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==Controversy over structure of tRNA==
==Controversy over structure of tRNA==
{{Main|tRNA #History|l1=tRNA history}}
{{Main|tRNA #History|l1=tRNA history}}
Therer had been some intense competition among several groups worldwide for solving the 3D structure of tRNA during sixties and early seventies. Final round of that was between MIT's [[Alexander Rich|Rich]] group and [[Aaron Klug]]'s group at Cambridge. Dr. Kim first published 4Å structure in ''[[Science (journal)|Science]]'' in 1973.<ref name="seventhree"/> Next year his group came up with 3Å structure.<ref>{{cite journal |author=Suddath FL, Quigley GJ, McPherson A, ''et al'' |title=Three-dimensional structure of yeast phenylalanine transfer RNA at 3.0angstroms resolution |journal=Nature |volume=248 |issue=443 |pages=20–4 |year=1974 |pmid=4594440 |doi=}}</ref> But from Klug group's argument,<ref>[http://www.ias.ac.in/jbiosci/oct2006/453.pdf B F C Brown's reminiscence on the tRNA structure]</ref> after a symposium held in June 1974, where Kim's group arguably heard the different results of Klug's experiment, they rewritten and published revised paper on 3Å structure within a month in ''Science'',<ref>{{cite journal |author=Kim SH, Suddath FL, Quigley GJ, ''et al'' |title=Three-dimensional tertiary structure of yeast phenylalanine transfer RNA |journal=Science |volume=185 |issue=149 |pages=435–40 |year=1974 |pmid=4601792 |doi=}}</ref> which was two weeks before Klug's publishment in ''[[Nature (journal)|Nature]]'' on 3Å structure.<ref>{{cite journal |author=Robertus JD, Ladner JE, Finch JT, ''et al'' |title=Structure of yeast phenylalanine tRNA at 3 A resolution |journal=Nature |volume=250 |issue=467 |pages=546–51 |year=1974 |pmid=4602655 |doi=}}</ref> Klug complained to [[Francis Crick]], who wrote the letters to A. Rich concerning the accusations.<ref>[http://profiles.nlm.nih.gov/SC/B/B/X/Y/_/scbbxy.pdf Crick's first letter to A. Rich on the accusation]</ref> However, Rich denied the scientific misconduct.<ref>[http://profiles.nlm.nih.gov/SC/B/B/P/P/_/scbbpp.pdf Rich's reply to Crick's first letter, Aug 1974]</ref>
Therer had been some intense competition among several groups worldwide for solving the 3D structure of tRNA during sixties and early seventies. Final round of that was between MIT's [[Alexander Rich|Rich]] group and [[Aaron Klug]]'s group at Cambridge. Dr. Kim first published 4Å structure in ''[[Science (journal)|Science]]'' in 1973.<ref name="seventhree"/> Next year his group came up with 3Å structure.<ref>{{cite journal |author=Suddath FL, Quigley GJ, McPherson A, ''et al'' |title=Three-dimensional structure of yeast phenylalanine transfer RNA at 3.0angstroms resolution |journal=Nature |volume=248 |issue=443 |pages=20–4 |year=1974 |pmid=4594440 |doi=}}</ref> But from Klug group's argument,<ref>{{cite journal |author=Clark BF |title=The crystallization and structural determination of tRNA |journal=Trends Biochem. Sci. |volume=26 |issue=8 |pages=511–4 |year=2001 }} ''Brian FC Clark's reminiscence on the tRNA structure'' [http://www.ias.ac.in/jbiosci/oct2006/453.pdf pdf]</ref> after a symposium held in June 1974, where Kim's group arguably heard the different results of Klug's experiment, they rewritten and published revised paper on 3Å structure within a month in ''Science'',<ref>{{cite journal |author=Kim SH, Suddath FL, Quigley GJ, ''et al'' |title=Three-dimensional tertiary structure of yeast phenylalanine transfer RNA |journal=Science |volume=185 |issue=149 |pages=435–40 |year=1974 |pmid=4601792 |doi=}}</ref> which was two weeks before Klug's publishment in ''[[Nature (journal)|Nature]]'' on 3Å structure.<ref>{{cite journal |author=Robertus JD, Ladner JE, Finch JT, ''et al'' |title=Structure of yeast phenylalanine tRNA at 3 A resolution |journal=Nature |volume=250 |issue=467 |pages=546–51 |year=1974 |pmid=4602655 |doi=}}</ref> Klug complained to [[Francis Crick]], who wrote the letters to A. Rich concerning the accusations.<ref>[http://profiles.nlm.nih.gov/SC/B/B/X/Y/_/scbbxy.pdf Crick's first letter to A. Rich on the accusation]</ref> However, Rich denied the scientific misconduct.<ref>[http://profiles.nlm.nih.gov/SC/B/B/P/P/_/scbbpp.pdf Rich's reply to Crick's first letter, Aug 1974]</ref>


==Biographical information==
==Biographical information==

Revision as of 19:30, 28 November 2007

Kim Sung-Hou Ph.D. is a Korean-born American crystallographer and protein biophysicist. Dr. Kim reported first 3D structure of tRNA with A. Rich in 1973.[1] He also published many papers on the structures of protein molecules including Ras.[2] He is a member of U.S. National Academy of Science since 1994. He is currently a professor and a senior scientist at chemistry department of U.C. Berkeley and Lawrence Berkeley National Laboratory(LBL), respectively.

Controversy over structure of tRNA

Main article: tRNA history

Therer had been some intense competition among several groups worldwide for solving the 3D structure of tRNA during sixties and early seventies. Final round of that was between MIT's Rich group and Aaron Klug's group at Cambridge. Dr. Kim first published 4Å structure in Science in 1973.[1] Next year his group came up with 3Å structure.[3] But from Klug group's argument,[4] after a symposium held in June 1974, where Kim's group arguably heard the different results of Klug's experiment, they rewritten and published revised paper on 3Å structure within a month in Science,[5] which was two weeks before Klug's publishment in Nature on 3Å structure.[6] Klug complained to Francis Crick, who wrote the letters to A. Rich concerning the accusations.[7] However, Rich denied the scientific misconduct.[8]

Biographical information

  • Born 1937, South Korea
  • B.S.(1960), M.S.(1962) in chemistry, Seoul National University, South Korea
  • Ph.D(1966) University of Pittsburgh
  • Research Associate M.I.T. (1966-70) under A. Rich
  • Senior Research Scientist M.I.T. (1970-72) with A. Rich
  • Faculty of Biochemistry, Duke University School of Medicine (1972-78)
  • Professor, University of California, Berkeley (1978- )

References

  1. ^ a b Kim SH, Quigley GJ, Suddath FL; et al. (1973). "Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain". Science. 179 (70): 285–8. PMID 4566654. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  2. ^ de Vos AM, Tong L, Milburn MV; et al. (1988). "Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21". Science. 239 (4842): 888–93. PMID 2448879. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  3. ^ Suddath FL, Quigley GJ, McPherson A; et al. (1974). "Three-dimensional structure of yeast phenylalanine transfer RNA at 3.0angstroms resolution". Nature. 248 (443): 20–4. PMID 4594440. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  4. ^ Clark BF (2001). "The crystallization and structural determination of tRNA". Trends Biochem. Sci. 26 (8): 511–4. Brian FC Clark's reminiscence on the tRNA structure pdf
  5. ^ Kim SH, Suddath FL, Quigley GJ; et al. (1974). "Three-dimensional tertiary structure of yeast phenylalanine transfer RNA". Science. 185 (149): 435–40. PMID 4601792. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  6. ^ Robertus JD, Ladner JE, Finch JT; et al. (1974). "Structure of yeast phenylalanine tRNA at 3 A resolution". Nature. 250 (467): 546–51. PMID 4602655. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  7. ^ Crick's first letter to A. Rich on the accusation
  8. ^ Rich's reply to Crick's first letter, Aug 1974

Kim group webpage at Cal

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