GLUT2

solute carrier family 2 (facilitated glucose transporter), member 2
Identifiers
Symbol	SLC2A2
Alt. symbols	GLUT2
NCBI gene	6514
HGNC	11006
OMIM	138160
RefSeq	NM_000340
UniProt	P11168
Other data
Locus	Chr. 3 q26.2-q27
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GLUT 2 is a transmembrane carrier protein and gene which is involved in passive glucose transport, especially the renal glucose reabsorption.

Locations

It is found in cellular membranes of:

• liver
• pancreatic beta cells
• hypothalamus
• basolateral membrane of small intestine
• basolateral membrane of renal tubular cells

Function

It has high capacity but low affinity (high Km, ca. 5 mM) part of "the glucose sensor" in pancreatic β-cells. It is a very efficient carrier for glucose. This receptor is insulin-independent.

It may also carry glucosamine, suspected because mouse embryos lacking this glucose carrier protein/gene- and its suspected capacity to transport glucosamine- soon die. According to genetics researchers in neonatal and maternal-fetal medicine at Harvard University Medical School and Beth-Israel Deaconess Hospital Medical Center, this creates a problem for diabetic pregnancies in which glucose levels in the woman are uncontrolled, exposing her fetus to the possibility of neural tube and cardiac defects in the early-developing brain, spine, and heart.

See also

• Glucose transporter

External links

• MeSH entry: Glucose Transporter Type 2