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| fields = {{ublist | [[Physical biochemistry]] }}
| fields = {{ublist | [[Physical biochemistry]] }}
| workplaces = {{ublist | [[Indian Institute of Science Education and Research, Pune]] | [[Tata Institute of Fundamental Research]] | [[National Centre for Biological Sciences]] }}
| workplaces = {{ublist | [[Indian Institute of Science Education and Research, Pune]] | [[Tata Institute of Fundamental Research]] | [[National Centre for Biological Sciences]] }}
| alma_mater = {{ublist | [[St. Xavier's College, Mumbai]] ([[University of Mumbai]]) }}
| alma_mater = {{ublist | [[St. Xavier's College, Mumbai]] ([[University of Mumbai]]) | [[Indian Institute of Technology, Chennai|IIT Chennai]] | [[Cornell University]] | [[Stanford University]] }}
| doctoral_advisor = George P. Hess<br>Robert Lesh Baldwin
| doctoral_advisor = George P. Hess<br>Robert Lesh Baldwin
| doctoral_students =
| doctoral_students =
| known_for = Studies on [[Protein folding]]
| known_for = Studies on [[Protein folding]]
| awards = 1996&nbsp;Birla Biology Award<br>2000&nbsp;[[Shanti Swarup Bhatnagar Prize]]<br>2011&nbsp;[[Indian Institute of Technology, Madras|IITM]] Distinguished Alumnus Award<br>2011&nbsp;[[Council of Scientific and Industrial Research|CSIR]] G. N. Ramachandran Gold Medal
| awards = G. N. Ramachandran Gold Medal
}}
}}

'''Jayant Bhalchandra Udgaonkar''' (born 1960) is a former [[Director (business)|Director]] and [[Professor]] of [[Biology]]<ref>{{Cite web |title=Jayant B. Udgaonkar - IISER Pune |url=https://www.iiserpune.ac.in/research/department/biology/people/faculty/regular-faculty/jayant-b-udgaonkar/348}}</ref> at the [[Indian Institute of Science Education and Research, Pune]]. Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see [[protein folding]]). In 2016, the [[Biophysical Journal]] published a retraction notice<ref> {{cite web |date= 7 December 2021 |title=Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/biophysj/pdf/S0006-3495(21)00952-8.pdf |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref> citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.<ref> {{cite web |date= 26 April 2016 |title=The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/action/showPdf?pii=S0006-3495%2816%2930068-6 |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref>
'''Jayant Bhalchandra Udgaonkar''' (born 1960) is an Indian biochemist, molecular biologist, and academic at the [[Indian Institute of Science Education and Research, Pune]]. He is the former Director of the [[Indian Institute of Science Education and Research, Pune]],<ref>{{cite news|last1=Nair|first1=Ardhra|title=New IISER director points at lack of funding for research|url=https://timesofindia.indiatimes.com/city/pune/new-iiser-director-points-at-lack-of-funding-for-research/articleshow/61426575.cms|access-date=1 November 2017|agency=The Times of India}}</ref><ref>{{cite news|title=Government clears appointment of top officials of four IIMs, IISER|url=http://www.hindustantimes.com/education/government-clears-appointment-of-top-officials-of-four-iims-iiser/story-Jp2JSglKUe8yOFgTcn1nVP.html|agency=Hindustan Times|date=19 September 2017}}</ref> and was previously a senior professor at the [[National Centre for Biological Sciences]].<ref name="Prof. Jayant B. Udgaonkar on NCBS">{{cite web | url=https://www.ncbs.res.in/faculty/student/133/1247 | title=Prof. Jayant B. Udgaonkar on NCBS | publisher=National Centre for Biological Sciences | date=2016 | access-date=15 October 2016}}</ref> A J.C. Bose National Fellow, he is known for his studies on [[protein folding]].<ref name="Brief Profile of the Awardee">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=95 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is an elected fellow of the [[Indian Academy of Sciences]],<ref name="Fellow profile - Udgaonkar">{{cite web | url=http://www.ias.ac.in/describe/fellow/Udgaonkar,_Prof._Jayant_Bhalchandra | title=Fellow profile - Udgaonkar | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}}</ref> [[Indian National Science Academy]]<ref name="Indian fellow - Udgaonkar">{{cite web | url=http://insaindia.res.in/detail.php?id=P02-1326 | title=Indian fellow - Udgaonkar | publisher=Indian National Science Academy | date=2016 | access-date=11 October 2016}}</ref> and [[The World Academy of Sciences]].<ref name="TWAS fellow">{{cite web | url=http://twas.org/member/udgaonkar-jayant | title=TWAS fellow | publisher=TWAS | date=2016 | access-date=15 October 2016}}</ref> The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards, in 2000, for his contributions to biological sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=201 | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is the son of noted scientist Padmabhushan [[Bhalchandra Udgaonkar]].<ref>{{cite book|last1=Phondke|first1=Bal|last2=Sheth|first2=Parul R.|last3=Naik-Satam|first3=Suhas|last4=Deshpande|first4=A.P.|title=B.M. Udgaonkar: Eminent Scientist and Educationist|date=2007|publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication|location=Mumbai|url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf}}</ref>

== Biography ==
== Biography ==
[[File:Protein structure.png|thumb|235px|Results of [[protein folding]] (This is not Dr. Udgaonkar`s own result).]]
[[File:Protein structure.png|thumb|235px|Results of [[protein folding]].]]
Jayant Udgaonkar, born on 22 March 1960, did his studies in protein folding chemistry at [[St. Xavier's College, Mumbai]].<ref name="Profile on NCBS">{{cite web |date=2016 |title=Profile on NCBS |url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf |access-date=15 October 2016 |publisher=National Centre for Biological Sciences}}</ref> Udgaonkar obtained his PhD in protein folding from [[Cornell University]] and carried out his postdoctoral research in protein folding from [[Stanford University]]. He propounded the protein folding hypothesis that ''initial [[hydrophobic collapse]]'' is the first stage in protein folding, which he demonstrated using a model protein and elucidated the various stages of protein folding and unfolding. His current work focuses on formation of [[amyloid|amyloid protein folding]].<ref name="Jayant Udgaonkar on Google Scholar">{{cite web |date=2016 |title=Jayant Udgaonkar on Google Scholar |url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en |access-date=16 October 2016 |work=Author profile |publisher=Google Scholar}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web |date=2016 |title=Jayant Udgaonkar on ResearchGate |url=https://www.researchgate.net/profile/Jayant_Udgaonkar |access-date=16 October 2016 |work=Author profile}}</ref>
Jayant Udgaonkar, born on 22 March 1960 in the Indian state of [[Maharashtra]], did his graduate studies in chemistry at [[St. Xavier's College, Mumbai]] during 1976–79 and secured his master's degree from the [[Indian Institute of Technology, Chennai]] in 1981.<ref name="Profile on NCBS">{{cite web | url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf | title=Profile on NCBS | publisher=National Centre for Biological Sciences | date=2016 | access-date=15 October 2016}}</ref> Moving to [[Cornell University]], he completed his doctoral studies under the guidance of George P. Hess to obtain a PhD for his thesis on [[acetylcholine receptor]] in 1986 after which did his post-doctoral studies under Robert Lesh Baldwin at [[Stanford University]] during 1986–89.<ref name="Indian fellow - Udgaonkar" /> Returning to India, he joined [[National Centre for Biological Sciences]] of [[Tata Institute of Fundamental Research]] as a reader in 1990 and has been serving as a senior professor since 2007. In between, he held the positions of an associate professor (1995–98), Dean (1997–2008), Head of Administration (1997–2008), Head of Research (1997–2008), Head of Technical Services (1998–2000) and a professor (1998–2007) at the institute and served as an honorary faculty member at the [[Jawaharlal Nehru Centre for Advanced Scientific Research]] in 1999.<ref name="Profile on NCBS" /> On 1 November 2017, he became the Director of the [[Indian Institute of Science Education and Research, Pune]], succeeding Prof. [[Krishna N. Ganesh]].<ref>{{cite web|title=Director|url=http://www.iiserpune.ac.in/the-institute/director|website=IISER Pune|access-date=1 November 2017}}</ref>


== Legacy ==
== Legacy ==
During his doctoral studies at Cornell University, Udgaonkar is known to have developed a protocol for rapid chemical kinetic studies at the cell surface.<ref name="Indian fellow - Udgaonkar" /> Later, while pursuing his post-doctoral studies, he developed methodologies for hydrogen exchange using [[Nuclear magnetic resonance spectroscopy]] for exploring the ''intermediates populating [[protein folding]] pathways''. Furthering his Stanford studies on protein folding at NCBS, he propounded the theory that ''initial [[hydrophobic collapse]]'' is the first stage in protein folding, which he demonstrated using a model protein [[barstar]] and elucidated the various transition stages of protein folding and unfolding.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=34 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }}</ref> He has also demonstrated that, contrary to the general understanding that a single dominant barrier slows down the protein folding, several distributed small barriers can also influence the reaction.<ref name="Indian fellow - Udgaonkar" /> His current work focuses on formation of [[amyloid]] [[fibrils]] and his research has shown multiple pathways of aggregation in the formation of amyloid fibrils of different morphologies.<ref name="Summary of Achievements">{{cite web | url=http://www.serb.gov.in/pdfs/research/Prof_Jayant_Udgaonkar.pdf | title=Summary of Achievements | publisher=SERB | date=2016 | access-date=16 October 2016}}</ref>
He is the son of noted scientist [[Bhalchandra Udgaonkar]].<ref>{{cite book|last1=Phondke|first1=Bal|last2=Sheth|first2=Parul R.|last3=Naik-Satam|first3=Suhas|last4=Deshpande|first4=A.P.|title=B.M. Udgaonkar: Eminent Scientist and Educationist|date=2007|publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication|location=Mumbai|url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf}}</ref>

⚫
== Awards and Honors ==
Udgaonkar has published a number of articles in peer reviewed journals detailing his researches,{{Refn|group=note|Please see Selected bibliography section}} [[Google Scholar]] and [[ResearchGate]], two online repositories of scientific articles, have listed several of them.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web | url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en | title=Jayant Udgaonkar on Google Scholar | publisher=Google Scholar | work=Author profile | date=2016 | access-date=16 October 2016}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web | url=https://www.researchgate.net/profile/Jayant_Udgaonkar | title=Jayant Udgaonkar on ResearchGate | work=Author profile | date=2016 | access-date=16 October 2016}}</ref> A former guest editor of the [[Current Opinion in Structural Biology]] of [[Elsevier]] (2013 and 2015) and a former editorial board member of ''Folding and Design'' (1996–98), he is an associate editor of the [[Biochemistry (journal)|Biochemistry]] journal<ref name="Profile on NCBS" /> and a member of the editorial board of ''Protein Engineering, Design and Selection'' (since 2003), an Oxford journal.<ref name="Editorial Office">{{cite web | url=http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | archive-url=https://web.archive.org/web/20160321195455/http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | url-status=dead | archive-date=2016-03-21 | title=Editorial Office | publisher=Oxford Journals | date=2016 | access-date=16 October 2016}}</ref> He is also a member of the Asia-Pacific International Molecular Biology Network since 2001 and has mentored several scholars in their doctoral researches.<ref name="Indian fellow - Udgaonkar" />
* Vigyan Shri Award under [[Rashtriya Vigyan Puraskar]] scheme (2024)<ref>{{cite web |title=Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees |url=https://awards.gov.in/Home/GoToIndex?filename=Award%2FCommunication%2F202488013634H24ZU2.pdf|website=awards.gov.in |publisher=CASU, Ministry of Home Affairs, Government of India |access-date=15 August 2024}}</ref><ref>{{cite news |title=Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition |url=https://economictimes.indiatimes.com/news/science/rashtriya-vigyan-puraskar-chandrayaan-3-team-and-32-others-selected-for-first-ever-edition-here-is-full-list/articleshow/112349033.cms?from=mdr |newspaper=The Economic Times | date=7 August 2024 |access-date=15 August 2024}}</ref>

* Udgaonkar stood first in the BSc chemistry examinations of the [[University of Mumbai]] in 1979 protein folding.<ref name="Profile on NCBS" />
⚫
== Awards and honors ==
Udgaonkar, who stood first in the BSc chemistry examinations of the [[University of Mumbai]] in 1979, received several scholarships and research fellowships including the National Merit Scholarship of the Government of India, Merit Scholarship of the Indian Institute of Technology, Madras, [[Jane Coffin Childs Memorial Fund for Medical Research]] fellowship, Biotechnology Career Fellowship of [[Rockefeller Foundation]], Golden Jubilee Biotechnology fellowship of the [[Department of Biotechnology]], Swarnajayanti fellowship of the [[Department of Science and Technology (India)|Department of Science and Technology]] and Senior Research fellowship of [[Wellcome Trust]] and is a J. C. Bose National Fellow of the [[Department of Science and Technology (India)|Department of Science and Technology]], the tenancy of the fellowship running from 2007 till 2017.<ref name="Profile on NCBS" /> He received the Birla Award in Biology in 1996 and the Indian Academy of Sciences elected him as a fellow in 1997.<ref name="Fellow profile - Udgaonkar" /> The [[Council of Scientific and Industrial Research]] awarded him the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards, in 2000.<ref name="View Bhatnagar Awardees" /> He became an elected fellow of the [[Indian National Science Academy]] in 2002 and [[The World Academy of Sciences]] elected him as a fellow in 2007.<ref name="TWAS fellow" />Vigyan Shri Award under [[Rashtriya Vigyan Puraskar]] scheme (2024).


== Selected bibliography ==
== Selected bibliography ==
* {{cite journal |title=Early folding intermediate of ribonuclease A. |author=Jayant B Udgaonkar, Robert L Baldwin |journal=Proceedings of the National Academy of Sciences |date=November 1990 |volume=87 |issue=21 |pages=8197–8201 |doi=10.1073/pnas.87.21.8197 |pmc=54922 |pmid=2236032 |bibcode=1990PNAS...87.8197U |doi-access=free}}
* {{cite journal | title=Pathogenic Mutations within the Disordered Palindromic Region of the Prion Protein Induce Structure Therein and Accelerate the Formation of Misfolded Oligomers | author=Sabareesan Ambadi Thody, Jayant B Udgaonkar | journal=Journal of Molecular Biology | date=August 2016 | volume=428 | issue=20 | doi=10.1016/j.jmb.2016.08.015 | pages=3935–3947 | pmid=27545411}}
* {{cite journal | title=How cooperative are protein folding and unfolding transitions?: Cooperativity in protein folding/unfolding reactions | author=Pooja Malhotra, Jayant B Udgaonkar | journal=Protein Science | date=August 2016 | doi=10.1002/pro.3015 | volume=25 | issue=11 | pages=1924–1941| pmc=5079258 | pmid=27522064}}
* {{cite journal | title=Microsecond Rearrangements of Hydrophobic Clusters in an Initially Collapsed Globule Prime Structure Formation during the Folding of a Small Protein | author=Rama Reddy Goluguri, Jayant B Udgaonkar | journal=Journal of Molecular Biology | date=June 2016 | volume=428 | issue=15 | doi=10.1016/j.jmb.2016.06.015 | pages=3102–3117 | pmid=27370109}}
*{{Cite journal|last1=Singh|first1=Jogender|last2=Kumar|first2=Harish|last3=Sabareesan|first3=Ambadi T.|last4=Udgaonkar|first4=Jayant B.|date=2014-12-03|title=Rational Stabilization of Helix 2 of the Prion Protein Prevents Its Misfolding and Oligomerization|journal=Journal of the American Chemical Society|language=en|volume=136|issue=48|pages=16704–16707|doi=10.1021/ja510964t|pmid=25407394|issn=0002-7863}}
*{{Cite journal|last1=Zaidi|first1=Faisal N.|last2=Nath|first2=Utpal|last3=Udgaonkar|first3=Jayant B.|date=December 1997|title=Multiple intermediates and transition states during protein unfolding|journal=Nature Structural Biology|volume=4|issue=12|pages=1016–1024|doi=10.1038/nsb1297-1016|pmid=9406552|s2cid=1692527|issn=1072-8368}}
* {{cite journal | title=Thermodynamics of denaturation of barstar: evidence for cold denaturation and evaluation of the interaction with guanidine hydrochloride | author=Vishwas R Agashe, Jayant B Udgaonkar | journal=Biochemistry | date=March 1995 | volume=34 | issue=10 | pages=3286–99 | doi=10.1021/bi00010a019| pmid=7880824 }}
* {{cite journal | title=Equilibrium unfolding studies of barstar: evidence for an alternative conformation which resembles a molten globule | author=Ritu Khurana, Jayant B Udgaonkar | journal=Biochemistry | date=January 1994 | volume=33 | issue=1 | pages=106–115 | doi=10.1021/bi00167a014| pmid=8286327 }}
* {{cite journal | title=Early folding intermediate of ribonuclease A. | author=Jayant B Udgaonkar, Robert L Baldwin | journal=Proceedings of the National Academy of Sciences | date=November 1990 | volume=87 | issue=21 | pages=8197–8201 | doi=10.1073/pnas.87.21.8197| pmc=54922 | pmid=2236032| bibcode=1990PNAS...87.8197U | doi-access=free }}

== See also ==
{{Div col}}
* [[Protein folding]]
* [[Amyloid]]
* [[Barstar]]
* [[Acetylcholine receptor]]
{{div col end}}
{{portal|India|Biology}}

== Notes ==
{{reflist|group=note}}


== References ==
== References ==
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{{DEFAULTSORT:Udgaonkar, Jayant B.}}
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Biological Science]]
[[Category:1960 births]]
[[Category:1960 births]]
[[Category:Scientists from Maharashtra]]
[[Category:Scientists from Maharashtra]]
[[Category:Marathi people]]
[[Category:Marathi people]]
[[Category:St. Xavier's College, Mumbai alumni]]
[[Category:St. Xavier's College, Mumbai alumni]]
[[Category:University of Mumbai alumni]]
[[Category:IIT Madras alumni]]
[[Category:Cornell University alumni]]
[[Category:Stanford University alumni]]
[[Category:National Centre for Biological Sciences faculty]]
[[Category:Tata Institute of Fundamental Research faculty]]
[[Category:Indian molecular biologists]]
[[Category:Indian biochemists]]
[[Category:Indian scientific authors]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:TWAS fellows]]
[[Category:Council of Scientific and Industrial Research]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:20th-century Indian biologists]]
[[Category:20th-century Indian chemists]]
[[Category:Indian Institute of Science Education and Research, Pune faculty]]

Revision as of 07:08, 25 December 2024

Jayant B. Udgaonkar
Born (1960-03-22) 22 March 1960 (age 64)
Maharashtra, India
NationalityIndian
Alma mater
Known forStudies on Protein folding
Awards1996 Birla Biology Award
2000 Shanti Swarup Bhatnagar Prize
2011 IITM Distinguished Alumnus Award
2011 CSIR G. N. Ramachandran Gold Medal
Scientific career
Fields
Institutions
Doctoral advisorGeorge P. Hess
Robert Lesh Baldwin

Jayant Bhalchandra Udgaonkar (born 1960) is an Indian biochemist, molecular biologist, and academic at the Indian Institute of Science Education and Research, Pune. He is the former Director of the Indian Institute of Science Education and Research, Pune,[1][2] and was previously a senior professor at the National Centre for Biological Sciences.[3] A J.C. Bose National Fellow, he is known for his studies on protein folding.[4] He is an elected fellow of the Indian Academy of Sciences,[5] Indian National Science Academy[6] and The World Academy of Sciences.[7] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2000, for his contributions to biological sciences.[8] He is the son of noted scientist Padmabhushan Bhalchandra Udgaonkar.[9]

Biography

Results of protein folding.

Jayant Udgaonkar, born on 22 March 1960 in the Indian state of Maharashtra, did his graduate studies in chemistry at St. Xavier's College, Mumbai during 1976–79 and secured his master's degree from the Indian Institute of Technology, Chennai in 1981.[10] Moving to Cornell University, he completed his doctoral studies under the guidance of George P. Hess to obtain a PhD for his thesis on acetylcholine receptor in 1986 after which did his post-doctoral studies under Robert Lesh Baldwin at Stanford University during 1986–89.[6] Returning to India, he joined National Centre for Biological Sciences of Tata Institute of Fundamental Research as a reader in 1990 and has been serving as a senior professor since 2007. In between, he held the positions of an associate professor (1995–98), Dean (1997–2008), Head of Administration (1997–2008), Head of Research (1997–2008), Head of Technical Services (1998–2000) and a professor (1998–2007) at the institute and served as an honorary faculty member at the Jawaharlal Nehru Centre for Advanced Scientific Research in 1999.[10] On 1 November 2017, he became the Director of the Indian Institute of Science Education and Research, Pune, succeeding Prof. Krishna N. Ganesh.[11]

Legacy

During his doctoral studies at Cornell University, Udgaonkar is known to have developed a protocol for rapid chemical kinetic studies at the cell surface.[6] Later, while pursuing his post-doctoral studies, he developed methodologies for hydrogen exchange using Nuclear magnetic resonance spectroscopy for exploring the intermediates populating protein folding pathways. Furthering his Stanford studies on protein folding at NCBS, he propounded the theory that initial hydrophobic collapse is the first stage in protein folding, which he demonstrated using a model protein barstar and elucidated the various transition stages of protein folding and unfolding.[12] He has also demonstrated that, contrary to the general understanding that a single dominant barrier slows down the protein folding, several distributed small barriers can also influence the reaction.[6] His current work focuses on formation of amyloid fibrils and his research has shown multiple pathways of aggregation in the formation of amyloid fibrils of different morphologies.[13]

Udgaonkar has published a number of articles in peer reviewed journals detailing his researches,[note 1] Google Scholar and ResearchGate, two online repositories of scientific articles, have listed several of them.[14][15] A former guest editor of the Current Opinion in Structural Biology of Elsevier (2013 and 2015) and a former editorial board member of Folding and Design (1996–98), he is an associate editor of the Biochemistry journal[10] and a member of the editorial board of Protein Engineering, Design and Selection (since 2003), an Oxford journal.[16] He is also a member of the Asia-Pacific International Molecular Biology Network since 2001 and has mentored several scholars in their doctoral researches.[6]

Awards and honors

Udgaonkar, who stood first in the BSc chemistry examinations of the University of Mumbai in 1979, received several scholarships and research fellowships including the National Merit Scholarship of the Government of India, Merit Scholarship of the Indian Institute of Technology, Madras, Jane Coffin Childs Memorial Fund for Medical Research fellowship, Biotechnology Career Fellowship of Rockefeller Foundation, Golden Jubilee Biotechnology fellowship of the Department of Biotechnology, Swarnajayanti fellowship of the Department of Science and Technology and Senior Research fellowship of Wellcome Trust and is a J. C. Bose National Fellow of the Department of Science and Technology, the tenancy of the fellowship running from 2007 till 2017.[10] He received the Birla Award in Biology in 1996 and the Indian Academy of Sciences elected him as a fellow in 1997.[5] The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 2000.[8] He became an elected fellow of the Indian National Science Academy in 2002 and The World Academy of Sciences elected him as a fellow in 2007.[7]Vigyan Shri Award under Rashtriya Vigyan Puraskar scheme (2024).

Selected bibliography

  • Sabareesan Ambadi Thody, Jayant B Udgaonkar (August 2016). "Pathogenic Mutations within the Disordered Palindromic Region of the Prion Protein Induce Structure Therein and Accelerate the Formation of Misfolded Oligomers". Journal of Molecular Biology. 428 (20): 3935–3947. doi:10.1016/j.jmb.2016.08.015. PMID 27545411.
  • Pooja Malhotra, Jayant B Udgaonkar (August 2016). "How cooperative are protein folding and unfolding transitions?: Cooperativity in protein folding/unfolding reactions". Protein Science. 25 (11): 1924–1941. doi:10.1002/pro.3015. PMC 5079258. PMID 27522064.
  • Rama Reddy Goluguri, Jayant B Udgaonkar (June 2016). "Microsecond Rearrangements of Hydrophobic Clusters in an Initially Collapsed Globule Prime Structure Formation during the Folding of a Small Protein". Journal of Molecular Biology. 428 (15): 3102–3117. doi:10.1016/j.jmb.2016.06.015. PMID 27370109.
  • Singh, Jogender; Kumar, Harish; Sabareesan, Ambadi T.; Udgaonkar, Jayant B. (3 December 2014). "Rational Stabilization of Helix 2 of the Prion Protein Prevents Its Misfolding and Oligomerization". Journal of the American Chemical Society. 136 (48): 16704–16707. doi:10.1021/ja510964t. ISSN 0002-7863. PMID 25407394.
  • Zaidi, Faisal N.; Nath, Utpal; Udgaonkar, Jayant B. (December 1997). "Multiple intermediates and transition states during protein unfolding". Nature Structural Biology. 4 (12): 1016–1024. doi:10.1038/nsb1297-1016. ISSN 1072-8368. PMID 9406552. S2CID 1692527.
  • Vishwas R Agashe, Jayant B Udgaonkar (March 1995). "Thermodynamics of denaturation of barstar: evidence for cold denaturation and evaluation of the interaction with guanidine hydrochloride". Biochemistry. 34 (10): 3286–99. doi:10.1021/bi00010a019. PMID 7880824.
  • Ritu Khurana, Jayant B Udgaonkar (January 1994). "Equilibrium unfolding studies of barstar: evidence for an alternative conformation which resembles a molten globule". Biochemistry. 33 (1): 106–115. doi:10.1021/bi00167a014. PMID 8286327.
  • Jayant B Udgaonkar, Robert L Baldwin (November 1990). "Early folding intermediate of ribonuclease A." Proceedings of the National Academy of Sciences. 87 (21): 8197–8201. Bibcode:1990PNAS...87.8197U. doi:10.1073/pnas.87.21.8197. PMC 54922. PMID 2236032.

See also

Notes

  1. ^ Please see Selected bibliography section

References

  1. ^ Nair, Ardhra. "New IISER director points at lack of funding for research". The Times of India. Retrieved 1 November 2017.
  2. ^ "Government clears appointment of top officials of four IIMs, IISER". Hindustan Times. 19 September 2017.
  3. ^ "Prof. Jayant B. Udgaonkar on NCBS". National Centre for Biological Sciences. 2016. Retrieved 15 October 2016.
  4. ^ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  5. ^ a b "Fellow profile - Udgaonkar". Indian Academy of Sciences. 2016. Retrieved 6 October 2016.
  6. ^ a b c d e "Indian fellow - Udgaonkar". Indian National Science Academy. 2016. Retrieved 11 October 2016.
  7. ^ a b "TWAS fellow". TWAS. 2016. Retrieved 15 October 2016.
  8. ^ a b "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  9. ^ Phondke, Bal; Sheth, Parul R.; Naik-Satam, Suhas; Deshpande, A.P. (2007). B.M. Udgaonkar: Eminent Scientist and Educationist (PDF). Mumbai: National Center for Science Communication; Homi Bhabha Centre for Science Communication.
  10. ^ a b c d "Profile on NCBS" (PDF). National Centre for Biological Sciences. 2016. Retrieved 15 October 2016.
  11. ^ "Director". IISER Pune. Retrieved 1 November 2017.
  12. ^ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Archived from the original (PDF) on 4 March 2016. Retrieved 5 October 2016.
  13. ^ "Summary of Achievements" (PDF). SERB. 2016. Retrieved 16 October 2016.
  14. ^ "Jayant Udgaonkar on Google Scholar". Author profile. Google Scholar. 2016. Retrieved 16 October 2016.
  15. ^ "Jayant Udgaonkar on ResearchGate". Author profile. 2016. Retrieved 16 October 2016.
  16. ^ "Editorial Office". Oxford Journals. 2016. Archived from the original on 21 March 2016. Retrieved 16 October 2016.
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