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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->_nl_{{PBB_Controls_nl_| update_page = yes _nl_| require_manual_inspection = no _nl_| update_protein_box = yes_nl_| update_summary = no_nl_| update_citations = yes_nl_}}_nl__nl_<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->_nl_{{GNF_Protein_box_nl_ | image = PBB_Protein_CD209_image.jpg_nl_ | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k9i._nl_ | PDB = {{PDB2|1k9i}}, {{PDB2|1sl4}}, {{PDB2|1sl5}}, {{PDB2|2b6b}}, {{PDB2|2it5}}, {{PDB2|2it6}}_nl_ | Name = CD209 molecule_nl_ | HGNCid = 1641_nl_ | Symbol = CD209_nl_ | AltSymbols =; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; MGC129965_nl_ | OMIM = 604672_nl_ | ECnumber = _nl_ | Homologene = 64372_nl_ | MGIid = 2157942_nl_ | GeneAtlas_image1 = PBB_GE_CD209_207277_at_tn.png_nl_ | GeneAtlas_image2 = PBB_GE_CD209_207278_s_at_tn.png_nl_ | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005537 |text = mannose binding}} {{GNF_GO|id=GO:0042607 |text = exogenous peptide antigen binding}} {{GNF_GO|id=GO:0046790 |text = virion binding}} _nl_ | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} _nl_ | Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007159 |text = leukocyte adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0009988 |text = cell-cell recognition}} {{GNF_GO|id=GO:0019048 |text = virus-host interaction}} {{GNF_GO|id=GO:0019062 |text = virion attachment to host cell surface receptor}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0046795 |text = intracellular virion transport}} {{GNF_GO|id=GO:0046800 |text = enhancement of virulence}} {{GNF_GO|id=GO:0046968 |text = peptide antigen transport}} _nl_ | Orthologs = {{GNF_Ortholog_box_nl_ | Hs_EntrezGene = 30835_nl_ | Hs_Ensembl = ENSG00000090659_nl_ | Hs_RefseqProtein = NP_066978_nl_ | Hs_RefseqmRNA = NM_021155_nl_ | Hs_GenLoc_db = _nl_ | Hs_GenLoc_chr = 19_nl_ | Hs_GenLoc_start = 7710882_nl_ | Hs_GenLoc_end = 7718406_nl_ | Hs_Uniprot = Q9NNX6_nl_ | Mm_EntrezGene = 170786_nl_ | Mm_Ensembl = ENSMUSG00000031494_nl_ | Mm_RefseqmRNA = NM_133238_nl_ | Mm_RefseqProtein = NP_573501_nl_ | Mm_GenLoc_db = _nl_ | Mm_GenLoc_chr = 8_nl_ | Mm_GenLoc_start = 3743395_nl_ | Mm_GenLoc_end = 3748984_nl_ | Mm_Uniprot = Q2TA59_nl_ }}_nl_}}_nl_'''DC-SIGN''' or '''[[Cluster of Differentiation|CD]]209''' is a C-type [[lectin]] receptor present on both [[macrophages]] and [[Dendritic cells]]._nl__nl_DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns [[PAMP]]s commonly found on viruses, bacteria and fungi. This binding interaction activates [[phagocytosis]].<ref>{{cite journal |author=McGreal E, Miller J, Gordon S |title=Ligand recognition by antigen-presenting cell C-type lectin receptors |journal=Curr Opin Immunol |volume=17 |issue=1 |pages=18-24 |year=2005 |pmid=15653305}}</ref>_nl__nl_On myeloid and pre-plasmacytoid [[dendritic cell]]s DC-SIGN mediates dendritic cell rolling interactions with blood [[endothelium]] and activation of [[CD4]]+ [[T cell]]s, as well as recognition of [[pathogen]] haptens._nl__nl_==Role in HIV infection==_nl__nl_This [[molecule]] is involved in the initial stages of the [[HIV|Human Immunodeficiency Virus]] infection, as the HIV [[gp120]] molecule causes co-internalization of the DC-SIGN molecule and HIV virion. _nl__nl_The dendritic cell then migrates to the cognate lymphoid organ, whereupon recycling of the DC-SIGN/HIV virion complex to the cell periphery facilitates HIV infection of T cells by interaction between DC-SIGN and ICAM-3._nl__nl_==References==_nl_{{reflist}}_nl__nl_==Further reading==_nl_{{refbegin | 2}}_nl_{{PBB_Further_reading _nl_| citations = _nl_*{{cite journal | author=Geijtenbeek TB, Engering A, Van Kooyk Y |title=DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. |journal=J. Leukoc. Biol. |volume=71 |issue= 6 |pages= 921-31 |year= 2002 |pmid= 12050176 |doi= }}_nl_*{{cite journal | author=Baribaud F, Doms RW, Pöhlmann S |title=The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? |journal=Expert Opin. Ther. Targets |volume=6 |issue= 4 |pages= 423-31 |year= 2006 |pmid= 12223058 |doi= 10.1517/14728222.6.4.423 }}_nl_*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}_nl_*{{cite journal | author=van Kooyk Y, Geijtenbeek TB |title=DC-SIGN: escape mechanism for pathogens. |journal=Nat. Rev. Immunol. |volume=3 |issue= 9 |pages= 697-709 |year= 2003 |pmid= 12949494 |doi= 10.1038/nri1182 }}_nl_*{{cite journal | author=Turville S, Wilkinson J, Cameron P, ''et al.'' |title=The role of dendritic cell C-type lectin receptors in HIV pathogenesis. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 710-8 |year= 2004 |pmid= 12960229 |doi= 10.1189/jlb.0503208 }}_nl_*{{cite journal | author=Cambi A, Figdor CG |title=Dual function of C-type lectin-like receptors in the immune system. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 5 |pages= 539-46 |year= 2004 |pmid= 14519388 |doi= }}_nl_*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}_nl_*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}_nl_}}_nl_{{refend}}_nl__nl_==External links==_nl_* {{MeshName|DC-SIGN}}_nl__nl_[[Category:Receptors]]_nl_[[category:Clusters of differentiation]]_nl__nl__nl_{{Clusters of differentiation}}_nl_{{protein-stub}}_nl_
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD209_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k9i.
| PDB = {{PDB2|1k9i}}, {{PDB2|1sl4}}, {{PDB2|1sl5}}, {{PDB2|2b6b}}, {{PDB2|2it5}}, {{PDB2|2it6}}
| Name = CD209 molecule
| HGNCid = 1641
| Symbol = CD209
| AltSymbols =; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; MGC129965
| OMIM = 604672
| ECnumber =
| Homologene = 64372
| MGIid = 2157942
| GeneAtlas_image1 = PBB_GE_CD209_207277_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD209_207278_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005537 |text = mannose binding}} {{GNF_GO|id=GO:0042607 |text = exogenous peptide antigen binding}} {{GNF_GO|id=GO:0046790 |text = virion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007159 |text = leukocyte adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0009988 |text = cell-cell recognition}} {{GNF_GO|id=GO:0019048 |text = virus-host interaction}} {{GNF_GO|id=GO:0019062 |text = virion attachment to host cell surface receptor}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0046795 |text = intracellular virion transport}} {{GNF_GO|id=GO:0046800 |text = enhancement of virulence}} {{GNF_GO|id=GO:0046968 |text = peptide antigen transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 30835
| Hs_Ensembl = ENSG00000090659
| Hs_RefseqProtein = NP_066978
| Hs_RefseqmRNA = NM_021155
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 7710882
| Hs_GenLoc_end = 7718406
| Hs_Uniprot = Q9NNX6
| Mm_EntrezGene = 170786
| Mm_Ensembl = ENSMUSG00000031494
| Mm_RefseqmRNA = NM_133238
| Mm_RefseqProtein = NP_573501
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 3743395
| Mm_GenLoc_end = 3748984
| Mm_Uniprot = Q2TA59
}}
}}
'''DC-SIGN''' or '''[[Cluster of Differentiation|CD]]209''' is a C-type [[lectin]] receptor present on both [[macrophages]] and [[Dendritic cells]].

DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns [[PAMP]]s commonly found on viruses, bacteria and fungi. This binding interaction activates [[phagocytosis]].<ref>{{cite journal |author=McGreal E, Miller J, Gordon S |title=Ligand recognition by antigen-presenting cell C-type lectin receptors |journal=Curr Opin Immunol |volume=17 |issue=1 |pages=18-24 |year=2005 |pmid=15653305}}</ref>

On myeloid and pre-plasmacytoid [[dendritic cell]]s DC-SIGN mediates dendritic cell rolling interactions with blood [[endothelium]] and activation of [[CD4]]+ [[T cell]]s, as well as recognition of [[pathogen]] haptens.

==Role in HIV infection==

This [[molecule]] is involved in the initial stages of the [[HIV|Human Immunodeficiency Virus]] infection, as the HIV [[gp120]] molecule causes co-internalization of the DC-SIGN molecule and HIV virion.

The dendritic cell then migrates to the cognate lymphoid organ, whereupon recycling of the DC-SIGN/HIV virion complex to the cell periphery facilitates HIV infection of T cells by interaction between DC-SIGN and ICAM-3.

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Geijtenbeek TB, Engering A, Van Kooyk Y |title=DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. |journal=J. Leukoc. Biol. |volume=71 |issue= 6 |pages= 921-31 |year= 2002 |pmid= 12050176 |doi= }}
*{{cite journal | author=Baribaud F, Doms RW, Pöhlmann S |title=The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? |journal=Expert Opin. Ther. Targets |volume=6 |issue= 4 |pages= 423-31 |year= 2006 |pmid= 12223058 |doi= 10.1517/14728222.6.4.423 }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=van Kooyk Y, Geijtenbeek TB |title=DC-SIGN: escape mechanism for pathogens. |journal=Nat. Rev. Immunol. |volume=3 |issue= 9 |pages= 697-709 |year= 2003 |pmid= 12949494 |doi= 10.1038/nri1182 }}
*{{cite journal | author=Turville S, Wilkinson J, Cameron P, ''et al.'' |title=The role of dendritic cell C-type lectin receptors in HIV pathogenesis. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 710-8 |year= 2004 |pmid= 12960229 |doi= 10.1189/jlb.0503208 }}
*{{cite journal | author=Cambi A, Figdor CG |title=Dual function of C-type lectin-like receptors in the immune system. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 5 |pages= 539-46 |year= 2004 |pmid= 14519388 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}

==External links==
* {{MeshName|DC-SIGN}}

[[Category:Receptors]]
[[category:Clusters of differentiation]]


{{Clusters of differentiation}}
{{protein-stub}}

Revision as of 01:17, 4 March 2008

_nl_Template:PBB Controls nl_nl__nl__nl_Template:GNF Protein box nl_nl_DC-SIGN or CD209 is a C-type lectin receptor present on both macrophages and Dendritic cells._nl__nl_DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis.[1]_nl__nl_On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens._nl__nl_==Role in HIV infection==_nl__nl_This molecule is involved in the initial stages of the Human Immunodeficiency Virus infection, as the HIV gp120 molecule causes co-internalization of the DC-SIGN molecule and HIV virion. _nl__nl_The dendritic cell then migrates to the cognate lymphoid organ, whereupon recycling of the DC-SIGN/HIV virion complex to the cell periphery facilitates HIV infection of T cells by interaction between DC-SIGN and ICAM-3._nl__nl_==References==_nl_

  1. ^ McGreal E, Miller J, Gordon S (2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Curr Opin Immunol. 17 (1): 18–24. PMID 15653305.{{cite journal}}: CS1 maint: multiple names: authors list (link)

_nl__nl_==Further reading==_nl_

_nl_Template:PBB Further reading nl_nl_

_nl__nl_==External links==_nl_* DC-SIGN at the U.S. National Library of Medicine Medical Subject Headings (MeSH)_nl__nl__nl__nl__nl__nl_

_nl_

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