PPP2R5B: Difference between revisions

PPP2R5B
Identifiers
Aliases	PPP2R5B, B56B, PR61B, protein phosphatase 2 regulatory subunit B'beta, B56beta
External IDs	OMIM: 601644; MGI: 2388480; HomoloGene: 38157; GeneCards: PPP2R5B; OMA:PPP2R5B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,934,475 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,285,902 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; Pons; ; right frontal lobe; ; prefrontal cortex; ; cerebellar vermis; ; dorsal motor nucleus of vagus nerve; ; nucleus accumbens; ; lateral nuclear group of thalamus; ; cingulate gyrus;
	Top expressed in
	adrenal gland; ; Cerebellum; ; cerebellar cortex; ; olfactory bulb; ; striatum of neuraxis; ; superior frontal gyrus; ; Hypothalamus; ; primary visual cortex; ; bone marrow; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein phosphatase regulator activity; protein phosphatase activator activity;
Cellular component	cytosol; protein phosphatase type 2A complex; cytoplasm; nucleus;
Biological process	regulation of protein autophosphorylation; positive regulation of DNA-binding transcription factor activity; IRE1-mediated unfolded protein response; negative regulation of G0 to G1 transition; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of neuron projection development; positive regulation of protein-containing complex assembly; regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; signal transduction; regulation of signaling receptor activity; cellular response to growth factor stimulus; regulation of protein phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; regulation of phosphoprotein phosphatase activity; protein dephosphorylation; negative regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	5526
	225849
	ENSG00000068971
	ENSMUSG00000024777
	Q15173
	Q6PD28
	NM_006244
	NM_198168
	NP_006235
	NP_937811
	Wikidata
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Revision as of 22:46, 10 June 2008

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Protein phosphatase 2, regulatory subunit B', beta isoform, also known as PPP2R5B, is a human gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068971 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform".

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 | citations =
 *{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
-*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
+*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
-*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
+*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=  }}
-*{{cite journal  | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123-8 |year= 1995 |pmid= 7592815 |doi=  }}
+*{{cite journal  | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–8 |year= 1995 |pmid= 7592815 |doi=  }}
-*{{cite journal  | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236-44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
+*{{cite journal  | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
-*{{cite journal  | author=Zolnierowicz S, Van Hoof C, Andjelković N, ''et al.'' |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue=  |pages= 187-94 |year= 1996 |pmid= 8694763 |doi=  }}
+*{{cite journal  | author=Zolnierowicz S, Van Hoof C, Andjelković N, ''et al.'' |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue=  |pages= 187–94 |year= 1996 |pmid= 8694763 |doi=  }}
-*{{cite journal  | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081-9 |year= 1996 |pmid= 8703017 |doi=  }}
+*{{cite journal  | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081–9 |year= 1996 |pmid= 8703017 |doi=  }}
-*{{cite journal  | author=McCright B, Brothman AR, Virshup DM |title=Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. |journal=Genomics |volume=36 |issue= 1 |pages= 168-70 |year= 1997 |pmid= 8812429 |doi=  }}
+*{{cite journal  | author=McCright B, Brothman AR, Virshup DM |title=Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. |journal=Genomics |volume=36 |issue= 1 |pages= 168–70 |year= 1997 |pmid= 8812429 |doi=  }}
-*{{cite journal  | author=Tung HY, De Rocquigny H, Zhao LJ, ''et al.'' |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197-201 |year= 1997 |pmid= 9013886 |doi=  }}
+*{{cite journal  | author=Tung HY, De Rocquigny H, Zhao LJ, ''et al.'' |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=  }}
-*{{cite journal  | author=Forbes SA, Pannett AA, Bassett JH, ''et al.'' |title=Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |journal=Hum. Genet. |volume=100 |issue= 3-4 |pages= 481-5 |year= 1997 |pmid= 9272177 |doi=  }}
+*{{cite journal  | author=Forbes SA, Pannett AA, Bassett JH, ''et al.'' |title=Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |journal=Hum. Genet. |volume=100 |issue= 3-4 |pages= 481–5 |year= 1997 |pmid= 9272177 |doi=  }}
-*{{cite journal  | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432-43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
+*{{cite journal  | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
-*{{cite journal  | author=Ikeda S, Kishida M, Matsuura Y, ''et al.'' |title=GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. |journal=Oncogene |volume=19 |issue= 4 |pages= 537-45 |year= 2000 |pmid= 10698523 |doi= 10.1038/sj.onc.1203359 }}
+*{{cite journal  | author=Ikeda S, Kishida M, Matsuura Y, ''et al.'' |title=GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. |journal=Oncogene |volume=19 |issue= 4 |pages= 537–45 |year= 2000 |pmid= 10698523 |doi= 10.1038/sj.onc.1203359 }}
-*{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956-67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
+*{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
-*{{cite journal  | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
+*{{cite journal  | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
 *{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Galey D, Becker K, Haughey N, ''et al.'' |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358-71 |year= 2003 |pmid= 12775419 |doi=  }}
+*{{cite journal  | author=Galey D, Becker K, Haughey N, ''et al.'' |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Dozier C, Bonyadi M, Baricault L, ''et al.'' |title=Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. |journal=Biol. Cell |volume=96 |issue= 7 |pages= 509-17 |year= 2005 |pmid= 15380617 |doi= 10.1016/j.biolcel.2004.04.010 }}
+*{{cite journal  | author=Dozier C, Bonyadi M, Baricault L, ''et al.'' |title=Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. |journal=Biol. Cell |volume=96 |issue= 7 |pages= 509–17 |year= 2005 |pmid= 15380617 |doi= 10.1016/j.biolcel.2004.04.010 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 }}
 {{refend}}

Revision as of 22:46, 10 June 2008

References

Further reading