Janeway lesion: Difference between revisions
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'''Janeway lesions''' are non-[[tender]], small [[erythematous]] or [[haemorrhagic]] [[macule|macular]] or [[nodule|nodular]] lesions on the [[palms]] or [[Sole (foot)|soles]] only a few millimeters in diameter that are [[pathognomonic]] of [[endocarditis|infective endocarditis]].<ref name = "Farrior">{{cite journal | last = Farrior | first = J.B. | coauthors = Silverman M.E. | title = A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal = Chest. | volume = 70 | issue = 2 | pages = 239–43 | year = 1976 | pmid = 947688 | doi = 10.1378/chest.70.2.239}}</ref> Pathologically, the lesion is described to be a [[abscess|microabscess]] of the [[dermis]] with marked [[necrosis]] and inflammatory infiltrate not involving the [[epidermis(skin)|epidermis]], which is due to the deposition of circulating [[immune complexes]] in small blood vessels.<ref name = "Farrior"/> |
'''Janeway lesions''' are non-[[tender]], small [[erythematous]] or [[haemorrhagic]] [[macule|macular]] or [[nodule|nodular]] lesions on the [[palms]] or [[Sole (foot)|soles]] only a few millimeters in diameter that are [[pathognomonic]] of [[endocarditis|infective endocarditis]].<ref name = "Farrior">{{cite journal | last = Farrior | first = J.B. | coauthors = Silverman M.E. | title = A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal = Chest. | volume = 70 | issue = 2 | pages = 239–43 | year = 1976 | pmid = 947688 | doi = 10.1378/chest.70.2.239}}</ref> Pathologically, the lesion is described to be a [[abscess|microabscess]] of the [[dermis]] with marked [[necrosis]] and inflammatory infiltrate not involving the [[epidermis(skin)|epidermis]], which is due to the deposition of circulating [[immune complexes]] in small blood vessels.<ref name = "Farrior"/> |
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[[Osler's node]]s and Janeway lesions are similar, but Osler's nodes present with tenderness.<ref name="pmid947688">{{cite journal |author=Farrior JB, Silverman ME |title=A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal=Chest |volume=70 |issue=2 |pages=239–43 |year=1976 |month=August |pmid=947688 |doi= |url=http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=947688}}</ref> |
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==Eponym== |
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They are named after [[Edward G. Janeway]] (1841–1911), a [[professor]] of [[medicine]] with interests in [[cardiology]] and [[infectious disease]].<ref>{{cite journal |author=Janeway C. |title=Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response |journal=J. Immunol. |volume=161 |issue=2 |pages=539–44 |year=1998 |pmid=9670925}}</ref> |
They are named after [[Edward G. Janeway]] (1841–1911), a [[professor]] of [[medicine]] with interests in [[cardiology]] and [[infectious disease]].<ref>{{cite journal |author=Janeway C. |title=Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response |journal=J. Immunol. |volume=161 |issue=2 |pages=539–44 |year=1998 |pmid=9670925}}</ref> |
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==See also== |
==See also== |
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*[[Osler's node]]s |
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*[[Roth's spot]]s |
*[[Roth's spot]]s |
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==References== |
==References== |
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{{reflist}} |
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<references /> |
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{{Eponymous medical signs for circulatory and respiratory systems}} |
{{Eponymous medical signs for circulatory and respiratory systems}} |
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Revision as of 15:32, 20 December 2008
Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are pathognomonic of infective endocarditis.[1] Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis, which is due to the deposition of circulating immune complexes in small blood vessels.[1]
Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness.[2]
Eponym
They are named after Edward G. Janeway (1841–1911), a professor of medicine with interests in cardiology and infectious disease.[3]
See also
References
- ^ a b Farrior, J.B. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–43. doi:10.1378/chest.70.2.239. PMID 947688.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Farrior JB, Silverman ME (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–43. PMID 947688.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Janeway C. (1998). "Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response". J. Immunol. 161 (2): 539–44. PMID 9670925.
Template:Eponymous medical signs for circulatory and respiratory systems