Autoimmune skin diseases in dogs: Difference between revisions
Added sections "diagnosis" and "treatment" and copied some information from User:Chairomai/Autoimmune skin diseases in dogs |
Moved some information around and copied from User:Chairomai/Autoimmune skin diseases in dogs |
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== Clinical symptoms == |
== Clinical symptoms == |
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[[File:Canine pemphigus foliaceus 3.jpg|thumb|250px|'''Pemphigus foliaceus''' in [[dogs]]: hair loss occurs, skin becomes red, and itchy.]] |
[[File:Canine pemphigus foliaceus 3.jpg|thumb|250px|'''Pemphigus foliaceus''' in [[dogs]]: hair loss occurs, skin becomes red, and itchy.]] |
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Dogs suffering from autoimmune diseases of the [[skin]] may experience a variety of symptoms, including persistent [[itching]] and scratching, lesions, wounds, blisters, and other skin damage, as well as loss of skin [[pigment]].<ref name="Autoimun" /> Two cases of autoimmune diseases that are often found |
Dogs suffering from autoimmune diseases of the [[skin]] may experience a variety of symptoms, including persistent [[itching]] and scratching, lesions, wounds, blisters, and other skin damage, as well as loss of skin [[pigment]].<ref name="Autoimun" /> Two cases of autoimmune diseases that are often found include ''[[Discoid lupus erythematosus]]'' (DLE) and ''[[Pemphigus]]''. DLE can develop into [[Systemic lupus erythematosus|Systemic Lupus Erythematosus]] (SLE).<ref name="Mueller">[http://www.ivis.org/proceedings/scivac/2005/Mueller1_en.pdf?LA=1 Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC]</ref> The initial stage of DLE is marked by a loss of skin [[pigment]]. The skin becomes red and [[Ulcer (dermatology)|sore]]s appear on the [[nose]]. The [[palate]] can undergo [[erosion]], ulceration, and injury to the nasal palate, as well as damage to the nostrils and the tissue around the eyes and ears. In [[chronic condition|chronic]] and severe cases, visual scar tissue often occurs.<ref name="Mueller" /> Most symptoms occur after the outer epidermis and inner dermis of the skin are affected by the disease. When this happens, the layers of the skin begin to separate, leading to painful lesions and pustules. The compromised integrity of the skin barrier not only exacerbates the discomfort experienced by the dog, but also heightens the risk of secondary bacterial infections. The weakening of the skin’s protective layers forms an environment susceptible to microbial infiltration, which could lead to severe complications. Intervening within an earlier time frame and targeted management strategies are essential to minimize further adverse effects.<ref>{{cite journal | doi=10.1186/s12917-019-2003-9 | doi-access=free | title=Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: Vitiligo and the uveodermatological syndrome: A comprehensive review | date=2019 | last1=Tham | first1=Heng L. | last2=Linder | first2=Keith E. | last3=Olivry | first3=Thierry | journal=BMC Veterinary Research | volume=15 | issue=1 | page=251 | pmid=31324191 | pmc=6639964 }}</ref> |
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Another autoimmune skin disease which can occur in dogs is vitiligo. The exact prevalence of this disease in dogs is currently unknown, as it is likely under-reported.'''<ref>{{Cite journal |last1=Tham |first1=Heng L. |last2=Linder |first2=Keith E. |last3=Olivry |first3=Thierry |date=2019-07-19 |title=Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review |journal=BMC Veterinary Research |volume=15 |issue=1 |pages=251 |doi=10.1186/s12917-019-2003-9 |issn=1746-6148 |pmc=6639964 |pmid=31324191 |doi-access=free}}</ref>''' Vitiligo can be found in humans and a variety of animals, including cats, horses, and dogs. Vitiligo is a type of autoimmune disease that damages melanocytes in the skin, lips, and oral cavity. Melanocytes are cells that contain pigments such as melanin. These pigments give rise to an organism's phenotype, which determines skin and hair color.'''<ref>{{Cite journal |last1=Yamaguchi |first1=Yuji |last2=Hearing |first2=Vincent J. |date=May 2014 |title=Melanocytes and Their Diseases |journal=Cold Spring Harbor Perspectives in Medicine |volume=4 |issue=5 |pages=a017046 |doi=10.1101/cshperspect.a017046 |issn=2157-1422 |pmc=3996377 |pmid=24789876}}</ref>''' Melanocytes are also found in other parts of the body, such as the oral mucosa, eye, cochlea, and the meninges. Certain breeds of dogs have a higher chance of developing Vitiligo based on their genetics. These breeds include Rottweilers, German Shepherds, Old English Sheepdogs, Doberman Pinchers, Dachshunds, and German Shorthaired Pointers.<ref>{{Cite web |title=ScienceDirect.com {{!}} Science, health and medical journals, full text articles and books. |url=https://www.sciencedirect.com/?ref=pdf_download&fr=RR-11&rr=85b34e9bf99b394c |access-date=2024-02-25 |website=www.sciencedirect.com}}</ref> In addition to Vitiligo, there are other autoimmune diseases that target melanocytes, such as Vogt-Koyanagi-Harada (VKH) syndrome, and Uveodermatological (UDS) syndrome.'''<ref>{{Cite journal |last1=Tham |first1=Heng L. |last2=Linder |first2=Keith E. |last3=Olivry |first3=Thierry |date=2019-07-19 |title=Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review |journal=BMC Veterinary Research |volume=15 |issue=1 |pages=251 |doi=10.1186/s12917-019-2003-9 |doi-access=free |pmid=31324191 |pmc=6639964 |issn=1746-6148}}</ref>''' |
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When pemphigus occurs in humans, the skin will begin to blister due to antibodies attacking the adhesive proteins in epidermal cells, which causes them to separate. Different types of pemphigus can be identified based on the depth of separation present in the skin. Many forms of pemphigus can be identified in dogs using methods similar to those employed for humans.<ref>{{Cite journal |last=Olivry |first=Thierry |date=2006-09-04 |title=A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus |url=https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3164.2006.00540.x |journal=Veterinary Dermatology |volume=17 |issue=5 |pages=291–305 |doi=10.1111/j.1365-3164.2006.00540.x |pmid=16961814 |issn=0959-4493}}</ref> In infections caused by ''[[Pemphigus vulgaris]],'' lesions are usually evident in the oral cavity of the dog.<ref name="Mueller" /> Sometimes symptoms are characterized by [[lymphadenopathy]], which is characterized by loss of appetite, weakness, [[fever]], and in rare cases, [[sepsis]].<ref name="Mueller" /> ''[[Pemphigus foliaceus]]'' is the most common autoimmune skin disease in dogs, making up around one-third of all canine autoimmune disorders.<ref name=":02">{{Cite web |date=2022-05-16 |title=Canine skin autoimmune diseases |url=https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/health-info/canine-skin-autoimmune-diseases |access-date=2024-03-03 |website=Cornell University College of Veterinary Medicine |language=en}}</ref> This disease usually affects areas of the ears and face.<ref name="Mueller2">[http://www.ivis.org/proceedings/scivac/2005/Mueller1_en.pdf?LA=1 Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC]</ref> Early symptoms are characterized by [[depigmentation]] of the nasal palate, dorsal cleft in the [[mouth]], the [[ear]], and the periocular area around the eye. Itching, pain, and weakness of the body have been observed in some cases. Other symptoms of ''Pemphigus foliaceus'' include hair loss, formation of pustules, and erosions with ulcers. These symptoms can appear on the dog's feet, groin area, and trunk if left untreated.<ref name=":0">{{Cite web |date=2022-05-16 |title=Canine skin autoimmune diseases |url=https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/health-info/canine-skin-autoimmune-diseases |access-date=2024-03-03 |website=Cornell University College of Veterinary Medicine |language=en}}</ref> |
When pemphigus occurs in humans, the skin will begin to blister due to antibodies attacking the adhesive proteins in epidermal cells, which causes them to separate. Different types of pemphigus can be identified based on the depth of separation present in the skin. Many forms of pemphigus can be identified in dogs using methods similar to those employed for humans.<ref>{{Cite journal |last=Olivry |first=Thierry |date=2006-09-04 |title=A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus |url=https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3164.2006.00540.x |journal=Veterinary Dermatology |volume=17 |issue=5 |pages=291–305 |doi=10.1111/j.1365-3164.2006.00540.x |pmid=16961814 |issn=0959-4493}}</ref> In infections caused by ''[[Pemphigus vulgaris]],'' lesions are usually evident in the oral cavity of the dog.<ref name="Mueller" /> Sometimes symptoms are characterized by [[lymphadenopathy]], which is characterized by loss of appetite, weakness, [[fever]], and in rare cases, [[sepsis]].<ref name="Mueller" /> ''[[Pemphigus foliaceus]]'' is the most common autoimmune skin disease in dogs, making up around one-third of all canine autoimmune disorders.<ref name=":02">{{Cite web |date=2022-05-16 |title=Canine skin autoimmune diseases |url=https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/health-info/canine-skin-autoimmune-diseases |access-date=2024-03-03 |website=Cornell University College of Veterinary Medicine |language=en}}</ref> This disease usually affects areas of the ears and face.<ref name="Mueller2">[http://www.ivis.org/proceedings/scivac/2005/Mueller1_en.pdf?LA=1 Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC]</ref> Early symptoms are characterized by [[depigmentation]] of the nasal palate, dorsal cleft in the [[mouth]], the [[ear]], and the periocular area around the eye. Itching, pain, and weakness of the body have been observed in some cases. Other symptoms of ''Pemphigus foliaceus'' include hair loss, formation of pustules, and erosions with ulcers. These symptoms can appear on the dog's feet, groin area, and trunk if left untreated.<ref name=":0">{{Cite web |date=2022-05-16 |title=Canine skin autoimmune diseases |url=https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/health-info/canine-skin-autoimmune-diseases |access-date=2024-03-03 |website=Cornell University College of Veterinary Medicine |language=en}}</ref> |
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== Treatment == |
== Treatment == |
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For most autoimmune skin diseases, it is imperative to begin treatment as early as possible, as the progression of the disease can lead to severe complications and even death.<ref name=":12">{{Cite journal |last=Fukushima |first=K. |date=1982-04 |title=Pathogenesis of pemphigus vulgaris in dog and man - a review |url=https://pubmed.ncbi.nlm.nih.gov/17422133 |journal=The Canadian Veterinary Journal = La Revue Veterinaire Canadienne |volume=23 |issue=4 |pages=135–137 |issn=0008-5286 |pmc=1790145 |pmid=17422133}}</ref> |
For most autoimmune skin diseases, it is imperative to begin treatment as early as possible, as the progression of the disease can lead to severe complications and even death.<ref name=":12">{{Cite journal |last=Fukushima |first=K. |date=1982-04 |title=Pathogenesis of pemphigus vulgaris in dog and man - a review |url=https://pubmed.ncbi.nlm.nih.gov/17422133 |journal=The Canadian Veterinary Journal = La Revue Veterinaire Canadienne |volume=23 |issue=4 |pages=135–137 |issn=0008-5286 |pmc=1790145 |pmid=17422133}}</ref> Treatment for many diseases usually involves the use of immunosuppressants such as glucocorticoids.<ref name=":23">{{Cite journal |last=Bizikova |first=Petra |last2=Linder |first2=Keith E. |last3=Anderson |first3=Jamie G. |date=2023-06-01 |title=Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider? |url=https://avmajournals.avma.org/view/journals/javma/261/S1/javma.22.12.0573.xml |journal=Journal of the American Veterinary Medical Association |language=en |volume=261 |issue=S1 |pages=S48–S57 |doi=10.2460/javma.22.12.0573}}</ref> |
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==See also== |
==See also== |
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Revision as of 20:55, 15 April 2024
Autoimmune skin diseases occur when the immune system of an infected animal attacks its own skin.[1] In dogs, autoimmune skin diseases are usually not detected until visible symptoms appear, which differs from detection in humans who are able to verbally express their concerns.[2] Genetics, nutrition, and external environmental factors all collectively contribute to increasing the probability an autoimmune skin disease occurring.[3] The severity of symptoms varies based on the specific disease present and how far it has progressed. Diagnosis often requires the onset of visible symptoms and for a biopsy to be performed. For many diseases, the condition itself cannot be cured, but a veterinarian can prescribe medications and other forms of treatment to help manage the symptoms of the dog.[4]
Overview
The immune system has the ability to differentiate between the cells of the body and foreign cells.[5] However, in dogs affected by an autoimmune disease, the immune system loses the ability to make this distinction, causing the immune system to attack the body.[6] Autoimmune diseases in the base layer of the epidermis are characterized by damage to the connective tissue and vesicle formation located below the epidermis layer and the dermis layer below it.[7][8]
Clinical symptoms
Dogs suffering from autoimmune diseases of the skin may experience a variety of symptoms, including persistent itching and scratching, lesions, wounds, blisters, and other skin damage, as well as loss of skin pigment.[6] Two cases of autoimmune diseases that are often found include Discoid lupus erythematosus (DLE) and Pemphigus. DLE can develop into Systemic Lupus Erythematosus (SLE).[9] The initial stage of DLE is marked by a loss of skin pigment. The skin becomes red and sores appear on the nose. The palate can undergo erosion, ulceration, and injury to the nasal palate, as well as damage to the nostrils and the tissue around the eyes and ears. In chronic and severe cases, visual scar tissue often occurs.[9] Most symptoms occur after the outer epidermis and inner dermis of the skin are affected by the disease. When this happens, the layers of the skin begin to separate, leading to painful lesions and pustules. The compromised integrity of the skin barrier not only exacerbates the discomfort experienced by the dog, but also heightens the risk of secondary bacterial infections. The weakening of the skin’s protective layers forms an environment susceptible to microbial infiltration, which could lead to severe complications. Intervening within an earlier time frame and targeted management strategies are essential to minimize further adverse effects.[10]
Another autoimmune skin disease which can occur in dogs is vitiligo. The exact prevalence of this disease in dogs is currently unknown, as it is likely under-reported.[11] Vitiligo can be found in humans and a variety of animals, including cats, horses, and dogs. Vitiligo is a type of autoimmune disease that damages melanocytes in the skin, lips, and oral cavity. Melanocytes are cells that contain pigments such as melanin. These pigments give rise to an organism's phenotype, which determines skin and hair color.[12] Melanocytes are also found in other parts of the body, such as the oral mucosa, eye, cochlea, and the meninges. Certain breeds of dogs have a higher chance of developing Vitiligo based on their genetics. These breeds include Rottweilers, German Shepherds, Old English Sheepdogs, Doberman Pinchers, Dachshunds, and German Shorthaired Pointers.[13] In addition to Vitiligo, there are other autoimmune diseases that target melanocytes, such as Vogt-Koyanagi-Harada (VKH) syndrome, and Uveodermatological (UDS) syndrome.[14]
When pemphigus occurs in humans, the skin will begin to blister due to antibodies attacking the adhesive proteins in epidermal cells, which causes them to separate. Different types of pemphigus can be identified based on the depth of separation present in the skin. Many forms of pemphigus can be identified in dogs using methods similar to those employed for humans.[15] In infections caused by Pemphigus vulgaris, lesions are usually evident in the oral cavity of the dog.[9] Sometimes symptoms are characterized by lymphadenopathy, which is characterized by loss of appetite, weakness, fever, and in rare cases, sepsis.[9] Pemphigus foliaceus is the most common autoimmune skin disease in dogs, making up around one-third of all canine autoimmune disorders.[16] This disease usually affects areas of the ears and face.[17] Early symptoms are characterized by depigmentation of the nasal palate, dorsal cleft in the mouth, the ear, and the periocular area around the eye. Itching, pain, and weakness of the body have been observed in some cases. Other symptoms of Pemphigus foliaceus include hair loss, formation of pustules, and erosions with ulcers. These symptoms can appear on the dog's feet, groin area, and trunk if left untreated.[18]
Disease incidence process
The immune system functions in many ways to eliminate foreign substances and particles introduced to the body. This revolves around T-cell differentiation, where mature T-cells with receptors for non-self cells target foreign antigens and act with other cells to dispose of them.[19] There are two mechanisms of tolerance found in the immune system.[7] The first mechanism is positive selection by the thymus, where only T cells are selected. T cells recognize peptides in the Histocompatibility Complex (MHC).[7] The second mechanism is negative selection, where T cells that recognize self-antigens with too high an affinity are removed through the process of apoptosis and are not allowed to enter the body's circulation.
Diagnosis
Since many autoimmune skin diseases have similar symptoms and usually affect the oral cavity, a biopsy must often be performed in order to correctly diagnose the disease.[20]
Treatment
For most autoimmune skin diseases, it is imperative to begin treatment as early as possible, as the progression of the disease can lead to severe complications and even death.[21] Treatment for many diseases usually involves the use of immunosuppressants such as glucocorticoids.[22]
See also
References
- ^ Gershwin, Laurel J. (March 2018). "Current and Newly Emerging Autoimmune Diseases". Veterinary Clinics of North America: Small Animal Practice. 48 (2): 323–338. doi:10.1016/j.cvsm.2017.10.010. ISSN 0195-5616. PMID 29248206.
- ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. ISSN 1746-6148. PMC 6639964. PMID 31324191.
- ^ Gershwin, Laurel J. (May 2010). "Autoimmune Diseases in Small Animals". Veterinary Clinics of North America: Small Animal Practice. 40 (3): 439–457. doi:10.1016/j.cvsm.2010.02.003. PMID 20471527.
- ^ Fukushima, K. (April 1982). "Pathogenesis of pemphigus vulgaris in dog and man - a review". The Canadian Veterinary Journal = la Revue Veterinaire Canadienne. 23 (4): 135–137. ISSN 0008-5286. PMC 1790145. PMID 17422133.
- ^ "Immune system", Wikipedia, 2019-10-30, retrieved 2019-11-09
- ^ a b "Auto-immune Diseases". Archived from the original on 2019-10-30. Retrieved 2019-10-27.
- ^ a b c Papadogiannakis EI. 2005. Contemporary aspects of the immunopathogenesis of autoimmune diseases of the epidermal basement membrane in the dog. The Journal of the Hellenic Veterinary Medical Society 56(1) p 27-31.
- ^ "Structure of the Skin in Dogs - Dog Owners". Merck Veterinary Manual. Retrieved 2019-11-09.
- ^ a b c d Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC
- ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: Vitiligo and the uveodermatological syndrome: A comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. PMC 6639964. PMID 31324191.
- ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. ISSN 1746-6148. PMC 6639964. PMID 31324191.
- ^ Yamaguchi, Yuji; Hearing, Vincent J. (May 2014). "Melanocytes and Their Diseases". Cold Spring Harbor Perspectives in Medicine. 4 (5): a017046. doi:10.1101/cshperspect.a017046. ISSN 2157-1422. PMC 3996377. PMID 24789876.
- ^ "ScienceDirect.com | Science, health and medical journals, full text articles and books". www.sciencedirect.com. Retrieved 2024-02-25.
- ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. ISSN 1746-6148. PMC 6639964. PMID 31324191.
- ^ Olivry, Thierry (2006-09-04). "A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus". Veterinary Dermatology. 17 (5): 291–305. doi:10.1111/j.1365-3164.2006.00540.x. ISSN 0959-4493. PMID 16961814.
- ^ "Canine skin autoimmune diseases". Cornell University College of Veterinary Medicine. 2022-05-16. Retrieved 2024-03-03.
- ^ Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC
- ^ "Canine skin autoimmune diseases". Cornell University College of Veterinary Medicine. 2022-05-16. Retrieved 2024-03-03.
- ^ Sprent, Jonathan; Kishimoto, Hidehiro (2001). "The thymus and central tolerance". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 356 (1409): 609–616. doi:10.1098/rstb.2001.0846. PMC 1088448. PMID 11375064.
- ^ Bizikova, Petra; Linder, Keith E.; Anderson, Jamie G. (2023-06-01). "Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?". Journal of the American Veterinary Medical Association. 261 (S1): S48–S57. doi:10.2460/javma.22.12.0573.
- ^ Fukushima, K. (1982-04). "Pathogenesis of pemphigus vulgaris in dog and man - a review". The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. 23 (4): 135–137. ISSN 0008-5286. PMC 1790145. PMID 17422133.
{{cite journal}}: Check date values in:|date=(help) - ^ Bizikova, Petra; Linder, Keith E.; Anderson, Jamie G. (2023-06-01). "Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?". Journal of the American Veterinary Medical Association. 261 (S1): S48–S57. doi:10.2460/javma.22.12.0573.