levels that signal the onset of numerous signaling cascades and developmental processes. For example, prior to birth, neural circuits in the retina undergo spontaneous network activity, which has been found to elicit the formation of retinogeniculate connections.<ref>{{cite journal |vauthors=Feller MB |date=April 1999 |title=Spontaneous correlated activity in developing neural circuits |journal=Neuron |volume=22 |issue=4 |pages=653–656 |doi=10.1016/s0896-6273(00)80724-2 |pmid=10230785 |s2cid=18638084 |doi-access=free}}</ref> Developmental spontaneous network activity is also exhibited in the proper formation of [[Neuromuscular junction|neuromuscular circuits]].<ref>{{cite journal |vauthors=Gonzalez-Islas C, Wenner P |date=February 2006 |title=Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength |journal=Neuron |volume=49 |issue=4 |pages=563–575 |doi=10.1016/j.neuron.2006.01.017 |pmid=16476665 |doi-access=free}}</ref> It is believed that spontaneous network activity establishes a scaffold for subsequent learning and information acquisition following the initial establishment of synaptic connections during development. |
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== Phenotypic plasticity == |
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=== Reaction norms === |
=== Reaction norms === |
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[[File:Trait-scale-norm.png|thumb|Graphical representation of a reaction norm, which determines distribution of potential phenotypes. ]] |
[[File:Trait-scale-norm.png|thumb|Graphical representation of a reaction norm, which determines distribution of potential phenotypes. ]] |
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The norm of reaction, or reaction norm, is a pattern of phenotypic plasticity that describes how a single genotype can produce an array of different phenotypes in response to different environmental conditions.<ref name=":5" /> Furthermore, a reaction norm can be a graphical representation of |
The norm of reaction, or reaction norm, is a pattern of phenotypic plasticity that describes how a single genotype can produce an array of different phenotypes in response to different environmental conditions.<ref name=":5" /> Furthermore, a reaction norm can be a graphical representation of organismal variation in phenotype in response to numerous environmental circumstances. The graphical representation of reaction norms is commonly parabolic in shape, which represents the variation in plasticity across a population.<ref>{{Cite journal |last=Arnold |first=Pieter A. |last2=Kruuk |first2=Loeske E. B. |last3=Nicotra |first3=Adrienne B. |date=2019-05 |title=How to analyse plant phenotypic plasticity in response to a changing climate |url=https://onlinelibrary.wiley.com/doi/10.1111/nph.15656 |journal=New Phytologist |language=en |volume=222 |issue=3 |pages=1235–1241 |doi=10.1111/nph.15656 |issn=0028-646X}}</ref> Additionally, reaction norms allow organisms to evaluate the need for various phenotypes in response to the magnitude of the environmental signal.<ref name=":5" /> |
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=== Polyphenisms === |
=== Polyphenisms === |
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Polyphenism refers to the ability of a single genotype to produce |
Polyphenism refers to the ability of a single genotype to produce a variety of phenotypes in response to different environmental conditions. In contrast to reaction norms, which produce a continuous range of phenotypes, polyphenisms allow a distinct phenotype to arise from altering environmental conditions.<ref>{{Cite web |url=https://academic.oup.com/bioscience/article-lookup/doi/10.2307/1313508 |access-date=2023-03-31 |website=academic.oup.com |doi=10.2307/1313508}}</ref> An example of polyphenism can be seen in the Florida carpenter ant, ''Camponotus floridanus.'' For a developing ant embryo, a multitude of environmental signals can ultimately determine the adult ant morphology. For Florida carpenter ants, the end phenotype and behavior are determined by the morphology; developing ants can either become minor workers, major workers, or queen ants. Although the polyphenism of the ants has been documented, research is still needed to determine the molecular mechanisms for the induction of each unique phenotype.<ref>{{Cite journal |last=Yang |first=Chih-Hsiang |last2=Andrew Pospisilik |first2=John |date=2019-02-26 |title=Polyphenism – A Window Into Gene-Environment Interactions and Phenotypic Plasticity |url=http://dx.doi.org/10.3389/fgene.2019.00132 |journal=Frontiers in Genetics |volume=10 |doi=10.3389/fgene.2019.00132 |issn=1664-8021}}</ref> |
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== Other organisms == |
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=== Environmental cues === |
=== Environmental cues === |
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Environmental cues in either the |
Environmental cues in either the maternal or the embryonic environment can result in changes in the embryo. Embryonic development is a sensitive process and can be impacted by cues from predators,<ref name=":1">{{Cite journal |last=Hales |first=Nicole R. |last2=Schield |first2=Drew R. |last3=Andrew |first3=Audra L. |last4=Card |first4=Daren C. |last5=Walsh |first5=Matthew R. |last6=Castoe |first6=Todd A. |date=2017 |title=Contrasting gene expression programs correspond with predator-induced phenotypic plasticity within and across generations in Daphnia |url=https://onlinelibrary.wiley.com/doi/10.1111/mec.14213 |journal=Molecular Ecology |language=en |volume=26 |issue=19 |pages=5003–5015 |doi=10.1111/mec.14213}}</ref> light,<ref name=":6">{{Cite journal |last=Zambre |first=Amod Mohan |last2=Burns |first2=Linnea |last3=Suresh |first3=Jayanti |last4=Hegeman |first4=Adrian D. |last5=Snell-Rood |first5=Emilie C. |date=2022 |title=Developmental plasticity in multimodal signals: light environment produces novel signalling phenotypes in a butterfly |url=https://royalsocietypublishing.org/doi/10.1098/rsbl.2022.0099 |journal=Biology Letters |language=en |volume=18 |issue=8 |pages=20220099 |doi=10.1098/rsbl.2022.0099 |issn=1744-957X |pmc=PMC9382452 |pmid=35975631}}</ref> and/or temperature.<ref name=":2">{{Cite journal |last=Bock |first=Samantha L. |last2=Smaga |first2=Christopher R. |last3=McCoy |first3=Jessica A. |last4=Parrott |first4=Benjamin B. |date=2022 |title=Genome‐wide DNA methylation patterns harbour signatures of hatchling sex and past incubation temperature in a species with environmental sex determination |url=https://onlinelibrary.wiley.com/doi/10.1111/mec.16670 |journal=Molecular Ecology |language=en |volume=31 |issue=21 |pages=5487–5505 |doi=10.1111/mec.16670 |issn=0962-1083 |pmc=PMC9826120 |pmid=35997618}}</ref> For example, in ''[[Daphnia]]'', neonates exposed to predator cues displayed higher expression of genes related to digestion, reproductive function, and defense. It was hypothesized that this increase in gene expression would allow the ''Daphnia'' to defend themselves and that an increase in growth would result in a larger investment in future offspring. Subsequent generations exhibited a similar pattern, despite not being exposed to any predator cues, suggesting an [[Transgenerational epigenetic inheritance|inheritance]] of [[Epigenetics|epigenetic]] expression factors.<ref name=":1" /> An organism's sensitivity to light during development could be useful in predicting what phenotype may be the most beneficial in the future based on the foliage of the mature organism.<ref name=":6" /> Several species, including [[Alligator|alligators]] and [[Tortoise|tortoises]], have [[temperature-dependent sex determination]], where the sex of the organism is dependent on the environmental temperature during a crucial thermosensitive period. An active area of research involves the mechanisms of temperature sex determination, which have been hypothesized to be associated with the [[methylation]] of specific genes.<ref name=":2" /> |
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=== References === |
=== References === |
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Lead
Regarding humans, developmental plasticity is a general term referring to changes in neural connections during development as a result of environmental interactions as well as neural changes induced by learning.[2] Much like neuroplasticity, or brain plasticity, developmental plasticity is specific to the change in neurons and synaptic connections as a consequence of developmental processes. A child creates most of these connections from birth to early childhood. There are three primary methods by which this may occur as the brain develops,[3] but critical periods determine when lasting changes may form. Developmental plasticity may also be used in place of the term phenotypic plasticity when an organism in an embryonic or larval stage can alter its phenotype based on environmental factors.[1] However, a main difference between the two is that phenotypic plasticity experienced during adulthood can be reversible, whereas traits that are considered developmentally plastic set foundations during early development that remain throughout the life of the organism.[4]
Article body
Mechanisms
During development, the central nervous system acquires information via endogenous or exogenous factors as well as learning experiences. In acquiring and storing such information, the plastic nature of the central nervous system allows for the adaptation of existing neural connections in order to accommodate new information and experiences, resulting in developmental plasticity. This form of plasticity that occurs during development is the result of three predominant mechanisms: synaptic and homeostatic plasticity, and learning.[3]
Synaptic plasticity
The underlying principle of synaptic plasticity is that synapses undergo an activity-dependent and selective strengthening or weakening so that new information can be stored.[5][6] Synaptic plasticity depends on numerous factors including the threshold of the presynaptic stimulus in addition to the relative concentrations of neurotransmitter molecules. Synaptic plasticity has long been implicated for its role in memory storage and is thought to play a key role in learning.[7][6] However, during developmental periods, synaptic plasticity is of particular importance, as changes in the network of synaptic connections can ultimately lead to changes in developmental milestones. For instance, the initial overproduction of synapses during development is key to plasticity that occurs in the visual and auditory cortices.[8] In experiments conducted by Hubel and Wiesel, the visual cortex of kittens exhibits synaptic plasticity in the refinement of neural connections following visual inputs. Correspondingly, in the absence of such inputs during development, the visual field fails to develop properly and can lead to abnormal structures and behavior.[9] Furthermore, research suggests that this initial overproduction of synapses during developmental periods provides the foundation by which many synaptic connections can be formed, thus resulting in more synaptic plasticity. In the same way that synapses are abundant during development, there are also refining mechanisms that assist in the maturation of synapses in neural circuits. This regulatory process allows the strengthening of important or frequently used synaptic connections while reducing the amount of weak connections.[10]
Homeostatic plasticity
In order to maintain balance, homeostatic controls exist to regulate the overall activity of neural circuits, specifically by regulating the destabilizing effects of developmental and learning processes that result in changes of synaptic strength. Homeostatic plasticity also helps regulate prolonged excitatory responses, which lead to a reduction in all of a neuron's synaptic responses.[11] Numerous pathways have recently been associated with homeostatic plasticity, though there is still no clear molecular mechanism. Synaptic scaling is one method that serves as a type of autoregulation, as neurons can recognize their own firing rates and notice when there are alterations; calcium-dependent signals control the levels of glutamate receptors at synaptic sites in response. Homeostatic mechanisms may be local or network-wide.[12]
Learning
While synaptic plasticity is considered to be a by-product of learning, learning involves interaction with the environment to acquire the new information or behavior; synaptic plasticity merely represents the change in strength or configuration of neural circuits.[13] Learning is crucial, as there is considerable interaction with the environment, which is when the potential for acquiring new information is greatest. By depending largely upon selective experiences, neural connections are altered and strengthened in a manner that is unique to those experiences.[14] Experimentally, this can be seen when rats are raised in an environment that allows ample social interaction, resulting in increased brain weight and cortical thickness. In contrast, the inverse is seen following rearing in an environment devoid of interaction.[15] Also, learning plays a considerable role in the selective acquisition of information and is markedly demonstrated when children develop one language instead of another. Another example of such experience-dependent plasticity that is critical during development is the occurrence of imprinting. This occurs as a result of a young child or animal being exposed to a novel stimulus and rapidly implementing a certain behavior in response.[16]
Neural development
The formation of the nervous system is one of the most crucial events in the developing embryo. The differentiation of stem cell precursors into specialized neurons gives rise to the formation of synapses and neural circuits, which is key to the principle of plasticity.[17] During this pivotal point in development, consequent developmental processes like the differentiation and specialization of neurons are highly sensitive to exogenous and endogenous factors.[18] For example, in utero exposure to nicotine has been linked to adverse effects, such as severe physical and cognitive deficits, due to the impediment of the normal acetylcholine receptor activation. In a recent study, the connection between such nicotine exposure and prenatal development was assessed. It was determined that nicotine exposure in early development can have a lasting and encompassing effect on neuronal structures, underlying the behavioral and cognitive defects observed in exposed humans and animals. Additionally, when proper synaptic function is disrupted through nicotine exposure, the overall circuit may become less sensitive and responsive to stimuli, resulting in compensatory developmental plasticity.[19] It is for this reason that exposure to various environmental factors during developmental periods can cause profound effects on subsequent neural functioning.
Neural refinement and connectivity
Initial stages of neural development begin early on in the fetus with spontaneous firing of the developing neuron.[20] These early connections are weak and often overlap at the terminal ends of the arbors.[21] The young neurons have complete potential of changing morphology during a time span classified as the critical period to achieve strengthened and refined synaptic connections. It is during this time that damaged neuronal connections can become functionally recovered. Large alterations in length and location of these neurons can occur until synaptic circuitry is further defined.[22] Although organization of neural connections begins at the earliest stages of development, activity-driven refinement only begins at birth when the individual neurons can be recognized as separate entities and start to enhance in specificity.[23] The gradual pruning of the initially blurry axonal branching occurs via competitive and facilitative mechanisms, relying on electrical activity at the synapses; axons that fire independently of each other tend to compete for territory, whereas axons that synchronously fire mutually amplify connections.[24] Until this architecture has been established, retinal focus remains diffuse. Perpetuation of these newly formed connections or the lack thereof depends on maintenance of electrical activities at the synapses. Upon refinement, the elaborate connections narrow and strengthen to fire only in response to specific stimuli to optimize visual acuity.[25] These mechanisms can malfunction with the introduction of toxins, which bind to sodium channels and suppress action potentials and consequently electrical activity between synapses.[26]
Quantification of synaptic networks has primarily been through retinal wave detection using Ca2+ fluorescent indicators. Prior to birth, retinal waves are seen to originate as clusters that propagate through the refractory region. These assays have been shown to provide spatiotemporal data on the random bursts of action potentials produced in a refractory period.[27] Another assay recently developed to assess the depth of neuronal connections utilizes the trans-neuronal spread of rabies.[28] This method of tracing employs the migration of a neurotropic virus through tightly interconnected neurons and specific site labeling of distinct connections.[29] Patch-clamping experiments and calcium imaging are often conducted based on preliminary results from this assay in order to detect spontaneous neuronal activity.[30] A method for in vitro synaptic quantification has been developed that uses immunofluorescence to measure synaptic density in different cell cultures.[31]
Critical period
The concept of critical periods is a widely accepted and prominent theme in development, with strong implications for developmental plasticity. Critical periods establish a time frame in which the shaping of neural networks can be carried out. During these critical periods in development, plasticity occurs as a result of changes in the structure or function of developing neural circuits. Such critical periods can also be experience-dependent, in the instance of learning via new experiences, or can be independent of the environmental experience and rely on biological mechanisms including endogenous or exogenous factors.[32] Some of the most pervading examples of this can be seen through the development of the visual cortex in addition to the acquisition of language as a result of developmental plasticity during the critical period.[9][33] A lesser known example, however, remains the critical development of respiratory control during developmental periods. At birth, the development of respiratory control neural circuits is incomplete, requiring complex interactions from both the environment and intrinsic factors. Experimentally exposing two-week-old kittens and rats to hyperoxic conditions completely eliminates the carotid chemoreceptor response to hypoxia, resulting in respiratory impairment. This has remarkable clinical significance, as newborn infants are often supplemented with considerable amounts of oxygen, which could detrimentally affect the way in which neural circuits for respiratory control develop during the critical period. When stimuli appear or experiences occur outside of the critical period, any potential outcome is typically not long-lasting.[34]
Spontaneous network activity
Another lesser known element of developmental plasticity includes spontaneous bursts of action potentials in developing neural circuits, also referred to as spontaneous network activity. During the early development of neural connections, excitatory synapses undergo spontaneous activation, resulting in elevated intracellular calcium levels that signal the onset of numerous signaling cascades and developmental processes. For example, prior to birth, neural circuits in the retina undergo spontaneous network activity, which has been found to elicit the formation of retinogeniculate connections.[35] Developmental spontaneous network activity is also exhibited in the proper formation of neuromuscular circuits.[36] It is believed that spontaneous network activity establishes a scaffold for subsequent learning and information acquisition following the initial establishment of synaptic connections during development.
Phenotypic plasticity
Reaction norms
The norm of reaction, or reaction norm, is a pattern of phenotypic plasticity that describes how a single genotype can produce an array of different phenotypes in response to different environmental conditions.[1] Furthermore, a reaction norm can be a graphical representation of organismal variation in phenotype in response to numerous environmental circumstances. The graphical representation of reaction norms is commonly parabolic in shape, which represents the variation in plasticity across a population.[37] Additionally, reaction norms allow organisms to evaluate the need for various phenotypes in response to the magnitude of the environmental signal.[1]
Polyphenisms
Polyphenism refers to the ability of a single genotype to produce a variety of phenotypes in response to different environmental conditions. In contrast to reaction norms, which produce a continuous range of phenotypes, polyphenisms allow a distinct phenotype to arise from altering environmental conditions.[38] An example of polyphenism can be seen in the Florida carpenter ant, Camponotus floridanus. For a developing ant embryo, a multitude of environmental signals can ultimately determine the adult ant morphology. For Florida carpenter ants, the end phenotype and behavior are determined by the morphology; developing ants can either become minor workers, major workers, or queen ants. Although the polyphenism of the ants has been documented, research is still needed to determine the molecular mechanisms for the induction of each unique phenotype.[39]
Environmental cues
Environmental cues in either the maternal or the embryonic environment can result in changes in the embryo. Embryonic development is a sensitive process and can be impacted by cues from predators,[40] light,[41] and/or temperature.[42] For example, in Daphnia, neonates exposed to predator cues displayed higher expression of genes related to digestion, reproductive function, and defense. It was hypothesized that this increase in gene expression would allow the Daphnia to defend themselves and that an increase in growth would result in a larger investment in future offspring. Subsequent generations exhibited a similar pattern, despite not being exposed to any predator cues, suggesting an inheritance of epigenetic expression factors.[40] An organism's sensitivity to light during development could be useful in predicting what phenotype may be the most beneficial in the future based on the foliage of the mature organism.[41] Several species, including alligators and tortoises, have temperature-dependent sex determination, where the sex of the organism is dependent on the environmental temperature during a crucial thermosensitive period. An active area of research involves the mechanisms of temperature sex determination, which have been hypothesized to be associated with the methylation of specific genes.[42]
References
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{{cite book}}: CS1 maint: location missing publisher (link) - ^ Kolb, Bryan; Gibb, Robbin (2011). "Brain plasticity and behaviour in the developing brain". Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal De l'Academie Canadienne De Psychiatrie De L'enfant Et De L'adolescent. 20 (4): 265–276. ISSN 2293-6122. PMC 3222570. PMID 22114608.
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{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Lafuente, Elvira; Beldade, Patrícia (2019). "Genomics of Developmental Plasticity in Animals". Frontiers in Genetics. 10. doi:10.3389/fgene.2019.00720. ISSN 1664-8021. PMC 6709652. PMID 31481970.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Foehring RC, Lorenzon NM (March 1999). "Neuromodulation, development and synaptic plasticity". Canadian Journal of Experimental Psychology. 53 (1): 45–61. doi:10.1037/h0087299. PMID 10389489.
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{{cite journal}}: CS1 maint: PMC format (link) - ^ Bennett EL, Diamond MC, Krech D, Rosenzweig MR (October 1964). "Chemical and Anatomical Plasticity of Brain". Science. 146 (3644): 610–619. Bibcode:1964Sci...146..610B. doi:10.1126/science.146.3644.610. PMID 14191699.
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{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Principles of neural science. Eric R. Kandel, James H. Schwartz, Thomas M. Jessell (4th ed.). New York: McGraw-Hill, Health Professions Division. 2000. ISBN 0-8385-7701-6. OCLC 42073108.
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{{cite journal}}: CS1 maint: PMC format (link) - ^ Tao, Huizhong W.; Poo, Mu-ming (2005-03-24). "Activity-Dependent Matching of Excitatory and Inhibitory Inputs during Refinement of Visual Receptive Fields". Neuron. 45 (6): 829–836. doi:10.1016/j.neuron.2005.01.046. ISSN 0896-6273. PMID 15797545.
- ^ Cancedda, Laura; Poo, Mu-Ming (2009), Binder, Marc D.; Hirokawa, Nobutaka; Windhorst, Uwe (eds.), "Synapse Formation and Elimination: Competition and the Role of Activity", Encyclopedia of Neuroscience, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 3932–3938, doi:10.1007/978-3-540-29678-2_5800, ISBN 978-3-540-23735-8, retrieved 2023-03-25
- ^ Demb, Jonathan B.; Singer, Joshua H. (2015-11-24). "Functional Circuitry of the Retina". Annual Review of Vision Science. 1 (1): 263–289. doi:10.1146/annurev-vision-082114-035334. ISSN 2374-4642. PMC 5749398. PMID 28532365.
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- ^ Ugolini G (2011). "Rabies virus as a transneuronal tracer of neuronal connections". Advances in Virus Research. 79: 165–202. doi:10.1016/B978-0-12-387040-7.00010-X. ISBN 9780123870407. PMID 21601048.
- ^ Belinsky GS, Rich MT, Sirois CL, Short SM, Pedrosa E, Lachman HM, Antic SD (January 2014). "Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons". Stem Cell Research. 12 (1): 101–118. doi:10.1016/j.scr.2013.09.014. PMC 3947234. PMID 24157591.
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