CAMP receptor protein: Difference between revisions
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'''cAMP receptor protein''' (in short '''CRP''', also known as '''catabolite gene activator protein''' (in short '''CAP''')) is a [[regulatory protein]] in [[bacteria]]. This [[protein]] binds [[Cyclic adenosine monophosphate|cAMP]], which causes a conformational change that allows the protein to bind to tightly to a specific DNA sequence in the [[promoter]]s of the genes it controls. |
'''cAMP receptor protein''' (in short '''CRP''', also known as '''catabolite gene activator protein''' (in short '''CAP''')) is a [[regulatory protein]] in [[bacteria]]. This [[protein]] binds [[Cyclic adenosine monophosphate|cAMP]], which causes a conformational change that allows the protein to bind to tightly to a specific DNA sequence in the [[promoter]]s of the genes it controls.<ref>{{cite journal |author=Harman JG |title=Allosteric regulation of the cAMP receptor protein |journal=Biochim. Biophys. Acta |volume=1547 |issue=1 |pages=1–17 |year=2001 |pmid=11343786}}</ref> The genes regulated by this protein are mostly involved in energy metabolism, such as [[galactose]], [[citrate]], or the [[PEP group translocation]] reaction.<ref>{{cite journal |author=Weickert MJ, Adhya S |title=The galactose regulon of Escherichia coli |journal=Mol. Microbiol. |volume=10 |issue=2 |pages=245–51 |year=1993 |pmid=7934815}}</ref><ref>{{cite journal |author=Bott M |title=Anaerobic citrate metabolism and its regulation in enterobacteria |journal=Arch. Microbiol. |volume=167 |issue=2-3 |pages=78–88 |year=1997 |pmid=9133329}}</ref> |
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==References== |
==References== |
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Revision as of 22:12, 12 May 2008
 | It has been suggested that this article be merged into Catabolite_activator_protein and Talk:Catabolite_activator_protein#Merger proposal. (Discuss) Proposed since December 2007. |
| CAMP receptor protein | |||||||
|---|---|---|---|---|---|---|---|
 Structure of the E. coli Cyclic AMP Receptor Protein. | |||||||
| Identifiers | |||||||
| Symbol | CRP | ||||||
| Alt. symbols | CAP | ||||||
| NCBI gene | 289905 | ||||||
| PDB | 1I5Z | ||||||
| RefSeq | NP_289905 | ||||||
| UniProt | P0ACK0 | ||||||
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cAMP receptor protein (in short CRP, also known as catabolite gene activator protein (in short CAP)) is a regulatory protein in bacteria. This protein binds cAMP, which causes a conformational change that allows the protein to bind to tightly to a specific DNA sequence in the promoters of the genes it controls.[1] The genes regulated by this protein are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation reaction.[2][3]
References
- ^ Harman JG (2001). "Allosteric regulation of the cAMP receptor protein". Biochim. Biophys. Acta. 1547 (1): 1–17. PMID 11343786.
- ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. PMID 7934815.
- ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. PMID 9133329.
External links
crystal structure of CRP and binding site properties
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