Tinospora cordifolia: Difference between revisions
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==Traditional medicine== |
==Traditional medicine== |
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Although used in [[Ayurveda]] over centuries in the belief that ''Tinospora'' has medicinal properties,<ref>{{cite journal | doi=10.2174/1389201021666200430114547 | title=''Tinospora cordifolia'' (giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies | year=2020 | last1=Kumar | first1=Pradeep | last2=Kamle | first2=Madhu | last3=Mahato | first3=Dipendra K. | last4=Bora | first4=Himashree | last5=Sharma | first5=Bharti | last6=Rasane | first6=Prasad | last7=Bajpai | first7=Vivek K. | journal=Current Pharmaceutical Biotechnology | volume=21 | issue=12 | pages=1165–1175 | pmid=32351180 | s2cid=217593876 }}</ref> there is no evidence from reviews of [[clinical research]] to indicate that it has any effect.<ref name=drugs/> The hepatoprotective properties of T. cordifolia arise from its ability to inhibit lipid peroxidation, address oxidative stress, and influence various other factors.<ref>{{Cite journal |last= |
Although used in [[Ayurveda]] over centuries in the belief that ''Tinospora'' has medicinal properties,<ref>{{cite journal | doi=10.2174/1389201021666200430114547 | title=''Tinospora cordifolia'' (giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies | year=2020 | last1=Kumar | first1=Pradeep | last2=Kamle | first2=Madhu | last3=Mahato | first3=Dipendra K. | last4=Bora | first4=Himashree | last5=Sharma | first5=Bharti | last6=Rasane | first6=Prasad | last7=Bajpai | first7=Vivek K. | journal=Current Pharmaceutical Biotechnology | volume=21 | issue=12 | pages=1165–1175 | pmid=32351180 | s2cid=217593876 }}</ref> there is no evidence from reviews of [[clinical research]] to indicate that it has any effect.<ref name=drugs/> The hepatoprotective properties of T. cordifolia arise from its ability to inhibit lipid peroxidation, address oxidative stress, and influence various other factors.<ref>{{Cite journal |last=Acharya Balakrishna, Ashwani Kumar, Akansha Rohela, Vedpriya Arya, Ajay Kumar Gautam, Hemant Sharma, Priyanka Rai, Amita Kumari, Ryszard Amarowicz |first= |date=27/01/2024 |title=Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review |url=https://doi.org/10.1093/jpp/rgae013 |journal=Journal of Pharmacy and Pharmacology}}</ref> |
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During the 2020-22 COVID-19 outbreak in India, the [[Ministry of AYUSH]] recommended use of ''T. cordifolia'' ("giloy") as a [[traditional medicine|home remedy]] for [[immune system|immune support]],<ref name="wire">{{cite web|author=Banjot Kaur|url=https://science.thewire.in/health/india-silent-outbreak-giloy-induced-livery-injury-ayurveda-ayush/ |title=As COVID Surged, India Had a Silent Outbreak of Giloy-Induced Liver Injury |date=17 February 2022|publisher=Science: The Wire}}</ref> but such a practice appeared to be associated with [[hepatitis]] cases among six people in [[Mumbai]] who used boiled or capsule preparations of the plant.<ref name=wire/><ref name="Nagral">{{cite journal|display-authors=3 | last1=Nagral | first1=Aabha | last2=Adhyaru | first2=Kunal | last3=Rudra | first3=Omkar S. | last4=Gharat | first4=Amit | last5=Bhandare | first5=Sonal | title=Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series | journal=Journal of Clinical and Experimental Hepatology | volume=11 | issue=6 | date=2021-07-02 | issn=0973-6883 | pmid=34230786 | pmc=8252698 | doi=10.1016/j.jceh.2021.06.021 | pages=732–738}}</ref><ref name="DH Ray">{{cite news |last=Ray |first=Kalyan |url=https://www.deccanherald.com/national/ayurvedic-drug-backed-by-ayush-ministry-causes-liver-damage-says-study-1088604.html |title=Ayurvedic drug backed by AYUSH Ministry causes liver damage, says study |date=6 March 2022 |work=Deccan Herald |publisher=The Printers, Mysore}}</ref><ref>{{cite journal|display-authors=3 |last1=Kulkarni |first1=Anand V. |last2=Hanchanale |first2=Pavan |last3=Prakash |first3=Vikash |last4=Kalal |first4=Chetan |last5=Sharma |first5=Mithun |last6=Kumar |first6=Karan |last7=Bishnu |first7=Saptarshi |last8=Kulkarni |first8=Aditya V. |last9=Anand |first9=Lovkesh |last10=Patwa |first10=Ajay Kumar |last11=Kumbar |first11=Sandeep |last12=Kainth |first12=Sumeet |last13=Philips |first13=Cyriac Abby |title=''Tinospora cordifolia'' ( giloy)–induced liver injury during the COVID‐19 pandemic — Multicenter nationwide study from India |journal=Hepatology Communications |date=6 February 2022 |volume=6 |issue=6 |pages=1289–1300 |doi=10.1002/hep4.1904|pmid=35037744 |pmc=9134809 }}</ref> |
During the 2020-22 COVID-19 outbreak in India, the [[Ministry of AYUSH]] recommended use of ''T. cordifolia'' ("giloy") as a [[traditional medicine|home remedy]] for [[immune system|immune support]],<ref name="wire">{{cite web|author=Banjot Kaur|url=https://science.thewire.in/health/india-silent-outbreak-giloy-induced-livery-injury-ayurveda-ayush/ |title=As COVID Surged, India Had a Silent Outbreak of Giloy-Induced Liver Injury |date=17 February 2022|publisher=Science: The Wire}}</ref> but such a practice appeared to be associated with [[hepatitis]] cases among six people in [[Mumbai]] who used boiled or capsule preparations of the plant.<ref name=wire/><ref name="Nagral">{{cite journal|display-authors=3 | last1=Nagral | first1=Aabha | last2=Adhyaru | first2=Kunal | last3=Rudra | first3=Omkar S. | last4=Gharat | first4=Amit | last5=Bhandare | first5=Sonal | title=Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series | journal=Journal of Clinical and Experimental Hepatology | volume=11 | issue=6 | date=2021-07-02 | issn=0973-6883 | pmid=34230786 | pmc=8252698 | doi=10.1016/j.jceh.2021.06.021 | pages=732–738}}</ref><ref name="DH Ray">{{cite news |last=Ray |first=Kalyan |url=https://www.deccanherald.com/national/ayurvedic-drug-backed-by-ayush-ministry-causes-liver-damage-says-study-1088604.html |title=Ayurvedic drug backed by AYUSH Ministry causes liver damage, says study |date=6 March 2022 |work=Deccan Herald |publisher=The Printers, Mysore}}</ref><ref>{{cite journal|display-authors=3 |last1=Kulkarni |first1=Anand V. |last2=Hanchanale |first2=Pavan |last3=Prakash |first3=Vikash |last4=Kalal |first4=Chetan |last5=Sharma |first5=Mithun |last6=Kumar |first6=Karan |last7=Bishnu |first7=Saptarshi |last8=Kulkarni |first8=Aditya V. |last9=Anand |first9=Lovkesh |last10=Patwa |first10=Ajay Kumar |last11=Kumbar |first11=Sandeep |last12=Kainth |first12=Sumeet |last13=Philips |first13=Cyriac Abby |title=''Tinospora cordifolia'' ( giloy)–induced liver injury during the COVID‐19 pandemic — Multicenter nationwide study from India |journal=Hepatology Communications |date=6 February 2022 |volume=6 |issue=6 |pages=1289–1300 |doi=10.1002/hep4.1904|pmid=35037744 |pmc=9134809 }}</ref> |
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Revision as of 10:55, 2 February 2024
| Tinospora cordifolia | |
|---|---|
| |
Scientific classification 
| |
| Kingdom: | Plantae |
| Clade: | Tracheophytes |
| Clade: | Angiosperms |
| Clade: | Eudicots |
| Order: | Ranunculales |
| Family: | Menispermaceae |
| Genus: | Tinospora |
| Species: | T. cordifolia
|
| Binomial name | |
| Tinospora cordifolia (Thunb.) Miers
| |
Tinospora cordifolia (common names heart-leaved moonseed, guduchi or giloy, among others) is a herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent.[1] It has been used in Ayurveda to treat various disorders.[1]
Botanical description
It is a large, deciduous, extensively-spreading, climbing vine with several elongated twining branches. Leaves are simple, alternate, and exstipulate with long petioles up to 15 cm (6 in) long which are roundish and pulvinate, both at the base and apex with the basal one longer and twisted partially and half way around. It gets its name heart-leaved moonseed by its heart-shaped leaves and its reddish fruit. Lamina are broadly ovate or ovate cordate, 10–20 cm (4–8 in) long or 8–15 cm (3–6 in) broad, seven nerved and deeply cordate at base, membranous, pubescent above, whitish tomentose with a prominent reticulum beneath.
Flowers are unisexual, small on separate plants and appearing when the plant is leafless, greenish-yellow on axillary and terminal racemes. Male flowers are clustered, but female flowers are usually solitary. It has six sepals in two series of three each. The outer ones are smaller than the inner. It has six petals which are smaller than sepals, obovate, and membranous. Fruits aggregate in clusters of one to three. They are ovoid smooth drupelets on thick stalks with sub terminal style scars, scarlet or orange colored.[2]
Ecology
Endophytic fungi colonize the living, internal tissues of their host without causing any harmful effects. A recent study has shown that 29 endophytes belonging to different taxa were present in the samples collected from Tinospora cordifolia.[3]
Extracts of the endophytic fungus Nigrospora sphaerica obtained from T. cordifolia were found to have insecticidal properties against the Oriental leafworm moth (Spodoptera litura), a polyphagous pest.[4]
Phytochemicals
Tinospora cordifolia contains diverse phytochemicals, including alkaloids, phytosterols, glycosides, tinosporide, and various other phytochemicals.[1][5]
Traditional medicine
Although used in Ayurveda over centuries in the belief that Tinospora has medicinal properties,[6] there is no evidence from reviews of clinical research to indicate that it has any effect.[1] The hepatoprotective properties of T. cordifolia arise from its ability to inhibit lipid peroxidation, address oxidative stress, and influence various other factors.[7]
During the 2020-22 COVID-19 outbreak in India, the Ministry of AYUSH recommended use of T. cordifolia ("giloy") as a home remedy for immune support,[8] but such a practice appeared to be associated with hepatitis cases among six people in Mumbai who used boiled or capsule preparations of the plant.[8][9][10][11]
References
- ^ a b c d "Tinospora". Drugs.com. 18 November 2023. Retrieved 13 February 2023.
- ^ Sinha, Kirti; Mishra, N P; Singh, J; Khanuja, S P S (July 2004). "Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: A Review". Indian Journal of Traditional Knowledge. 3 (3): 257–70.
- ^ Mishra, Ashish; Gond, Surendra K.; Kumar, Anuj; Sharma, Vijay K.; Verma, Satish K.; Kharwar, Ravindra N.; Sieber, Thomas N. (2012). "Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location". Microbial Ecology. 64 (2): 388–98. doi:10.1007/s00248-012-0029-7. PMID 22430503. S2CID 10738815.
- ^ Thakur, Abhinay; Kaur, Sanehdeep; Kaur, Amarjeet; Singh, Varinder (2012). "Detrimental effects of endophytic fungus Nigrospora sp. on survival and development of Spodoptera litura". Biocontrol Science and Technology. 22 (2): 151–61. doi:10.1080/09583157.2011.646952. S2CID 85075708.
- ^ Swaminathan, K.; Sinha, U. C.; Bhatt, R. K.; Sabata, B. K.; Tavale, S. S. (1989). "Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers". Acta Crystallographica Section C. 45 ( Pt 1): 134–136. doi:10.1107/s0108270188009953. PMID 2610955.
- ^ Kumar, Pradeep; Kamle, Madhu; Mahato, Dipendra K.; Bora, Himashree; Sharma, Bharti; Rasane, Prasad; Bajpai, Vivek K. (2020). "Tinospora cordifolia (giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies". Current Pharmaceutical Biotechnology. 21 (12): 1165–1175. doi:10.2174/1389201021666200430114547. PMID 32351180. S2CID 217593876.
- ^ Acharya Balakrishna, Ashwani Kumar, Akansha Rohela, Vedpriya Arya, Ajay Kumar Gautam, Hemant Sharma, Priyanka Rai, Amita Kumari, Ryszard Amarowicz (27/01/2024). "Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review". Journal of Pharmacy and Pharmacology.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: multiple names: authors list (link) - ^ a b Banjot Kaur (17 February 2022). "As COVID Surged, India Had a Silent Outbreak of Giloy-Induced Liver Injury". Science: The Wire.
- ^ Nagral, Aabha; Adhyaru, Kunal; Rudra, Omkar S.; et al. (2021-07-02). "Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series". Journal of Clinical and Experimental Hepatology. 11 (6): 732–738. doi:10.1016/j.jceh.2021.06.021. ISSN 0973-6883. PMC 8252698. PMID 34230786.
- ^ Ray, Kalyan (6 March 2022). "Ayurvedic drug backed by AYUSH Ministry causes liver damage, says study". Deccan Herald. The Printers, Mysore.
- ^ Kulkarni, Anand V.; Hanchanale, Pavan; Prakash, Vikash; et al. (6 February 2022). "Tinospora cordifolia ( giloy)–induced liver injury during the COVID‐19 pandemic — Multicenter nationwide study from India". Hepatology Communications. 6 (6): 1289–1300. doi:10.1002/hep4.1904. PMC 9134809. PMID 35037744.