Calcium-sensing receptor: Difference between revisions
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The '''calcium-sensing receptor''' is a [[G-protein coupled receptor]] which senses extracellular levels of [[calcium]] ion. In the [[parathyroid gland]], the calcium-sensing receptor controls calcium [[homeostasis]] by regulating the release of [[parathyroid hormone]].<ref name="pmid17117288">{{cite journal | author = D'Souza-Li L | title = The calcium-sensing receptor and related diseases | journal = Arquivos brasileiros de endocrinologia e metabologia | volume = 50 | issue = 4 | pages = 628-39 | year = 2006 | pmid = 17117288 | doi = | issn = | url = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000400008&nrm=iso }}</ref> |
The '''calcium-sensing receptor''' is a [[G-protein coupled receptor]] which senses extracellular levels of [[calcium]] ion. In the [[parathyroid gland]], the calcium-sensing receptor controls calcium [[homeostasis]] by regulating the release of [[parathyroid hormone]].<ref name="pmid17117288">{{cite journal | author = D'Souza-Li L | title = The calcium-sensing receptor and related diseases | journal = Arquivos brasileiros de endocrinologia e metabologia | volume = 50 | issue = 4 | pages = 628-39 | year = 2006 | pmid = 17117288 | doi = | issn = | url = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000400008&nrm=iso }}</ref> |
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The drug [[cinacalcet]] is an [[allosteric]] modifier of the calcium-sensing receptor.<ref name="pmid16825031">{{cite journal | author = Torres PU | title = Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism caused by chronic kidney disease | journal = Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation | volume = 16 | issue = 3 | pages = 253-8 | year = 2006 | pmid = 16825031 | doi = 10.1053/j.jrn.2006.04.010 | issn = }}</ref> |
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==References== |
==References== |
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Revision as of 06:32, 12 September 2007
| calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CASR | ||||||
| Alt. symbols | HHC, HHC1 | ||||||
| NCBI gene | 846 | ||||||
| HGNC | 1514 | ||||||
| OMIM | 601199 | ||||||
| RefSeq | NM_000388 | ||||||
| UniProt | P41180 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q21.1 | ||||||
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The calcium-sensing receptor is a G-protein coupled receptor which senses extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone.[1]
The drug cinacalcet is an allosteric modifier of the calcium-sensing receptor.[2]
References
- ^ D'Souza-Li L (2006). "The calcium-sensing receptor and related diseases". Arquivos brasileiros de endocrinologia e metabologia. 50 (4): 628–39. PMID 17117288.
- ^ Torres PU (2006). "Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism caused by chronic kidney disease". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 16 (3): 253–8. doi:10.1053/j.jrn.2006.04.010. PMID 16825031.
External links
- Receptors,+Calcium-Sensing at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- CASR+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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