Nebulette: Difference between revisions
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'''Nebulette''' is an isoform of the protein [[nebulin]]. While nebulin (600-900 kDa) is expressed preferentially in [[skeletal muscle]], nebulette (107 kDa) is expressed in [[cardiac muscle]]. Nebulette was identified in 1995 by Mocman and Wang using primary cultures of chicken embryonic [[cardiomyocyte]]s by [[immunoprecipitation]]s with certain anti-nebulin [[monoclonal antibodies]].<ref name="moncman">{{cite journal |author=Moncman & Wang |title=Nebulette: a 107 kD nebulin-like protein in cardiac muscle |journal=Cell Motil Cytoskeleton |volume=32 |issue=3 |pages=205-25 |year=1995 |pmid=8581976 }}</ref> |
'''Nebulette''' is an isoform of the protein [[nebulin]]. While nebulin (600-900 kDa) is expressed preferentially in [[skeletal muscle]], nebulette (107 kDa) is expressed in [[cardiac muscle]]. Nebulette was identified in 1995 by Mocman and Wang using primary cultures of chicken embryonic [[cardiomyocyte]]s by [[immunoprecipitation]]s with certain anti-nebulin [[monoclonal antibodies]].<ref name="moncman">{{cite journal |author=Moncman & Wang |title=Nebulette: a 107 kD nebulin-like protein in cardiac muscle |journal=Cell Motil Cytoskeleton |volume=32 |issue=3 |pages=205-25 |year=1995 |pmid=8581976 }}</ref> Normal expression of nebulette is essential for the assembly and [[muscle contraction|contractile function]] of [[myofibril]]s.<ref name="moncman2">{{cite journal |author=Moncman & Wang |title=Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function |journal=Exp Cell Res |volume=273 |issue=2 |pages=204-18 |year=2002 |pmid=11822876 }}</ref> |
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==References== |
==References== |
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Revision as of 22:04, 14 July 2007
| nebulette | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NEBL | ||||||
| NCBI gene | 10529 | ||||||
| HGNC | 16932 | ||||||
| OMIM | 605491 | ||||||
| RefSeq | NM_006393 | ||||||
| UniProt | O76041 | ||||||
| Other data | |||||||
| Locus | Chr. 10 p12 | ||||||
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Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle. Nebulette was identified in 1995 by Mocman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies.[1] Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.[2]
References
- ^ Moncman & Wang (1995). "Nebulette: a 107 kD nebulin-like protein in cardiac muscle". Cell Motil Cytoskeleton. 32 (3): 205–25. PMID 8581976.
- ^ Moncman & Wang (2002). "Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function". Exp Cell Res. 273 (2): 204–18. PMID 11822876.
External links
- nebulette at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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