Talk:Morphine

Fatal dose

" One poor quality study on morphine overdoses among soldiers reported that the fatal dose was 0.78 mcg/ml in males (~71 mg for an average 90 kg adult man) and 0.98mcg/ml in females (~74 mg for an average 75 kg female). It was not specified whether the dose was oral, parenteral or IV "

Surely it does not matter whether the dose was oral or IV if this is referring to final blood concentration? If oral bioavailability is about 1/3 then the fatal dose would be about 225mg orally would it not? (though this seems rather low) Of course one would then also have to consider the timescale over which the dose was taken etc — Preceding unsigned comment added by 82.26.113.110 (talk) 18:43, 6 March 2021 (UTC)

Need for expert attention

@Doc James: I would recommend you find a good chemist to look at the chemistry section of the Morphine article. I moved the chemical synthesis out, because that description is okay (better, were it based on reviews, but at least it is sourced). But the real issue is that the chemistry section—which reads as naive—is, moreover, completely unsourced. (I removed the only two prior citations, one to a high school web page, and the other to a college class handout, as inapproproate for such an important substance with such a rich literature.) Were I a logging editor, I would have taken the whole thing out, as suspected plagiarism, and on the basis of its misstatements (so rampant it is with vagaries and inaccuracies). Instead, I "hid" 2-3 glaring examples (not even the most glaring), and indicated the problem with a section tag. [ a former prof.] 2601:246:C700:19D:E50A:9B38:6680:3C78 (talk) 20:59, 7 February 2020 (UTC)

Feel free to keep working on it :-) Not really my area of interest. If you see stuff that is unreferenced and incorrect feel free to remove it. Doc James (talk · contribs · email) 00:30, 8 February 2020 (UTC)

Minor nomenclature issue

The stereochemical descriptions of the intermediate enantiomers in the biosynthesis sections are presented in two different styles. I leave it to the experts to decide between the two styles (with or without parens/italics), and propagate just one for the sake of student readers. Also, the PD table mentions the dextro- and levo- forms alongside "Morphine", which here, alongside the two, implies what... activity data on the racemate? (I am not sure I believe this, but it is possible that such was formulated.) I would clarify this, and recommend 2-3 other sourced sentences, placed appropriately throughout, including in the lead, making clear the stereochemical form of what most know as morphine, the poppy- and human-derived molecule. Merci. 2601:246:C700:19D:E50A:9B38:6680:3C78 (talk) 21:07, 7 February 2020 (UTC)

Metadon

Vem har någon erfarenhet av Levopidon? Morfius1976 (talk) 10:55, 14 February 2021 (UTC)

en:Levomethadone is a synthetic opioid analgesic and antitussive which is marketed in Europe and is used for pain management and in opioid maintenance therapy.

RicHard-59 (talk) 08:56, 29 November 2022 (UTC)

More addictive than...

So the, history part has a sentence "Later it was found that morphine was more addictive than either alcohol or opium".

But not sure if this is true, or what it even means. Isn't the main ingredient of opium morphine, which should make it exactly as addictive, if not more (if the other compounds have additive effects)? Also, alcohols are extremely addictive, so without a references I find it hard to believe that morphine can be more addictive, although maybe I am wrong. Is there any reference for this? 84.248.117.35 (talk) 16:35, 24 March 2022 (UTC)

Dose

Wow. This is a really bad article. Administration - check it out: IV isn't one of the routes!!! WHAT?? Check it out - it is claimed that it last 3-7 hrs but I had no problem finding a source that said it was effective for 24 hrs (epidurally). I don't think it's true that there is a meaningful number range for its effects. First because of the wide variety of routes of administration, and secondly because different people can have different responses (both due to genetics, habituation, health, and other factors). 98.17.44.45 (talk) 18:40, 15 October 2023 (UTC)

In the sidebar, IV is specifically mentioned in Routes of Administration.

I am not surprised that duration of action from epidural administration greatly differs from oral/parenteral (systemic) administration. I think it would be reasonable to list the epidural duration of action (sourced) in addition to the 3-7 hour claim for systemic administration. The 3-7 hours claim from drugs.com is:

Following oral, rectal, sub-Q, IM, or IV administration, analgesia may be maintained up to 7 hours.

The second source on the duration of action, Rockwood and Wilkins' fractures in children, does say duration of action is typically 3-4 hours. As such I think it's reasonable to say 3-7 hours. Of note: the archived link for the book source is dead over at archive.org, but the live version is still available.

The "different people can have different responses" is an issue with all drugs, and is part of why a range is given for duration of action; the Pharmacokinetics section already mentions these factors specifically.

Kimen8 (talk) 19:54, 15 October 2023 (UTC)