Poly(A)-binding protein: Difference between revisions

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Poly(A) RNA Binding Protein PABP, PDB 1CVJ

Poly(A)-binding protein is a RNA-binding protein which binds to the poly(A) tail of mRNA. The poly(A) tail is located on the 3' end of mRNA. In the cytoplasm of eukaryotes Poly(A) binding protein binds to the intiation factor eIF-4G. EIF-4G is bound to eIF-4E, another initiation factor bound to the 5' cap on the 5' end of mRNA. This binding forms the characteristic loop structure of eukaryotic protein synthesis.

Genes

PABPC1, PABPC3, PABPC4, PABPC5

External links

Poly(A)-Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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+[[Image:RABP.PNG|thumb|right|300px|Poly(A) RNA Binding Protein PABP, PDB 1CVJ]]
-'''Poly(A)-binding protein''' is a [[RNA-binding protein]] which binds to the [[poly(A) tail]].
+'''Poly(A)-binding protein''' is a [[RNA-binding protein]] which binds to the [[poly(A) tail]] of mRNA.  The poly(A) tail is located on the 3' end of mRNA.  In the cytoplasm of eukaryotes Poly(A) binding protein binds to the intiation factor [[eIF-4G]].  EIF-4G is bound to [[eIF-4E]], another initiation factor bound to the [[5' cap]] on the 5' end of mRNA.  This binding forms the characteristic loop structure of eukaryotic protein synthesis.
 ==Genes==