Calcipotriol: Difference between revisions
corrected IUPAC name |
|||
| Line 1: | Line 1: | ||
{{Drugbox| |
{{Drugbox| |
||
| IUPAC_name = (1''R'',3''S'')-5- |
| IUPAC_name = (1''R'',3''S'',5''E'')-5-{2-[(1''R'',3a''S'',4''Z'',7a''R'')-1-[(2''R'',3''E'')-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1''H''-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol |
||
| image=Calcipotriol.svg |
| image=Calcipotriol.svg |
||
| CAS_number=112965-21-6 |
| CAS_number=112965-21-6 |
||
Revision as of 12:17, 21 December 2008
 | |
| Clinical data | |
|---|---|
| Pregnancy category | |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 5 to 6% |
| Metabolism | Hepatic |
| Excretion | Biliary |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.119.473 |
| Chemical and physical data | |
| Formula | C27H40O3 |
| Molar mass | 412.605 g/mol g·mol−1 |
Calcipotriol (INN) or calcipotriene (USAN) is a synthetic derivative of calcitriol or Vitamin D. It is used in the treatment of psoriasis, marketed under the trade name Dovonex or Daivonex.
Mechanism
The efficacy of calcipotriol in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of Vitamin D in an osteoporosis study. Unexpectedly, a patient's psoriasis lesions dramatically disappeared. [1]
The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it has been shown to have comparable affinity with calcitriol (Vit D) for the Vitamin D receptor, while being less than 1% as active as the calcitriol in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes.
Usage and Efficacy
Available as a cream, ointment or scalp solution (50mcg/mL), Calcipotriol is applied twice daily to plaque psoriasis on the body or scalp, but not the face. Improvement is usually detectable within 2 weeks. Most patients show some improvement, slightly more so than is seen with the use of corticosteroids alone. Tachyphylaxis does not occur, an improvement over glucocorticoid therapy.[2]
Side effects
Calcipotriol has been shown in clinical trials to have an excellent safety profile. [3] Reports of hypercalcemia are rare.[4]
It is also available in combination with the synthetic glucocorticoid betamethasone under the trade name Taclonex.
References
- ^ Morimoto, S., Kumahara, Y. A patient with psoriasis cured by 1-α-hydroxyvitamin D3. Med. J. Osaka Univ., 1985, 35:51-54
- ^ Kragbelle, K. Treatment of psoriasis with calcipotriol and other Vitamin D analogues. J. Am. Acad. Dermatol., 1992, 27:1001-1008.
- ^ Brunton, Laurence. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th ed. McCraw-Hill, 2006. p. 1664. p. 1704-5.
- ^ Hardman et al. Hypercalcemia associated with calcipotriol (DOVONEX) treatment. Br Med J., 1993, 306:896.
External links
- Leo Pharmaceuticals Product Monograph- Detailed information from the manufacturers, includes the blood testing recommendation (.pdf document).
- Calcipotriene information - U.S. NLM/NIH
 | This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |