PCTK2: Difference between revisions

CDK17
Identifiers
Aliases	CDK17, PCTAIRE2, PCTK2, cyclin-dependent kinase 17, cyclin dependent kinase 17
External IDs	OMIM: 603440; MGI: 97517; HomoloGene: 55666; GeneCards: CDK17; OMA:CDK17 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	96,400,480 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,267,071 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Region I of hippocampus proper; ; Brodmann area 23; ; external globus pallidus; ; Achilles tendon; ; visceral pleura; ; postcentral gyrus; ; vena cava; ; superior frontal gyrus; ; middle temporal gyrus;
	Top expressed in
	olfactory tubercle; ; Region I of hippocampus proper; ; piriform cortex; ; nucleus accumbens; ; subiculum; ; primary motor cortex; ; temporal lobe; ; amygdala; ; prefrontal cortex; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity;
Cellular component	nucleus; cytoplasm;
Biological process	protein phosphorylation; phosphorylation; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5128
	237459
	ENSG00000059758
	ENSMUSG00000020015
	Q00537
	Q8K0D0
	NM_001170464; NM_002595
	NM_146239
	NP_001163935; NP_002586
	NP_666351
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 12:16, 8 April 2024

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the CDK17 gene.^[5]^[6]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000059758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020015 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons". Eur J Biochem. 249 (2): 481–8. doi:10.1111/j.1432-1033.1997.t01-1-00481.x. PMID 9370357.
^ ^a ^b "Entrez Gene: PCTK2 PCTAIRE protein kinase 2".

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.
Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000059758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020015 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9370357-5] Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons". Eur J Biochem. 249 (2): 481–8. doi:10.1111/j.1432-1033.1997.t01-1-00481.x. PMID 9370357.

[entrez-6] "Entrez Gene: PCTK2 PCTAIRE protein kinase 2".

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[2]

[3]

[4]

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[6]

@@ Line 16: / Line 16: @@
 *{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | author2=Feingold EA  | author3=Grouse LH  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
 *{{cite journal  | author=Conte N |title=TACC1-chTOG-Aurora A protein complex in breast cancer |journal=Oncogene |volume=22 |issue= 50 |pages= 8102–16 |year= 2003 |pmid= 14603251 |doi= 10.1038/sj.onc.1206972  | author2=Delaval B  | author3=Ginestier C  | last4=Ferrand  | first4=Alexia  | last5=Isnardon  | first5=Daniel  | last6=Larroque  | first6=Christian  | last7=Prigent  | first7=Claude  | last8=Séraphin  | first8=Bertrand  | last9=Jacquemier  | first9=Jocelyne | doi-access=  |s2cid=10536264 }}
-*{{cite journal  | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051  | author2=Smith FD  | author3=Stark C  | last4=Wells  | first4=Clark D.  | last5=Fawcett  | first5=James P.  | last6=Kulkarni  | first6=Sarang  | last7=Metalnikov  | first7=Pavel  | last8=O'Donnell  | first8=Paul  | last9=Taylor  | first9=Paul |s2cid=2371325 | doi-access=free  }}
+*{{cite journal  | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051  | author2=Smith FD  | author3=Stark C  | last4=Wells  | first4=Clark D.  | last5=Fawcett  | first5=James P.  | last6=Kulkarni  | first6=Sarang  | last7=Metalnikov  | first7=Pavel  | last8=O'Donnell  | first8=Paul  | last9=Taylor  | first9=Paul |s2cid=2371325 | doi-access=free  |bibcode=2004CBio...14.1436J }}
 *{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  | author2=Wagner L  | author3=Feingold EA  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
 *{{cite journal  | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776  | author2=Brown KR  | author3=Ozdamar B  | last4=Bose  | first4=R  | last5=Liu  | first5=Z  | last6=Donovan  | first6=RS  | last7=Shinjo  | first7=F  | last8=Liu  | first8=Y  | last9=Dembowy  | first9=J |bibcode=2005Sci...307.1621B |s2cid=39457788 }}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Latest revision as of 12:16, 8 April 2024

References

Further reading