Bradykinin receptor B2: Difference between revisions
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'''Bradykinin receptor B2 |
'''Bradykinin receptor B2 (B<sub>2</sub>)''' is a [[g-protein coupled receptor]] for [[bradykinin]], encoded by the '''BDKRB2''' [[gene]] in humans. |
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==Mechanism== |
==Mechanism== |
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The |
The B<sub>2</sub> receptor is a [[G protein-coupled receptor]], probably coupled to [[Gq alpha subunit|G<sub>q</sub>]] and [[Gi alpha subunit|G<sub>i</sub>]]. G<sub>q</sub> stimulates [[phospholipase C]] to increase [[intracellular]] free [[calcium]] and G<sub>i</sub> inhibits [[adenylate cyclase]]. Furthermore, the receptor stimulates the [[mitogen-activated protein kinase]] pathways. It is ubiquitously and constitutively expressed in healthy tissues. |
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The |
The B<sub>2</sub> receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B<sub>2</sub> receptors.<ref name="pmid11230360">{{cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 }}</ref> |
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[[Kallidin]] also signals through the |
[[Kallidin]] also signals through the B<sub>2</sub> receptor. |
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==Function== |
==Function== |
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Revision as of 15:50, 12 December 2008
Template:PBB Bradykinin receptor B2 (B2) is a g-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.
Mechanism
The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.[1]
Kallidin also signals through the B2 receptor.
Function
The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.
Gene
Alternate start codons result in two isoforms of the protein.[2]
See also
References
- ^ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). "Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo". Hypertension. 37 (2 Part 2): 703–9. PMID 11230360.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: BDKRB2 bradykinin receptor B2".
External links
- "Bradykinin Receptors: B2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help)
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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