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Functional seizures have been found to be as disabling and costly as epilepsy.<ref>{{Cite journal |last=Asadi-Pooya |first=Ali A. |last2=Brigo |first2=Francesco |last3=Tolchin |first3=Benjamin |last4=Valente |first4=Kette D. |date=2021 |title=Functional seizures are not less important than epilepsy |url=https://pubmed.ncbi.nlm.nih.gov/34805820 |journal=Epilepsy & Behavior Reports |volume=16 |pages=100495 |doi=10.1016/j.ebr.2021.100495 |issn=2589-9864 |pmc=8585631 |pmid=34805820}}</ref> Though there is limited evidence, outcomes appear to be relatively poor with a review of outcome studies finding that two-thirds of people with PNES continue to experience episodes and more than half are dependent on the Social Security program at three-year follow-up.<ref name=Reuber>{{cite journal | vauthors = Reuber M, Elger CE | title = Psychogenic nonepileptic seizures: review and update | journal = Epilepsy & Behavior | volume = 4 | issue = 3 | pages = 205–16 | date = June 2003 | pmid = 12791321 | doi = 10.1016/S1525-5050(03)00104-5 | s2cid = 25347605 }}</ref> This outcome data was obtained in a referral-based academic epilepsy center and loss to follow-up was considerable; the authors point out ways in which this may have biased their outcome data. Outcome was shown to be better in people with higher IQ,<ref>{{cite journal | vauthors = McDade G, Brown SW | title = Non-epileptic seizures: management and predictive factors of outcome | journal = Seizure | volume = 1 | issue = 1 | pages = 7–10 | date = March 1992 | pmid = 1344323 | doi = 10.1016/1059-1311(92)90047-5 | s2cid = 7123910 }}</ref> social status,<ref>{{cite journal | vauthors = Kanner AM, Parra J, Frey M, Stebbins G, Pierre-Louis S, Iriarte J | title = Psychiatric and neurologic predictors of psychogenic pseudoseizure outcome | journal = Neurology | volume = 53 | issue = 5 | pages = 933–8 | date = September 1999 | pmid = 10496249 | doi = 10.1212/wnl.53.5.933 | s2cid = 37244184 }}</ref> greater educational attainments,<ref name=ReuberAnnals>{{cite journal | vauthors = Reuber M, Pukrop R, Bauer J, Helmstaedter C, Tessendorf N, Elger CE | title = Outcome in psychogenic nonepileptic seizures: 1 to 10-year follow-up in 164 patients | journal = Annals of Neurology | volume = 53 | issue = 3 | pages = 305–11 | date = March 2003 | pmid = 12601698 | doi = 10.1002/ana.3000 | s2cid = 22463051 }}</ref> younger age of onset and diagnosis,<ref name=ReuberAnnals /> attacks with less dramatic features,<ref name=ReuberAnnals /> and fewer additional somatoform complaints.<ref name=ReuberAnnals />
Functional seizures have been found to be as disabling and costly as epilepsy.<ref>{{Cite journal |last=Asadi-Pooya |first=Ali A. |last2=Brigo |first2=Francesco |last3=Tolchin |first3=Benjamin |last4=Valente |first4=Kette D. |date=2021 |title=Functional seizures are not less important than epilepsy |url=https://pubmed.ncbi.nlm.nih.gov/34805820 |journal=Epilepsy & Behavior Reports |volume=16 |pages=100495 |doi=10.1016/j.ebr.2021.100495 |issn=2589-9864 |pmc=8585631 |pmid=34805820}}</ref> Though there is limited evidence, outcomes appear to be relatively poor with a review of outcome studies finding that two-thirds of people with PNES continue to experience episodes and more than half are dependent on the Social Security program at three-year follow-up.<ref name=Reuber>{{cite journal | vauthors = Reuber M, Elger CE | title = Psychogenic nonepileptic seizures: review and update | journal = Epilepsy & Behavior | volume = 4 | issue = 3 | pages = 205–16 | date = June 2003 | pmid = 12791321 | doi = 10.1016/S1525-5050(03)00104-5 | s2cid = 25347605 }}</ref> This outcome data was obtained in a referral-based academic epilepsy center and loss to follow-up was considerable; the authors point out ways in which this may have biased their outcome data. Outcome was shown to be better in people with higher IQ,<ref>{{cite journal | vauthors = McDade G, Brown SW | title = Non-epileptic seizures: management and predictive factors of outcome | journal = Seizure | volume = 1 | issue = 1 | pages = 7–10 | date = March 1992 | pmid = 1344323 | doi = 10.1016/1059-1311(92)90047-5 | s2cid = 7123910 }}</ref> social status,<ref>{{cite journal | vauthors = Kanner AM, Parra J, Frey M, Stebbins G, Pierre-Louis S, Iriarte J | title = Psychiatric and neurologic predictors of psychogenic pseudoseizure outcome | journal = Neurology | volume = 53 | issue = 5 | pages = 933–8 | date = September 1999 | pmid = 10496249 | doi = 10.1212/wnl.53.5.933 | s2cid = 37244184 }}</ref> greater educational attainments,<ref name=ReuberAnnals>{{cite journal | vauthors = Reuber M, Pukrop R, Bauer J, Helmstaedter C, Tessendorf N, Elger CE | title = Outcome in psychogenic nonepileptic seizures: 1 to 10-year follow-up in 164 patients | journal = Annals of Neurology | volume = 53 | issue = 3 | pages = 305–11 | date = March 2003 | pmid = 12601698 | doi = 10.1002/ana.3000 | s2cid = 22463051 }}</ref> younger age of onset and diagnosis,<ref name=ReuberAnnals /> attacks with less dramatic features,<ref name=ReuberAnnals /> and fewer additional somatoform complaints.<ref name=ReuberAnnals />


For individuals who pursue treatment for PNES, CBT has shown varying rates of success but it has been established as one of the most promising treatments to date.<ref>{{cite journal | vauthors = Kamil SH, Qureshi M, Patel RS | title = Cognitive Behavioral Therapy (CBT) in Psychogenic Non-Epileptic Seizures (PNES): A Case Report and Literature Review | journal = Behavioral Sciences | volume = 9 | issue = 2 | pages = 15 | date = January 2019 | pmid = 30699899 | pmc = 6406384 | doi = 10.3390/bs9020015 | doi-access = free }}</ref> ReACT has shown reduction in symptoms by 100% seven days after treatment and 82% of individuals who completed the therapy remained symptom free for 60 days. A follow-up has not been done to see if the therapy retained its reduction of symptoms beyond the 60 days.<ref name=":2" /> In the Cognitive behavioural therapy for adults with dissociative seizures (CODES) trial, he largest regarding CBT treatment for PNES though found no significant reduction in monthly seizures compared to the control arm at 12 months, however there were significant improvements on a number of secondary outcomes, such as psychosocial functioning, and self-rated and clinician-rated global change.<ref>{{Cite journal |last1=Goldstein |first1=Laura H. |last2=Robinson |first2=Emily J. |last3=Mellers |first3=John D. C. |last4=Stone |first4=Jon |last5=Carson |first5=Alan |last6=Reuber |first6=Markus |last7=Medford |first7=Nick |last8=McCrone |first8=Paul |last9=Murray |first9=Joanna |last10=Richardson |first10=Mark P. |last11=Pilecka |first11=Izabela |date=2020-06-01 |title=Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial |journal=The Lancet Psychiatry |language=English |volume=7 |issue=6 |pages=491–505 |doi=10.1016/S2215-0366(20)30128-0 |issn=2215-0366 |pmid=32445688|pmc=7242906 }}</ref> A secondary analysis of the CODES trial demonstrated improved frequency of functional seizures at 6 months with CBT.
For individuals who pursue treatment for PNES, CBT has shown varying rates of success but it has been established as one of the most promising treatments to date.<ref>{{cite journal | vauthors = Kamil SH, Qureshi M, Patel RS | title = Cognitive Behavioral Therapy (CBT) in Psychogenic Non-Epileptic Seizures (PNES): A Case Report and Literature Review | journal = Behavioral Sciences | volume = 9 | issue = 2 | pages = 15 | date = January 2019 | pmid = 30699899 | pmc = 6406384 | doi = 10.3390/bs9020015 | doi-access = free }}</ref> ReACT has shown reduction in symptoms by 100% seven days after treatment and 82% of individuals who completed the therapy remained symptom free for 60 days. A follow-up has not been done to see if the therapy retained its reduction of symptoms beyond the 60 days.<ref name=":2" /> In the Cognitive behavioural therapy for adults with dissociative seizures (CODES) trial, the largest regarding CBT treatment for PNES though found no significant reduction in monthly seizures compared to the control arm at 12 months, however there were significant improvements on a number of secondary outcomes, such as psychosocial functioning, and self-rated and clinician-rated global change.<ref>{{Cite journal |last1=Goldstein |first1=Laura H. |last2=Robinson |first2=Emily J. |last3=Mellers |first3=John D. C. |last4=Stone |first4=Jon |last5=Carson |first5=Alan |last6=Reuber |first6=Markus |last7=Medford |first7=Nick |last8=McCrone |first8=Paul |last9=Murray |first9=Joanna |last10=Richardson |first10=Mark P. |last11=Pilecka |first11=Izabela |date=2020-06-01 |title=Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial |journal=The Lancet Psychiatry |language=English |volume=7 |issue=6 |pages=491–505 |doi=10.1016/S2215-0366(20)30128-0 |issn=2215-0366 |pmid=32445688|pmc=7242906 }}</ref> A secondary analysis of the CODES trial demonstrated improved frequency of functional seizures at 6 months with CBT.


==History==
==History==

Revision as of 03:53, 2 June 2023

Psychogenic non-epileptic seizures
Other namespseudoseizures, dissociative non-epileptic seizures, FNEA (Functional Non-Epileptic Attacks), NEAD (Non-epileptic Attack Disorder)[1]
SpecialtyNeurology, psychiatry

Psychogenic non-epileptic seizures (PNES) (more recently classified as functional seizures) or non-epileptic seizures) are events resembling an epileptic seizure, but without the characteristic electrical discharges associated with epilepsy.[2][3] PNES fall under the category of disorders known as functional neurological disorders (FND), also known as conversion disorders.[4] A more recent term to describe these events is dissociative non-epileptic seizures.[5] These are typically treated by psychologists or psychiatrists. PNES has previously been called pseudoseizures, psychogenic seizures, and hysterical seizures, but these terms have fallen out of favor.[6]

Incidence

The number of people with PNES ranges from 2 to 33 per 100,000.[7] PNES are most common in young adults, particularly women.[7] The prevalence for PNES is estimated to make up 5–20% of outpatient epilepsy clinics; 75–80% of these diagnoses are given to female patients and 83% are to individuals between 15 and 35 years old.[8]

Children

PNES are seen in children after the age of eight, and occur equally among boys and girls before puberty. Diagnostic and treatment principles are similar to those for adults, except that in children there is a broader differential diagnosis of seizures so that other possible diagnoses specific to children may be considered.[9]

Signs and symptoms

Individuals with PNES present with episodes that resemble epileptic seizures, and most have received a diagnosis of epilepsy and treatment for it.[10][11][12][13] PNES episodes are nearly indistinguishable from epileptic seizures. The main differences between a PNES episode and an epileptic seizure is the duration of episodes. Epileptic seizures typically last between 30 and 120 seconds depending on the type, while PNES episodes typically last for two to five minutes.[14]

Causes and risk factors

The cause of PNES has not yet been established. One hypothesis is that they are a learned physical reaction or habit the body develops, similar to a reflex. The individual does not have control of the learned reaction, but this can be retrained to allow the patient to control the physical movements again.[13] The production of seizure-like symptoms is not under voluntary control, meaning that the person is not faking;[10][15] symptoms which are feigned or faked voluntarily would fall under the categories of factitious disorder or malingering.[16]

Risk factors for PNES include having a history of head injury, and having a diagnosis of epilepsy.[17] Approximately 10–30% of people diagnosed with PNES also have an epilepsy diagnosis. People diagnosed with PNES commonly report physical, sexual, or emotional trauma, but the reported incidence of these events may not differ between PNES and epilepsy.[18]

Diagnosis

According to the Diagnostic and Statistical Manual of Mental Disorders (version 5) the criteria for receiving a diagnosis of PNES are:[19]

  1. One or more symptoms of altered voluntary motor or sensory function.
  2. Clinical findings provide evidence of incompatibility between the symptom and recognized neurological or medical conditions.
  3. The symptom or deficit is not better explained by another medical or mental disorder.
  4. The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning or warrants medical evaluation.

Additionally, the specific symptom type must be reported "with attacks or seizures".[19]

Some individuals with PNES have carried an erroneous diagnosis of epilepsy. On average, it takes seven years to receive a proper diagnosis. The differential diagnosis of PNES firstly involves ruling out epilepsy as the cause of the seizure episodes, along with other organic causes of non-epileptic seizures, including syncope, migraine, vertigo, anoxia, hypoglycemia, and stroke. However, 5–20% of people with PNES also have epilepsy.[20] Frontal lobe seizures can be mistaken for PNES, though these tend to have shorter duration, stereotyped patterns of movements, and occurrence during sleep.[21] Next, an exclusion of factitious disorder (a subconscious somatic symptom disorder, where seizures are caused by psychological reasons) and malingering (simulating seizures intentionally for conscious personal gain – such as monetary compensation or avoidance of criminal punishment) is conducted. Finally other psychiatric conditions that may superficially resemble seizures are eliminated, including panic disorder, schizophrenia, and depersonalisation disorder.[21]

The most definitive test to distinguish epilepsy from PNES is long term video-EEG monitoring, with the aim of capturing one or two episodes on both video recording and EEG simultaneously (some clinicians may use suggestion to attempt to trigger an episode).[22] Additional clinical criteria are usually considered in addition to video-EEG monitoring when diagnosing PNES.[23] By recording the event in question on video and EEG simultaneously, a clear diagnosis can usually be obtained.[24]

Laboratory testing can detect rising blood levels of serum prolactin if samples are taken in the right time window after most tonic-clonic or complex partial epileptic seizures. However, due to false positives and variability in results, this test is relied upon less frequently.[21]

Distinguishing features

Some features are more or less likely to suggest PNES but they are not conclusive and should be considered in the broader clinical picture. Features that are common in PNES but rarer in epilepsy include: biting the tip of the tongue, seizures lasting more than two minutes (easiest factor to distinguish), seizures having a gradual onset, a fluctuating course of disease severity, the eyes being closed during a seizure, and side to side head movements. Features that are uncommon in PNES include automatisms (automatic complex movements during the seizure), severe tongue biting, biting the inside of the mouth, and incontinence.[21]

If a person with suspected PNES has an episode during a clinical examination, there are a number of signs that can be elicited to help support or refute the diagnosis of PNES. Compared to people with epilepsy, people with PNES will tend to resist having their eyes forced open (if they are closed during the seizure), will stop their hands from hitting their own face if the hand is dropped over the head, and will fixate their eyes in a way suggesting an absence of neurological interference.[21]

Treatment

Patient understanding of the new diagnosis is crucial for their treatment, which requires their active participation.[25] There are a number of recommended steps to explain to people their diagnosis in a sensitive and open manner. A negative diagnosis experience may cause frustration and could cause a person to reject any further attempts at treatment. Eight points recommended to explain the diagnosis to the person and their caregivers are:

  1. Reasons for concluding they do not have epilepsy
  2. What they do have (describe FND)
  3. Emphasize they are not suspected of "putting on" the attacks, and the symptoms are not "all in their head"
  4. There may be no triggering "stresses"
  5. Maintaining factors
  6. May improve after correct diagnosis
  7. Caution that anticonvulsant drug withdrawal should be done in conjunction with their physician
  8. Describe treatment to help regain control of symptoms

Psychotherapy is the most frequently used treatment, which might include cognitive behavioral therapy or therapy to retrain the physical symptoms and allow the individual to regain control of the attacks (ReACT). There is also some evidence supporting selective serotonin reuptake inhibitor antidepressants.[26]

Cognitive behavioral therapy[27]

Cognitive behavioral therapy (CBT) treatments for PNES typically target fear avoidance and work to reattribute patients' symptoms to psychosocial issues.

Retraining and Control Therapy (ReACT)

ReACT, while new and understudied, has shown extremely promising outcomes for reduction of PNES episodes in pediatric patients.[28] This therapy focuses on the idea that PNES are caused by a learned physical reaction or habit the body develops, similar to a reflex. ReACT aims to retrain the learned reaction (PNES episodes) by targeting symptom catastrophizing and restoring sense of control over symptoms.

Prognosis

Functional seizures have been found to be as disabling and costly as epilepsy.[29] Though there is limited evidence, outcomes appear to be relatively poor with a review of outcome studies finding that two-thirds of people with PNES continue to experience episodes and more than half are dependent on the Social Security program at three-year follow-up.[25] This outcome data was obtained in a referral-based academic epilepsy center and loss to follow-up was considerable; the authors point out ways in which this may have biased their outcome data. Outcome was shown to be better in people with higher IQ,[30] social status,[31] greater educational attainments,[32] younger age of onset and diagnosis,[32] attacks with less dramatic features,[32] and fewer additional somatoform complaints.[32]

For individuals who pursue treatment for PNES, CBT has shown varying rates of success but it has been established as one of the most promising treatments to date.[33] ReACT has shown reduction in symptoms by 100% seven days after treatment and 82% of individuals who completed the therapy remained symptom free for 60 days. A follow-up has not been done to see if the therapy retained its reduction of symptoms beyond the 60 days.[28] In the Cognitive behavioural therapy for adults with dissociative seizures (CODES) trial, the largest regarding CBT treatment for PNES though found no significant reduction in monthly seizures compared to the control arm at 12 months, however there were significant improvements on a number of secondary outcomes, such as psychosocial functioning, and self-rated and clinician-rated global change.[34] A secondary analysis of the CODES trial demonstrated improved frequency of functional seizures at 6 months with CBT.

History

Hystero-epilepsy is a historical term that refers to a condition described by 19th-century French neurologist Jean-Martin Charcot[35] where people with neuroses "acquired" symptoms resembling seizures as a result of being treated on the same ward as people who genuinely had epilepsy.

The etiology of FND was historically explained in the context of psychoanalytic theory as a physical manifestation of psychological distress and repressed trauma. There is very little supporting evidence for this theory, as there is little research.[36]

The DSM-IV lists conversion disorders instead of the current FND. Additionally, in revision, the DSM-5 was updated to add emphasis to the positive physical signs inconsistent with recognized diseases. The requirement of a history of psychological stressors and that the symptom is not fake was removed as well.[37]

Society and culture

PNES rates and presenting symptoms are somewhat dependent on the culture and society. In some cultures, they, like epilepsy, are thought of as a curse or a demonic possession.[38] In cultures with a solid establishment of evidence-based medicine, they are considered a subtype of a larger category of psychiatric disease.

Terminology

The use of older terms including pseudoseizures and hysterical seizures are discouraged.[39] In the English language, the word "seizure" usually refers to epileptic events, so some prefer to use more general terms like "events", "attacks", or "episodes", as the term "seizures" may cause confusion with epilepsy.[40][41]

PNES may also be referred to as "non-epileptic attack disorder" "functional seizures", "dissociative convulsions" or "dissociative non-epileptic seizures". These terms are more neutral as to cause, and given that a psychological cause cannot be identified in many cases, they may be more appropriate. Within DSM 5, patients presenting with PNES may meet the criteria for functional neurological disorder and in some cases, somatic symptom disorder, whilst in ICD 10 it may meet the criteria for a conversion disorder.[21]

References

  1. ^ "Behandling av psykogena icke-epileptiska anfall". www.sbu.se (in Swedish). 2022-02-15. Retrieved 2022-12-10. {{cite web}}: |first= missing |last= (help)[author missing]
  2. ^ Devinsky O, Gazzola D, LaFrance WC (April 2011). "Differentiating between nonepileptic and epileptic seizures". Nature Reviews. Neurology. 7 (4): 210–20. doi:10.1038/nrneurol.2011.24. PMID 21386814. S2CID 25493204.
  3. ^ Ertan, Deniz; Aybek, Selma; LaFrance, W. Curt; Kanemoto, Kousuke; Tarrada, Alexis; Maillard, Louis; El-Hage, Wissam; Hingray, Coraline (February 2022). "Functional (psychogenic non-epileptic/dissociative) seizures: why and how?". Journal of Neurology, Neurosurgery, and Psychiatry. 93 (2): 144–157. doi:10.1136/jnnp-2021-326708. ISSN 1468-330X. PMID 34824146.
  4. ^ Huff, J. Stephen; Murr, Najib (2023), "Psychogenic Nonepileptic Seizures", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 28722901, retrieved 2023-05-05
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  6. ^ Huff, J. Stephen; Murr, Najib (2021), "Psychogenic Nonepileptic Seizures", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 28722901, archived from the original on 2021-11-20, retrieved 2021-12-03
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  13. ^ a b Fobian AD, Elliott L (January 2019). "A review of functional neurological symptom disorder etiology and the integrated etiological summary model". Journal of Psychiatry & Neuroscience. 44 (1): 8–18. doi:10.1503/jpn.170190. PMC 6306282. PMID 30565902.
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  21. ^ a b c d e f Mellers JD (August 2005). "The approach to patients with "non-epileptic seizures"". Postgraduate Medical Journal. 81 (958): 498–504. doi:10.1136/pgmj.2004.029785. PMC 1743326. PMID 16085740.
  22. ^ Asano E, Pawlak C, Shah A, Shah J, Luat AF, Ahn-Ewing J, Chugani HT (2005). "The diagnostic value of initial video-EEG monitoring in children—review of 1000 cases". Epilepsy Research. 66 (1–3): 129–35. doi:10.1016/j.eplepsyres.2005.07.012. PMID 16157474. S2CID 22132928.
  23. ^ Bowman ES, Coons PM (2000). "The differential diagnosis of epilepsy, pseudoseizures, dissociative identity disorder, and dissociative disorder not otherwise specified". Bulletin of the Menninger Clinic. 64 (2): 164–80. PMID 10842446.
  24. ^ Benbadis SR, LaFrance Jr WC (2010). "Chapter 4. Clinical Features and the Role of Video-EEG Monitoring". In Schachter SC, LaFrance Jr WC (eds.). Gates and Rowan's Nonepileptic Seizures (3rd ed.). Cambridge; New York: Cambridge University Press. pp. 38–50.
  25. ^ a b Reuber M, Elger CE (June 2003). "Psychogenic nonepileptic seizures: review and update". Epilepsy & Behavior. 4 (3): 205–16. doi:10.1016/S1525-5050(03)00104-5. PMID 12791321. S2CID 25347605.
  26. ^ LaFrance WC, Reuber M, Goldstein LH (March 2013). "Management of psychogenic nonepileptic seizures". Epilepsia. 54 Suppl 1: 53–67. doi:10.1111/epi.12106. PMID 23458467.
  27. ^ Goldstein, Laura H.; Robinson, Emily J.; Chalder, Trudie; Reuber, Markus; Medford, Nick; Stone, Jon; Carson, Alan; Moore, Michele; Landau, Sabine (March 2022). "Six-month outcomes of the CODES randomised controlled trial of cognitive behavioural therapy for dissociative seizures: A secondary analysis". Seizure. 96: 128–136. doi:10.1016/j.seizure.2022.01.016. ISSN 1532-2688. PMC 8970049. PMID 35228117.
  28. ^ a b Fobian AD, Long DM, Szaflarski JP (August 2020). "Retraining and control therapy for pediatric psychogenic non-epileptic seizures". Annals of Clinical and Translational Neurology. 7 (8): 1410–1419. doi:10.1002/acn3.51138. PMC 7448150. PMID 32748572.
  29. ^ Asadi-Pooya, Ali A.; Brigo, Francesco; Tolchin, Benjamin; Valente, Kette D. (2021). "Functional seizures are not less important than epilepsy". Epilepsy & Behavior Reports. 16: 100495. doi:10.1016/j.ebr.2021.100495. ISSN 2589-9864. PMC 8585631. PMID 34805820.
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