Bradykinin receptor B2: Difference between revisions

BDKRB2
Identifiers
Aliases	BDKRB2, B2R, BK-2, BK2, BKR2, BRB2, bradykinin receptor B2
External IDs	OMIM: 113503; MGI: 102845; HomoloGene: 519; GeneCards: BDKRB2; OMA:BDKRB2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	96,244,166 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	105,561,496 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; mucosa of urinary bladder; ; pancreatic ductal cell; ; tendon of biceps brachii; ; gums; ; cartilage tissue; ; gingival epithelium; ; gallbladder; ; ectocervix; ; canal of the cervix;
	Top expressed in
	esophagus; ; embryo; ; embryo; ; adrenal gland; ; pituitary gland; ; lip; ; duodenum; ; placenta; ; muscle of thigh; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; type 1 angiotensin receptor binding; signal transducer activity; protease binding; protein binding; protein heterodimerization activity; phosphatidylinositol phospholipase C activity; bradykinin receptor activity;
Cellular component	integral component of membrane; endosome; membrane; integral component of plasma membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; response to salt stress; vasoconstriction; transmembrane receptor protein tyrosine kinase signaling pathway; response to stress; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; vasodilation; blood circulation; cell surface receptor signaling pathway; regulation of vascular permeability; regulation of vasoconstriction; negative regulation of peptidyl-serine phosphorylation; inflammatory response; arachidonic acid secretion; signal transduction; smooth muscle contraction; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	624
	12062
	ENSG00000168398
	ENSMUSG00000021070
	P30411
	P32299
	NM_000623; NM_001379692
	NM_009747
	NP_000614; NP_001366621
	NP_033877
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 20:03, 9 June 2008

Template:PBB Controls

Bradykinin receptor B2, also known as BDKRB2, is a bradykinin receptor, but also denotes the human gene encoding it.

Mechanism

The B2 receptor is a G protein-coupled receptor, probably coupled to G_q and G_i. G_q stimulates phospholipase C to increase intracellular free calcium and G_i inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.^[5]

Kallidin also signals through the B2 receptor.

Function

The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.

Gene

Alternate start codons result in two isoforms of the protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021070 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). "Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo". Hypertension. 37 (2 Part 2): 703–9. PMID 11230360.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "Entrez Gene: BDKRB2 bradykinin receptor B2".

@@ Line 71: / Line 71: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Duchêne J, Schanstra J, Cellier E, ''et al.'' |title=[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39-41 |year= 2002 |pmid= 11908480 |doi=  }}
+*{{cite journal  | author=Duchêne J, Schanstra J, Cellier E, ''et al.'' |title=[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39–41 |year= 2002 |pmid= 11908480 |doi=  }}
-*{{cite journal  | author=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48-56 |year= 2007 |pmid= 17569300 |doi=  }}
+*{{cite journal  | author=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48–56 |year= 2007 |pmid= 17569300 |doi=  }}
-*{{cite journal  | author=Hess JF, Borkowski JA, Young GS, ''et al.'' |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260-8 |year= 1992 |pmid= 1314587 |doi=  }}
+*{{cite journal  | author=Hess JF, Borkowski JA, Young GS, ''et al.'' |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260–8 |year= 1992 |pmid= 1314587 |doi=  }}
-*{{cite journal  | author=Eggerickx D, Raspe E, Bertrand D, ''et al.'' |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306-13 |year= 1992 |pmid= 1329734 |doi=  }}
+*{{cite journal  | author=Eggerickx D, Raspe E, Bertrand D, ''et al.'' |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306–13 |year= 1992 |pmid= 1329734 |doi=  }}
-*{{cite journal  | author=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226-33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800 }}
+*{{cite journal  | author=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226–33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800 }}
-*{{cite journal  | author=Braun A, Kammerer S, Böhme E, ''et al.'' |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234-40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801 }}
+*{{cite journal  | author=Braun A, Kammerer S, Böhme E, ''et al.'' |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234–40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801 }}
-*{{cite journal  | author=Ma JX, Wang DZ, Ward DC, ''et al.'' |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362-9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512 }}
+*{{cite journal  | author=Ma JX, Wang DZ, Ward DC, ''et al.'' |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362–9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512 }}
-*{{cite journal  | author=Powell SJ, Slynn G, Thomas C, ''et al.'' |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435-8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084 }}
+*{{cite journal  | author=Powell SJ, Slynn G, Thomas C, ''et al.'' |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435–8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084 }}
-*{{cite journal  | author=Menke JG, Borkowski JA, Bierilo KK, ''et al.'' |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583-6 |year= 1994 |pmid= 8063797 |doi=  }}
+*{{cite journal  | author=Menke JG, Borkowski JA, Bierilo KK, ''et al.'' |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=  }}
-*{{cite journal  | author=Hess JF, Borkowski JA, Macneil T, ''et al.'' |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1-8 |year= 1994 |pmid= 8302267 |doi=  }}
+*{{cite journal  | author=Hess JF, Borkowski JA, Macneil T, ''et al.'' |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1–8 |year= 1994 |pmid= 8302267 |doi=  }}
-*{{cite journal  | author=McIntyre P, Phillips E, Skidmore E, ''et al.'' |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346-55 |year= 1993 |pmid= 8394991 |doi=  }}
+*{{cite journal  | author=McIntyre P, Phillips E, Skidmore E, ''et al.'' |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346–55 |year= 1993 |pmid= 8394991 |doi=  }}
-*{{cite journal  | author=AbdAlla S, Godovac-Zimmermann J, Braun A, ''et al.'' |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514-9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060 }}
+*{{cite journal  | author=AbdAlla S, Godovac-Zimmermann J, Braun A, ''et al.'' |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514–9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060 }}
-*{{cite journal  | author=Isami S, Kishikawa H, Araki E, ''et al.'' |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412-20 |year= 1996 |pmid= 8777990 |doi=  }}
+*{{cite journal  | author=Isami S, Kishikawa H, Araki E, ''et al.'' |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412–20 |year= 1996 |pmid= 8777990 |doi=  }}
-*{{cite journal  | author=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236-44 |year= 1996 |pmid= 8900488 |doi=  }}
+*{{cite journal  | author=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236–44 |year= 1996 |pmid= 8900488 |doi=  }}
-*{{cite journal  | author=Soskic V, Nyakatura E, Roos M, ''et al.'' |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539-45 |year= 1999 |pmid= 10085087 |doi=  }}
+*{{cite journal  | author=Soskic V, Nyakatura E, Roos M, ''et al.'' |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539–45 |year= 1999 |pmid= 10085087 |doi=  }}
-*{{cite journal  | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239-44 |year= 1999 |pmid= 10188626 |doi=  }}
+*{{cite journal  | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=  }}
-*{{cite journal  | author=Efremov R, Truong MJ, Darcissac EC, ''et al.'' |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746-56 |year= 1999 |pmid= 10469138 |doi=  }}
+*{{cite journal  | author=Efremov R, Truong MJ, Darcissac EC, ''et al.'' |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746–56 |year= 1999 |pmid= 10469138 |doi=  }}
-*{{cite journal  | author=Marrero MB, Venema VJ, Ju H, ''et al.'' |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 Pt 2 |issue=  |pages= 335-40 |year= 1999 |pmid= 10510297 |doi=  }}
+*{{cite journal  | author=Marrero MB, Venema VJ, Ju H, ''et al.'' |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 Pt 2 |issue=  |pages= 335–40 |year= 1999 |pmid= 10510297 |doi=  }}
-*{{cite journal  | author=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658-73 |year= 2000 |pmid= 10653985 |doi=  }}
+*{{cite journal  | author=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658–73 |year= 2000 |pmid= 10653985 |doi=  }}
-*{{cite journal  | author=Golser R, Gorren AC, Leber A, ''et al.'' |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291-6 |year= 2000 |pmid= 10681501 |doi=  }}
+*{{cite journal  | author=Golser R, Gorren AC, Leber A, ''et al.'' |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291–6 |year= 2000 |pmid= 10681501 |doi=  }}
 }}
 {{refend}}