Tissue inhibitor of metalloproteinase: Difference between revisions

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The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitor of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.

Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.

The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.

The role of the pro-MMP-9/TIMP-1 complex is still unknown.

External links

Tissue+Inhibitor+of+Metalloproteinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Brew K, Dinakarpandian D, Nagase H (2000). "Tissue inhibitors of metalloproteinases: evolution, structure and function". Biochim Biophys Acta. 1477 (1–2): 267–83. PMID 10708863.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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-The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue inhibitor of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: {{Gene|TIMP1}}, {{Gene|TIMP2}}, {{Gene|TIMP3}} and {{Gene|TIMP4}}.
+The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue inhibitor of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: ''[[TIMP1]]'', {{Gene|TIMP2}}, {{Gene|TIMP3}} and {{Gene|TIMP4}}.
-Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.
+Overall, all [[Matrix metalloproteinase|MMP]]s are inhibited by TIMPs once they are activated but the [[gelatinase]]s ([[MMP2|MMP-2]] and [[MMP9|MMP-9]]) can form complexes with TIMPs when the enzymes are in the latent form.
-The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.
+The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP ([[MMP14|MMP-14]]), a membrane-anchored MMP.
 The role of the pro-MMP-9/TIMP-1 complex is still unknown.