Osteoarthritis: Difference between revisions

Osteoarthritis
Osteoarthritis
Other names	Arthrosis, osteoarthrosis, degenerative arthritis, degenerative joint disease
	The formation of hard knobs at the middle finger joints (known as Bouchard's nodes) and at the farthest joints of the fingers (known as Heberden's nodes) is a common feature of osteoarthritis in the hands.
Pronunciation	/ˌɒstioʊɑːrˈθraɪtɪs/ ;
Specialty	Rheumatology, orthopedics
Symptoms	Joint pain, stiffness, joint swelling, decreased range of motion
Usual onset	Over years
Causes	Connective tissue disease, previous joint injury, abnormal joint or limb development, inherited factors
Risk factors	Overweight, legs of different lengths, job with high levels of joint stress
Diagnostic method	Based on symptoms, supported by other testing
Treatment	Exercise, efforts to decrease joint stress, support groups, pain medications, joint replacement
Frequency	237 million / 3.3% (2015)

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Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone.^[5]^[6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone.^[7] The most common symptoms are joint pain and stiffness.^[1] Usually the symptoms progress slowly over years.^[1] Other symptoms may include joint swelling, decreased range of motion, and, when the back is affected, weakness or numbness of the arms and legs.^[1] The most commonly involved joints are the two near the ends of the fingers and the joint at the base of the thumbs, the knee and hip joints, and the joints of the neck and lower back.^[1] The symptoms can interfere with work and normal daily activities.^[1] Unlike some other types of arthritis, only the joints, not internal organs, are affected.^[1]

Causes include previous joint injury, abnormal joint or limb development, and inherited factors.^[1]^[2] Risk is greater in those who are overweight, have legs of different lengths, or have jobs that result in high levels of joint stress.^[1]^[2]^[8] Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes.^[9] It develops as cartilage is lost and the underlying bone becomes affected.^[1] As pain may make it difficult to exercise, muscle loss may occur.^[2]^[10] Diagnosis is typically based on signs and symptoms, with medical imaging and other tests used to support or rule out other problems.^[1] In contrast to rheumatoid arthritis, in osteoarthritis the joints do not become hot or red.^[1]

Treatment includes exercise, decreasing joint stress such as by rest or use of a cane, support groups, and pain medications.^[1]^[3] Weight loss may help in those who are overweight.^[1] Pain medications may include paracetamol (acetaminophen) as well as NSAIDs such as naproxen or ibuprofen.^[1] Long-term opioid use is not recommended due to lack of information on benefits as well as risks of addiction and other side effects.^[1]^[3] Joint replacement surgery may be an option if there is ongoing disability despite other treatments.^[2] An artificial joint typically lasts 10 to 15 years.^[11]

Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population, as of 2015.^[4]^[12] It becomes more common as people age.^[1] Among those over 60 years old, about 10% of males and 18% of females are affected.^[2] Osteoarthritis is the cause of about 2% of years lived with disability.^[12]

Signs and symptoms

Outline of female body indicating most affected areas — Osteoarthritis most often occurs in the hands (at the ends of the fingers and thumbs), neck, lower back, knees, and hips.

The main symptom is pain, causing loss of ability and often stiffness. The pain is typically made worse by prolonged activity and relieved by rest. Stiffness is most common in the morning, and typically lasts less than thirty minutes after beginning daily activities, but may return after periods of inactivity. Osteoarthritis can cause a crackling noise (called "crepitus") when the affected joint is moved, especially shoulder and knee joint. A person may also complain of joint locking and joint instability. These symptoms would affect their daily activities due to pain and stiffness.^[13] Some people report increased pain associated with cold temperature, high humidity, or a drop in barometric pressure, but studies have had mixed results.^[14]

Osteoarthritis commonly affects the hands, feet, spine, and the large weight-bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As osteoarthritis progresses, movement patterns (such as gait), are typically affected.^[1] Osteoarthritis is the most common cause of a joint effusion of the knee.^[15]

In smaller joints, such as at the fingers, hard bony enlargements, called Heberden's nodes (on the distal interphalangeal joints) or Bouchard's nodes (on the proximal interphalangeal joints), may form, and though they are not necessarily painful, they do limit the movement of the fingers significantly. Osteoarthritis of the toes may be a factor causing formation of bunions,^[16] rendering them red or swollen.

Causes

Damage from mechanical stress with insufficient self repair by joints is believed to be the primary cause of osteoarthritis.^[17] Sources of this stress may include misalignments of bones caused by congenital or pathogenic causes; mechanical injury; excess body weight; loss of strength in the muscles supporting a joint; and impairment of peripheral nerves, leading to sudden or uncoordinated movements.^[17] However exercise, including running in the absence of injury, has not been found to increase the risk of knee osteoarthritis.^[18]^[19] Nor has cracking one's knuckles been found to play a role.^[20] The risk of osteoarthritis increases with aging.

Primary

The development of osteoarthritis is correlated with a history of previous joint injury and with obesity, especially with respect to knees.^[21] Changes in sex hormone levels may play a role in the development of osteoarthritis, as it is more prevalent among post-menopausal women than among men of the same age.^[1]^[22] Conflicting evidence exists for the differences in hip and knee osteoarthritis in African Americans and Caucasians.^[23]

Occupational

Increased risk of developing knee and hip osteoarthritis was found among those who work with manual handling (e.g. lifting), have physically demanding work, walk at work, and have climbing tasks at work (e.g. climb stairs or ladders).^[8] With hip osteoarthritis, in particular, increased risk of development over time was found among those who work in bent or twisted positions.^[8] For knee osteoarthritis, in particular, increased risk was found among those who work in a kneeling or squatting position, experience heavy lifting in combination with a kneeling or squatting posture, and work standing up.^[8] Women and men have similar occupational risks for the development of osteoarthritis.^[8]

Secondary

Lateral

Frontal

Secondary osteoarthritis of the ankle (due to an old bone fracture) in an 82-year-old woman

This type of osteoarthritis is caused by other factors but the resulting pathology is the same as for primary osteoarthritis:

Alkaptonuria^[24]
Congenital disorders of joints^[25]^[26]
Diabetes doubles the risk of having a joint replacement due to osteoarthritis and people with diabetes have joint replacements at a younger age than those without diabetes.^[27]
Ehlers-Danlos syndrome^[28]
Hemochromatosis and Wilson's disease^[29]
Inflammatory diseases (such as Perthes' disease), (Lyme disease), and all chronic forms of arthritis (e.g., costochondritis, gout, and rheumatoid arthritis). In gout, uric acid crystals cause the cartilage to degenerate at a faster pace.
Injury to joints or ligaments (such as the ACL) as a result of an accident or orthopedic operations.
Ligamentous deterioration or instability may be a factor.
Marfan syndrome^[30]
Obesity^[31]
Joint infection^[32]^[33]^[34]

Pathophysiology

Healthy hip joint

Hip joint with osteoarthritis^[35]

While osteoarthritis is a degenerative joint disease that may cause gross cartilage loss and morphological damage to other joint tissues, more subtle biochemical changes occur in the earliest stages of osteoarthritis progression. The water content of healthy cartilage is finely balanced by compressive force driving water out and hydrostatic and osmotic pressure drawing water in.^[36]^[37] Collagen fibres exert the compressive force, whereas the Gibbs–Donnan effect and cartilage proteoglycans create osmotic pressure which tends to draw water in.^[37]

However, during onset of osteoarthritis, the collagen matrix becomes more disorganized and there is a decrease in proteoglycan content within cartilage. The breakdown of collagen fibers results in a net increase in water content.^[38]^[39]^[40]^[41]^[42] This increase occurs because whilst there is an overall loss of proteoglycans (and thus a decreased osmotic pull),^[39]^[43] it is outweighed by a loss of collagen.^[37]^[43]

Other structures within the joint can also be affected.^[44] The ligaments within the joint become thickened and fibrotic, and the menisci can become damaged and wear away.^[45] Menisci can be completely absent by the time a person undergoes a joint replacement. New bone outgrowths, called "spurs" or osteophytes, can form on the margins of the joints, possibly in an attempt to improve the congruence of the articular cartilage surfaces in the absence of the menisci. The subchondral bone volume increases and becomes less mineralized (hypomineralization).^[46] All these changes can cause problems functioning. The pain in an osteoarthritic joint has been related to thickened synovium^[47] and to subchondral bone lesions.^[48]

Diagnosis

Synovial fluid examination^[49]^[50]
Type	WBC (per mm³)	% neutrophils	Viscosity	Appearance
Normal	<200	0	High	Transparent
Osteoarthritis	<5000	<25	High	Clear yellow
Trauma	<10,000	<50	Variable	Bloody
Inflammatory	2,000–50,000	50–80	Low	Cloudy yellow
Septic arthritis	>50,000	>75	Low	Cloudy yellow
Gonorrhea	~10,000	60	Low	Cloudy yellow
Tuberculosis	~20,000	70	Low	Cloudy yellow
Inflammatory: Arthritis, gout, rheumatoid arthritis, rheumatic fever

Diagnosis is made with reasonable certainty based on history and clinical examination.^[51]^[52] X-rays may confirm the diagnosis. The typical changes seen on X-ray include: joint space narrowing, subchondral sclerosis (increased bone formation around the joint), subchondral cyst formation, and osteophytes.^[53] Plain films may not correlate with the findings on physical examination or with the degree of pain.^[54]

In 1990, the American College of Rheumatology, using data from a multi-center study, developed a set of criteria for the diagnosis of hand osteoarthritis based on hard tissue enlargement and swelling of certain joints.^[55] These criteria were found to be 92% sensitive and 98% specific for hand osteoarthritis versus other entities such as rheumatoid arthritis and spondyloarthropathies.^[56]

Severe osteoarthritis and osteopenia of the carpal joint and 1st carpometacarpal joint
MRI of osteoarthritis in the knee, with characteristic narrowing of the joint space
Primary osteoarthritis of the left knee. Note the osteophytes, narrowing of the joint space (arrow), and increased subchondral bone density (arrow).
Damaged cartilage from sows. (a) cartilage erosion (b)cartilage ulceration (c)cartilage repair (d)osteophyte (bone spur) formation.
Histopathology of osteoarthrosis of a knee joint in an elderly female
Histopathology of osteoarthrosis of a knee joint in an elderly female
In a healthy joint, the ends of bones are encased in smooth cartilage. Together, they are protected by a joint capsule lined with a synovial membrane that produces synovial fluid. The capsule and fluid protect the cartilage, muscles, and connective tissues.
With osteoarthritis, the cartilage becomes worn away. Spurs grow out from the edge of the bone, and synovial fluid increases. Altogether, the joint feels stiff and sore.
Osteoarthritis
Bone (left) and clinical (right) changes of the hand in osteoarthritis

Classification

A number of classification systems are used for gradation of osteoarthritis:

WOMAC scale, taking into account pain, stiffness and functional limitation.^[57]
Kellgren-Lawrence grading scale for osteoarthritis of the knee. It uses only projectional radiography features.
Tönnis classification for osteoarthritis of the hip joint, also using only projectional radiography features.^[58]

Both primary generalized nodal osteoarthritis and erosive osteoarthritis (EOA, also called inflammatory osteoarthritis) are sub-sets of primary osteoarthritis. EOA is a much less common, and more aggressive inflammatory form of osteoarthritis which often affects the distal interphalangeal joints of the hand and has characteristic articular erosive changes on X-ray.^[59]

Management

Illustration of example strengthening, aerobic conditioning, and range of motion exercises — Some kinds of exercise recommended in OA

Lifestyle modification (such as weight loss and exercise) and pain medications are the mainstays of treatment. Acetaminophen (also known as paracetamol) is recommended first line, with NSAIDs being used as add-on therapy only if pain relief is not sufficient.^[60]^[61] Medications that alter the course of the disease have not been found as of 2018.^[62] Recommendations include modification of risk factors through targeted interventions including 1) obesity and overweight, 2) physical activity, 3) dietary exposures, 4) comorbidity, 5) biomechanical factors, 6) occupational factors.^[63]

Successful management of the condition is often made more difficult by differing priorities and poor communication between clinicians and people with osteoarthritis. Realistic treatment goals can be achieved by developing a shared understanding of the condition, actively listening to patient concerns, avoiding medical jargon and tailoring treatment plans to the patient's needs.^[64]^[65]

Lifestyle changes

For overweight people, weight loss may help relieve hip arthritis.^[66] Weight loss and exercise provide long-term treatment and are advocated in people with osteoarthritis.^[67] High impact exercise can increase the risk of joint injury, whereas low or moderate impact exercise, such as walking or swimming, is safer for people with osteoarthritis.^[67] A study has suggested that an increase in blood calcium levels had a positive impact on osteoarthritis. An adequate dietary calcium intake and regular weight-bearing exercise can increase calcium levels and is helpful in preventing osteoarthritis in the general population. There is also a weak protective effect factor of LDL (low-density lipoprotein) cholesterol. However, this is not recommended since an increase in LDL has an increased chance of cardiovascular comorbidities. ^[68]

As an adjunct to these lifestyle changes, use of analgesia, intra-articular cortisone injection and consideration of hyaluronic acids and platelet-rich plasma are recommended for pain relief in people with knee osteoarthritis.^[69] Education is helpful in self-management of arthritis, and can provide coping methods leading to about 20% more pain relief when compared to NSAIDs alone.^[66]

Physical measures

Moderate exercise may be beneficial with respect to pain and function in those with osteoarthritis of the knee and hip.^[70]^[71]^[72] These exercises should occur at least three times per week.^[73] While some evidence supports certain physical therapies, evidence for a combined program is limited.^[74] Providing clear advice, making exercises enjoyable, and reassuring people about the importance of doing exercises may lead to greater benefit and more participation.^[72] Limited evidence suggests that supervised exercise therapy may improve exercise adherence.^[75] There is not enough evidence to determine the effectiveness of massage therapy.^[76] The evidence for manual therapy is inconclusive.^[77] A 2015 review indicated that aquatic therapy is safe, effective, and can be an adjunct therapy for knee osteoarthritis.^[78]

Functional, gait, and balance training have been recommended to address impairments of position sense, balance, and strength in individuals with lower extremity arthritis, as these can contribute to a higher rate of falls in older individuals.^[79]^[80] For people with hand osteoarthritis, exercises may provide small benefits for improving hand function, reducing pain, and relieving finger joint stiffness.^[81]

Lateral wedge insoles and neutral insoles do not appear to be useful in osteoarthritis of the knee.^[82]^[83]^[84] Knee braces may help^[85] but their usefulness has also been disputed.^[84] For pain management heat can be used to relieve stiffness, and cold can relieve muscle spasms and pain.^[86] Among people with hip and knee osteoarthritis, exercise in water may reduce pain and disability, and increase quality of life in the short term.^[87] Also therapeutic exercise programs such as aerobics and walking reduce pain and improve physical functioning for up to 6 months after the end of the program for people with knee osteoarthritis.^[88] In a study conducted over a period of 2 years on a group of individuals, a research team found that for every additional 1,000 steps per day, there was a 16% reduction in functional limitations in cases of knee osteoarthritis.^[89] Hydrotherapy might also be an advantage on the management of pain, disability and quality of life reported by people with osteoarthritis.^[90]

Thermotherapy

A 2003 Cochrane review of 7 studies between 1969 and 1999 found ice massage to be of significant benefit in improving range of motion and function, though not necessarily relief of pain.^[91] Cold packs could decrease swelling, but hot packs had no effect on swelling.^[91] Heat therapy could increase circulation, thereby reducing pain and stiffness, but with risk of inflammation and edema.^[91]

Medication

Treatment recommendations by risk factors
GI risk	CVD risk	Option
Low	Low	NSAID, or paracetamol^[92]
Moderate	Low	Paracetamol, or low dose NSAID with antacid^[92]
Low	Moderate	Paracetamol, or low dose aspirin with an antacid^[92]
Moderate	Moderate	Low dose paracetamol, aspirin, and antacid. Monitoring for abdominal pain or black stool.^[92]

By mouth

The pain medication paracetamol (acetaminophen) is the first line treatment for osteoarthritis.^[60]^[93] Pain relief does not differ according to dosage.^[61] However, a 2015 review found acetaminophen to have only a small short-term benefit with some laboratory concerns of liver inflammation.^[94] For mild to moderate symptoms effectiveness of acetaminophen is similar to non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen, though for more severe symptoms NSAIDs may be more effective.^[60] NSAIDs are associated with greater side effects such as gastrointestinal bleeding.^[60]

Another class of NSAIDs, COX-2 selective inhibitors (such as celecoxib) are equally effective when compared to nonselective NSAIDs, and have lower rates of adverse gastrointestinal effects, but higher rates of cardiovascular disease such as myocardial infarction.^[95] They are also more expensive than non-specific NSAIDs.^[96] Benefits and risks vary in individuals and need consideration when making treatment decisions,^[97] and further unbiased research comparing NSAIDS and COX-2 selective inhibitors is needed.^[98] NSAIDS applied topically are effective for a small number of people.^[99] The COX-2 selective inhibitor rofecoxib was removed from the market in 2004, as cardiovascular events were associated with long term use.^[100]

Failure to achieve desired pain relief in osteoarthritis after two weeks should trigger reassessment of dosage and pain medication.^[101] Opioids by mouth, including both weak opioids such as tramadol and stronger opioids, are also often prescribed. Their appropriateness is uncertain, and opioids are often recommended only when first line therapies have failed or are contraindicated.^[3]^[102] This is due to their small benefit and relatively large risk of side effects.^[103]^[104] The use of tramadol likely does not improve pain or physical function and likely increases the incidence of adverse side effects.^[104] Oral steroids are not recommended in the treatment of osteoarthritis.^[93]

Use of the antibiotic doxycycline orally for treating osteoarthritis is not associated with clinical improvements in function or joint pain.^[105] Any small benefit related to the potential for doxycycline therapy to address the narrowing of the joint space is not clear, and any benefit is outweighed by the potential harm from side effects.^[105]

A 2018 meta-analysis found that oral collagen supplementation for the treatment of osteoarthritis reduces stiffness but does not improve pain and functional limitation.^[106]

Topical

There are several NSAIDs available for topical use, including diclofenac. A Cochrane review from 2016 concluded that reasonably reliable evidence is available only for use of topical diclofenac and ketoprofen in people aged over 40 years with painful knee arthritis.^[99] Transdermal opioid pain medications are not typically recommended in the treatment of osteoarthritis.^[103] The use of topical capsaicin to treat osteoarthritis is controversial, as some reviews found benefit^[107]^[108] while others did not.^[109]

Joint injections

Local drug delivery by intra-articular injection may be more effective and safer in terms of increased bioavailability, less systemic exposure and reduced adverse events.^[111] Several intra-articular medications for symptomatic treatment are available on the market as follows.^[112]

Steroids

Joint injection of glucocorticoids (such as hydrocortisone) leads to short-term pain relief that may last between a few weeks and a few months.^[113] A 2015 Cochrane review found that intra-articular corticosteroid injections of the knee did not benefit quality of life and had no effect on knee joint space; clinical effects one to six weeks after injection could not be determined clearly due to poor study quality.^[114] Another 2015 study reported negative effects of intra-articular corticosteroid injections at higher doses,^[115] and a 2017 trial showed reduction in cartilage thickness with intra-articular triamcinolone every 12 weeks for 2 years compared to placebo.^[116] A 2018 study found that intra-articular triamcinolone is associated with an increase in intraocular pressure.^[117]

Hyaluronic acid

Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis,^[118]^[119] but did increase risk of further pain.^[118] In ankle osteoarthritis, evidence is unclear.^[120]

Radiosynoviorthesis

Injection of beta particle-emitting radioisotopes (called radiosynoviorthesis) is used for the local treatment of inflammatory joint conditions.^[121]

Platelet-rich plasma

The effectiveness of injections of platelet-rich plasma (PRP) is unclear; there are suggestions that such injections improve function but not pain, and are associated with increased risk.^[vague]^[122]^[123] A 2014 Cochrane review of studies involving PRP found the evidence to be insufficient.^[124]

Surgery

Bone fusion

Arthrodesis (fusion) of the bones may be an option in some types of osteoarthritis. An example is ankle osteoarthritis, in which ankle fusion is considered to be the gold standard treatment in end-stage cases.^[125]

Joint replacement

If the impact of symptoms of osteoarthritis on quality of life is significant and more conservative management is ineffective, joint replacement surgery or resurfacing may be recommended. Evidence supports joint replacement for both knees and hips as it is both clinically effective^[126]^[127] and cost-effective.^[128]^[129] People who underwent total knee replacement had improved SF-12 quality of life scores, were feeling better compared to those who did not have surgery, and may have short- and long-term benefits for quality of life in terms of pain and function.^[130]^[131] The beneficial effects of these surgeries may be time-limited due to various environmental factors, comorbidities, and pain in other regions of the body.^[132]

For people who have shoulder osteoarthritis and do not respond to medications, surgical options include a shoulder hemiarthroplasty (replacing a part of the joint), and total shoulder arthroplasty (replacing the joint).^[133]

Biological joint replacement involves replacing the diseased tissues with new ones. This can either be from the person (autograft) or from a donor (allograft).^[134] People undergoing a joint transplant (osteochondral allograft) do not need to take immunosuppressants as bone and cartilage tissues have limited immune responses.^[135] Autologous articular cartilage transfer from a non-weight-bearing area to the damaged area, called osteochondral autograft transfer system, is one possible procedure that is being studied.^[136] When the missing cartilage is a focal defect, autologous chondrocyte implantation is also an option.^[137]

Shoulder replacement

For those with osteoarthritis in the shoulder, a complete shoulder replacement is sometimes suggested to improve pain and function.^[138] Demand for this treatment is expected to increase by 750% by the year 2030.^[138] There are different options for shoulder replacement surgeries, however, there is a lack of evidence in the form of high-quality randomized controlled trials, to determine which type of shoulder replacement surgery is most effective in different situations, what are the risks involved with different approaches, or how the procedure compares to other treatment options.^[138]^[139] There is some low-quality evidence that indicates that when comparing total shoulder arthroplasty over hemiarthroplasty, no large clinical benefit was detected in the short term.^[139] It is not clear if the risk of harm differs between total shoulder arthroplasty or a hemiarthroplasty approach.^[139]

Other surgical options

Osteotomy may be useful in people with knee osteoarthritis, but has not been well studied and it is unclear whether it is more effective than non-surgical treatments or other types of surgery.^[140]^[141] Arthroscopic surgery is largely not recommended, as it does not improve outcomes in knee osteoarthritis,^[142]^[143] and may result in harm.^[144] It is unclear whether surgery is beneficial in people with mild to moderate knee osteoarthritis.^[141]

Unverified treatments

Glucosamine and chondroitin

The effectiveness of glucosamine is controversial.^[145] Reviews have found it to be equal to^[146]^[147] or slightly better than placebo.^[148]^[149] A difference may exist between glucosamine sulfate and glucosamine hydrochloride, with glucosamine sulfate showing a benefit and glucosamine hydrochloride not.^[150] The evidence for glucosamine sulfate having an effect on osteoarthritis progression is somewhat unclear and if present likely modest.^[151] The Osteoarthritis Research Society International recommends that glucosamine be discontinued if no effect is observed after six months^[152] and the National Institute for Health and Care Excellence no longer recommends its use.^[10] Despite the difficulty in determining the efficacy of glucosamine, it remains a treatment option.^[153] The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends glucosamine sulfate and chondroitin sulfate for knee osteoarthritis.^[154] Its use as a therapy for osteoarthritis is usually safe.^[153]^[155]

A 2015 Cochrane review of clinical trials of chondroitin found that most were of low quality, but that there was some evidence of short-term improvement in pain and few side effects; it does not appear to improve or maintain the health of affected joints.^[156]

Supplements

Avocado–soybean unsaponifiables (ASU) is an extract made from avocado oil and soybean oil^[157] sold under many brand names worldwide as a dietary supplement^[158] and as a prescription drug in France.^[159] A 2014 Cochrane review found that while ASU might help relieve pain in the short term for some people with osteoarthritis, it does not appear to improve or maintain the health of affected joints.^[157] The review noted a high-quality, two-year clinical trial comparing ASU to chondroitin – which has uncertain efficacy in osteoarthritis – with no difference between the two agents.^[157] The review also found there is insufficient evidence of ASU safety.^[157]

A few high-quality studies of Boswellia serrata show consistent, but small, improvements in pain and function.^[157] Curcumin,^[160] phytodolor,^[107] and s-adenosyl methionine (SAMe)^[107]^[76] may be effective in improving pain. A 2009 Cochrane review recommended against the routine use of SAMe, as there has not been sufficient high-quality clinical research to prove its effect.^[161] A 2021 review found that hydroxychloroquine (HCQ) had no benefit in reducing pain and improving physical function in hand or knee osteoarthritis, and the off-label use of HCQ for people with osteoarthritis should be discouraged.^[162] There is no evidence for the use of colchicine for treating the pain of hand or knee arthritis.^[163]

There is limited evidence to support the use of hyaluronan,^[164] methylsulfonylmethane,^[107] rose hip,^[107] capsaicin,^[107] or vitamin D.^[107]^[165]

Acupuncture and other interventions

While acupuncture leads to improvements in pain relief, this improvement is small and may be of questionable importance.^[166] Waiting list–controlled trials for peripheral joint osteoarthritis do show clinically relevant benefits, but these may be due to placebo effects.^[167]^[168] Acupuncture does not seem to produce long-term benefits.^[169]

Electrostimulation techniques such as TENS have been used for twenty years to treat osteoarthritis in the knee. However, there is no conclusive evidence to show that it reduces pain or disability.^[170] A Cochrane review of low-level laser therapy found unclear evidence of benefit,^[171] whereas another review found short-term pain relief for osteoarthritic knees.^[172]

Further research is needed to determine if balnotherapy for osteoarthritis (mineral baths or spa treatments) improves a person's quality of life or ability to function.^[173] The use of ice or cold packs may be beneficial; however, further research is needed.^[174] There is no evidence of benefit from placing hot packs on joints.^[174]

There is low quality evidence that therapeutic ultrasound may be beneficial for people with osteoarthritis of the knee; however, further research is needed to confirm and determine the degree and significance of this potential benefit.^[175]

Therapeutic ultrasound may relieve pain compared to conventional non-drug ultrasound however phonopheresis does not produce additional benefits to functional improvement. It is safe treatment to relieve pain and improve physical function in patients with knee osteoarthritis.^[176]

Continuous and pulsed ultrasound modes (especially 1 MHz, 2.5 W/cm², 15min/ session, 3 session/ week, during 8 weeks protocol) may be effective in improving patients physical function and pain.^[177]

There is weak evidence suggesting that electromagnetic field treatment may result in moderate pain relief; however, further research is necessary and it is not known if electromagnetic field treatment can improve quality of life or function.^[178]

Viscosupplementation for osteoarthritis of the knee may have positive effects on pain and function at 5 to 13 weeks post-injection.^[179]

Epidemiology

Globally, as of 2010^[update], approximately 250 million people had osteoarthritis of the knee (3.6% of the population).^[181]^[182] Hip osteoarthritis affects about 0.85% of the population.^[181]

As of 2004^[update], osteoarthritis globally causes moderate to severe disability in 43.4 million people.^[183] Together, knee and hip osteoarthritis had a ranking for disability globally of 11th among 291 disease conditions assessed.^[181]

Middle East and North Africa (MENA)

In the Middle East and North Africa from 1990 to 2019, the prevalence of people with hip osteoarthritis increased three–fold over the three decades, a total of 1.28 million cases.^[184] It increased 2.88-fold, from 6.16 million cases to 17.75 million, between 1990 and 2019 for knee osteoarthritis.^[185] Hand osteoarthritis in MENA also increased 2.7-fold, from 1.6 million cases to 4.3 million from 1990 to 2019.^[186]

USA

As of 2012^[update], osteoarthritis affected 52.5 million people in the United States, approximately 50% of whom were 65 years or older.^[187] It is estimated that 80% of the population have radiographic evidence of osteoarthritis by age 65, although only 60% of those will have symptoms.^[188] The rate of osteoarthritis in the United States is forecast to be 78 million (26%) adults by 2040.^[187]

In the United States, there were approximately 964,000 hospitalizations for osteoarthritis in 2011, a rate of 31 stays per 10,000 population.^[189] With an aggregate cost of $14.8 billion ($15,400 per stay), it was the second-most expensive condition seen in U.S. hospital stays in 2011. By payer, it was the second-most costly condition billed to Medicare and private insurance.^[190]^[191]

Europe

In Europe, the number of individuals affected by osteoarthritis has increased from 27.9 million in 1990 to 50.8 million in 2019. Hand osteoarthritis was the second most prevalent type, affecting an estimated 12.5 million people. In 2019, Knee osteoarthritis was the 18th most common cause of years lived with disability (YLDs) in Europe, accounting for 1.28% of all YLDs. This has increased from 1.12% in 1990.^[192]

India

In India, the number of individuals affected by osteoarthritis has increased from 23.46 million in 1990 to 62.35 million in 2019. Knee osteoarthritis was the most prevalent type of osteoarthritis, followed by hand osteoarthritis. In 2019, osteoarthritis was the 20th most common cause of years lived with disability (YLDs) in India, accounting for 1.48% of all YLDs, which increased from 1.25% and 23rd most common cause in 1990.^[193]

History

Etymology

Osteoarthritis is derived from the prefix osteo- (from Template:Lang-grc) combined with arthritis (from ἀρθρῖτῐς, arthrîtis, lit. ''of or in the joint''), which is itself derived from arthr- (from ἄρθρον, árthron, lit. ''joint, limb'') and -itis (from -ῖτις, -îtis, lit. ''pertaining to''), the latter suffix having come to be associated with inflammation.^[194] The -itis of osteoarthritis could be considered misleading as inflammation is not a conspicuous feature. Some clinicians refer to this condition as osteoarthrosis to signify the lack of inflammatory response,^[195] the suffix -osis (from -ωσις, -ōsis, lit. ''(abnormal) state, condition, or action'') simply referring to the pathosis itself.

Other animals

Osteoarthritis has been reported in several species of animals all over the world, including marine animals and even some fossils; including but not limited to: cats, many rodents, cattle, deer, rabbits, sheep, camels, elephants, buffalo, hyena, lions, mules, pigs, tigers, kangaroos, dolphins, dugong, and horses.^[196]

Osteoarthritis has been reported in fossils of the large carnivorous dinosaur Allosaurus fragilis.^[197]

Research

Therapies

Pharmaceutical agents that will alter the natural history of disease progression by arresting joint structural change and ameliorating symptoms are termed as disease modifying therapy (DMOAD).^[62] Therapies under investigation include the following:

Strontium ranelate – may decrease degeneration in osteoarthritis and improve outcomes^[198]^[199]
Gene therapy – Gene transfer strategies aim to target the disease process rather than the symptoms.^[200] Cell-mediated gene therapy is also being studied.^[201]^[202] One version was approved in South Korea for the treatment of moderate knee osteoarthritis, but later revoked for the mislabeling and the false reporting of an ingredient used.^[203]^[204] The drug was administered intra-articularly.^[204]

Cause

As well as attempting to find disease-modifying agents for osteoarthritis, there is emerging evidence that a system-based approach is necessary to find the causes of osteoarthritis.^[205]

Diagnostic biomarkers

Guidelines outlining requirements for inclusion of soluble biomarkers in osteoarthritis clinical trials were published in 2015,^[206] but there are no validated biomarkers used clinically to detect osteoarthritis, as of 2021.^[207]^[208]

A 2015 systematic review of biomarkers for osteoarthritis looking for molecules that could be used for risk assessments found 37 different biochemical markers of bone and cartilage turnover in 25 publications.^[209] The strongest evidence was for urinary C-terminal telopeptide of type II collagen (uCTX-II) as a prognostic marker for knee osteoarthritis progression, and serum cartilage oligomeric matrix protein (COMP) levels as a prognostic marker for incidence of both knee and hip osteoarthritis. A review of biomarkers in hip osteoarthritis also found associations with uCTX-II.^[210] Procollagen type II C-terminal propeptide (PIICP) levels reflect type II collagen synthesis in body and within joint fluid PIICP levels can be used as a prognostic marker for early osteoarthritis.^[211]

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@@ Line 135: / Line 135: @@
 ===Lifestyle changes===
-For overweight people, [[weight loss]] may help relieve hip arthritis.<ref name="Hip Osteoarthritis 2009"/> Weight loss and exercise provide long-term treatment and are advocated in people with osteoarthritis.<ref name="pmid19207981">{{cite journal | vauthors = Hunter DJ, Eckstein F | title=Exercise and osteoarthritis | journal= [[Journal of Anatomy]] | volume=214 | issue=2 | pages=197–207 | year=2009 | doi= 10.1111/j.1469-7580.2008.01013.x | pmc=2667877 | pmid=19207981}}</ref> High impact exercise can increase the risk of joint injury, whereas low or moderate impact exercise, such as walking or swimming, is safer for people with osteoarthritis.<ref name="pmid19207981" /> '''A study has suggested that an increase in blood calcium levels had a positive impact on osteoarthritis. An adequate dietary calcium intake and regular weight-bearing exercise can increase calcium levels and is helpful in preventing osteoarthritis in the general population. There is also a weak protective effect factor of LDL (low-density lipoprotein) cholesterol. However, this is not recommended since an increase in LDL has an increased chance of cardiovascular comorbidities.''' <ref>{{Cite journal |last=Ho |first=Justin |last2=Mak |first2=Christopher |last3=Sharma |first3=Vivek |last4=To |first4=Kendrick |last5=Khan |first5=Wasim |date=2022-10-07 |title=Mendelian Randomization Studies of Lifestyle-Related Risk Factors for Osteoarthritis: A PRISMA Review and Meta-Analysis |url=https://www.mdpi.com/1422-0067/23/19/11906 |journal=International Journal of Molecular Sciences |language=en |volume=23 |issue=19 |pages=11906 |doi=10.3390/ijms231911906 |issn=1422-0067 |pmc=PMC9570129 |pmid=36233208}}</ref>
+For overweight people, [[weight loss]] may help relieve hip arthritis.<ref name="Hip Osteoarthritis 2009"/> Weight loss and exercise provide long-term treatment and are advocated in people with osteoarthritis.<ref name="pmid19207981">{{cite journal | vauthors = Hunter DJ, Eckstein F | title=Exercise and osteoarthritis | journal= [[Journal of Anatomy]] | volume=214 | issue=2 | pages=197–207 | year=2009 | doi= 10.1111/j.1469-7580.2008.01013.x | pmc=2667877 | pmid=19207981}}</ref> High impact exercise can increase the risk of joint injury, whereas low or moderate impact exercise, such as walking or swimming, is safer for people with osteoarthritis.<ref name="pmid19207981" /> A study has suggested that an increase in blood calcium levels had a positive impact on osteoarthritis. An adequate dietary calcium intake and regular weight-bearing exercise can increase calcium levels and is helpful in preventing osteoarthritis in the general population. There is also a weak protective effect factor of LDL (low-density lipoprotein) cholesterol. However, this is not recommended since an increase in LDL has an increased chance of cardiovascular comorbidities. <ref>{{Cite journal |last=Ho |first=Justin |last2=Mak |first2=Christopher |last3=Sharma |first3=Vivek |last4=To |first4=Kendrick |last5=Khan |first5=Wasim |date=2022-10-07 |title=Mendelian Randomization Studies of Lifestyle-Related Risk Factors for Osteoarthritis: A PRISMA Review and Meta-Analysis |url=https://www.mdpi.com/1422-0067/23/19/11906 |journal=International Journal of Molecular Sciences |language=en |volume=23 |issue=19 |pages=11906 |doi=10.3390/ijms231911906 |issn=1422-0067 |pmc=PMC9570129 |pmid=36233208}}</ref>
 As an adjunct to these lifestyle changes, use of analgesia, intra-articular cortisone injection and consideration of hyaluronic acids and platelet-rich plasma are recommended for pain relief in people with knee osteoarthritis.<ref>{{cite journal | vauthors = Charlesworth J, Fitzpatrick J, Perera NK, Orchard J | title = Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee | journal = BMC Musculoskeletal Disorders | volume = 20 | issue = 1 | pages = 151 | date = April 2019 | pmid = 30961569 | pmc = 6454763 | doi = 10.1186/s12891-019-2525-0 | doi-access = free }}</ref> Education is helpful in self-management of arthritis, and can provide coping methods leading to about 20% more pain relief when compared to NSAIDs alone.<ref name="Hip Osteoarthritis 2009">{{cite journal | vauthors = Cibulka MT, White DM, Woehrle J, Harris-Hayes M, Enseki K, Fagerson TL, Slover J, Godges JJ | title = Hip pain and mobility deficits--hip osteoarthritis: clinical practice guidelines linked to the international classification of functioning, disability, and health from the orthopaedic section of the American Physical Therapy Association | journal = The Journal of Orthopaedic and Sports Physical Therapy | volume = 39 | issue = 4 | pages = A1-25 | date = April 2009 | pmid = 19352008 | pmc = 3963282 | doi = 10.2519/jospt.2009.0301 }}</ref>

Classification	D ICD-10: M15-M19, M47 ICD-9-CM: 715 OMIM: 165720 MeSH: D010003 DiseasesDB: 9313 SNOMED CT: 227588009
External resources	MedlinePlus: 000423 eMedicine: med/1682 orthoped/427 pmr/93 radio/492 Patient UK: Osteoarthritis