LdcC RNA motif: Difference between revisions
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{{DISPLAYTITLE:''ldcC'' RNA motif}} |
{{DISPLAYTITLE:''ldcC'' RNA motif}} |
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The '''''ldcC'' RNA motif''' is a [[conserved sequence|conserved]] [[RNA]] structure that was [[Bioinformatics discovery of non-coding RNAs|discovered by bioinformatics]].<ref name="Weinberg2017b">{{cite journal |vauthors=Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR |title=Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions |journal=Nucleic Acids Res. |volume=45 |issue=18 |pages=10811–10823 |date=October 2017 |pmid=28977401 |pmc=5737381 |doi=10.1093/nar/gkx699 }}</ref> |
The '''''ldcC'' RNA motif''' is a [[conserved sequence|conserved]] [[RNA]] structure that was [[Bioinformatics discovery of non-coding RNAs|discovered by bioinformatics]].<ref name="Weinberg2017b">{{cite journal |vauthors=Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR |title=Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions |journal=Nucleic Acids Res. |volume=45 |issue=18 |pages=10811–10823 |date=October 2017 |pmid=28977401 |pmc=5737381 |doi=10.1093/nar/gkx699 }}</ref> |
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Latest revision as of 21:42, 6 October 2024
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The ldcC RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] ldcC motif RNAs are found in Bacillota and two species of Spirochaetota.
ldcC motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. The genes presumably regulated by ldcC RNAs are decarboxylases of arginine, ornithine, S-adenosylmethionine or other substrates. Endopeptidase C39A and potA (a transporter of spermidine/putrescine) is also relatively common. Thus, ldcC RNAs could regulate polyamine metabolism.
The ldcC motif might have a pseudoknot in its secondary structure, but it is unclear.
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
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