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Adductomics refers to is the study of the totality of adducts arising from either nucleic acids, such as DNA, and RNA, or proteins, the context of the totality of the adducts e.g., all the different DNA adducts that are present in the genome of a particular sample. DNA adducts arise from compounds that bind to DNA, that covalently modify the DNA, resulting in damage. This damage can result in mutations. These mutations can result in a variety of adverse health effects, including cancer and birth defects in multicellular organisms. The science of adductomics seeks to identify all DNA adducts and the target sequence of each adduct.

The term "adductome" first appeared in a journal article in 2005.^[1] Although originally the term related to adducts of DNA, the adductomic approach has now been adopted by protein chemists in their attempts to identify protein adducts. More recently, this has been extended by Kanaly's group to include RNA adducts^[2].

References

^ MATSUDA TOMONARI, ROBERT A. KANALY, HANAOKA TOMOYUKI, SUGIMURA HARUHIKO, TODA HIROKAZU, MATSUI SABURO. 2005. "DNA adductome strategy for detection of multiple DNA adducts." Nippon Kankyo Hen'igen Gakkai Taikai Puroguramu, Yoshishu. 34:77
^ Takeshita, Toshihide; Kanaly, Robert A. (2019). "In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line". Frontiers in Chemistry. 7. doi:10.3389/fchem.2019.00491/full. ISSN 2296-2646.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[1] MATSUDA TOMONARI, ROBERT A. KANALY, HANAOKA TOMOYUKI, SUGIMURA HARUHIKO, TODA HIROKAZU, MATSUI SABURO. 2005. "DNA adductome strategy for detection of multiple DNA adducts." Nippon Kankyo Hen'igen Gakkai Taikai Puroguramu, Yoshishu. 34:77

[2] Takeshita, Toshihide; Kanaly, Robert A. (2019). "In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line". Frontiers in Chemistry. 7. doi:10.3389/fchem.2019.00491/full. ISSN 2296-2646.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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 {{Short description|Study of DNA adducts}}
-'''Adductomics''' is the study of [[DNA adducts]] in the context of an entire [[genome]].  DNA adducts are [[Chemical compound|compounds]] that bind to [[DNA]], causing damage and [[mutations]].  These mutations can result in [[cancer]] and [[birth defects]] in [[multicellular organisms]].  The science of adductomics seeks to identify all DNA adducts and the target sequence of each adduct.
+'''Adductomics''' refers to is the study of the totality of [[Adduct|adducts]] arising from either nucleic acids, such as [[DNA]], and [[RNA]], or [[Protein|proteins]], the context of the totality of the adducts e.g., all the different DNA adducts that are present in the genome of a particular sample.  [[DNA adducts]] arise from [[Chemical compound|compounds]] that bind to [[DNA]], that covalently modify the DNA, resulting in damage. This damage can result in [[mutations]].  These mutations can result in a variety of adverse health effects, including [[cancer]] and [[birth defects]] in [[multicellular organisms]].  The science of adductomics seeks to identify all DNA adducts and the target sequence of each adduct.
-The term "adductome" first appeared in a journal article in 2005.<ref>MATSUDA TOMONARI, ROBERT A. KANALY, HANAOKA TOMOYUKI, SUGIMURA HARUHIKO, TODA HIROKAZU, MATSUI SABURO.  2005.  "DNA adductome strategy for detection of multiple DNA adducts." Nippon Kankyo Hen'igen Gakkai Taikai Puroguramu, Yoshishu.  34:77</ref>  Although originally the term related to adducts of DNA, the adductomic approach has now been adopted by [[protein]] chemists in their attempts to identify [[protein adducts]].
+The term "adductome" first appeared in a journal article in 2005.<ref>MATSUDA TOMONARI, ROBERT A. KANALY, HANAOKA TOMOYUKI, SUGIMURA HARUHIKO, TODA HIROKAZU, MATSUI SABURO.  2005.  "DNA adductome strategy for detection of multiple DNA adducts." Nippon Kankyo Hen'igen Gakkai Taikai Puroguramu, Yoshishu.  34:77</ref>  Although originally the term related to adducts of DNA, the adductomic approach has now been adopted by [[protein]] chemists in their attempts to identify [[protein adducts]]. More recently, this has been extended by Kanaly's group to include RNA adducts<ref>{{Cite journal |last=Takeshita |first=Toshihide |last2=Kanaly |first2=Robert A. |date=2019 |title=In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line |url=https://www.frontiersin.org/articles/10.3389/fchem.2019.00491 |journal=Frontiers in Chemistry |volume=7 |doi=10.3389/fchem.2019.00491/full |issn=2296-2646}}</ref>.
 ==References==