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Template:PBB G protein-coupled receptor 98, also known as GPR98, is a human protein and gene.^[1]

Template:PBB Summary

References

^ "Entrez Gene: GPR98 G protein-coupled receptor 98".

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+{{PBB|geneid=84059}}
-'''Khabrain Group Tv Channel 5'''
+'''G protein-coupled receptor 98''', also known as '''GPR98''', is a human protein and [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR98 G protein-coupled receptor 98| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84059| accessdate = }}</ref>
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{PBB_Summary
+| section_title =
+| summary_text = This gene encodes a member of the [[G-protein coupled receptor]] superfamily. The protein binds calcium and is expressed in the central nervous system. It is also known as ''very large G-protein coupled receptor 1'' because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment (5900 residues) includes 35 calcium binding [[Calx-beta domain]]s, and 6 [[EAR domain]]s. Mutations in this gene are associated with [[Usher syndrome]] 2 and familial febrile seizures. Several alternatively spliced transcripts have been described.<ref name="entrez" />
+}}
+==References==
+{{reflist}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=  }}
+*{{cite journal  | author=Staub E, Pérez-Tur J, Siebert R, ''et al.'' |title=The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. |journal=Trends Biochem. Sci. |volume=27 |issue= 9 |pages= 441–4 |year= 2002 |pmid= 12217514 |doi=  }}
+*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=  }}
+*{{cite journal  | author=Nakayama J, Hamano K, Iwasaki N, ''et al.'' |title=Significant evidence for linkage of febrile seizures to chromosome 5q14-q15. |journal=Hum. Mol. Genet. |volume=9 |issue= 1 |pages= 87–91 |year= 2000 |pmid= 10587582 |doi=  }}
+*{{cite journal  | author=Pieke-Dahl S, Möller CG, Kelley PM, ''et al.'' |title=Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q. |journal=J. Med. Genet. |volume=37 |issue= 4 |pages= 256–62 |year= 2000 |pmid= 10745043 |doi=  }}
+*{{cite journal  | author=Nikkila H, McMillan DR, Nunez BS, ''et al.'' |title=Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain. |journal=Mol. Endocrinol. |volume=14 |issue= 9 |pages= 1351–64 |year= 2001 |pmid= 10976914 |doi=  }}
+*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal  | author=Skradski SL, Clark AM, Jiang H, ''et al.'' |title=A novel gene causing a mendelian audiogenic mouse epilepsy. |journal=Neuron |volume=31 |issue= 4 |pages= 537–44 |year= 2001 |pmid= 11545713 |doi=  }}
+*{{cite journal  | author=McMillan DR, Kayes-Wandover KM, Richardson JA, White PC |title=Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 785–92 |year= 2002 |pmid= 11606593 |doi= 10.1074/jbc.M108929200 }}
+*{{cite journal  | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |journal=DNA Res. |volume=8 |issue= 6 |pages= 319–27 |year= 2002 |pmid= 11853319 |doi=  }}
+*{{cite journal  | author=Nakayama J, Fu YH, Clark AM, ''et al.'' |title=A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures. |journal=Ann. Neurol. |volume=52 |issue= 5 |pages= 654–7 |year= 2002 |pmid= 12402266 |doi= 10.1002/ana.10347 }}
+*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Weston MD, Luijendijk MW, Humphrey KD, ''et al.'' |title=Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. |journal=Am. J. Hum. Genet. |volume=74 |issue= 2 |pages= 357–66 |year= 2004 |pmid= 14740321 |doi=  }}
+*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
+*{{cite journal  | author=Fu GK, Wang JT, Yang J, ''et al.'' |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011 }}
+*{{cite journal  | author=Schwartz SB, Aleman TS, Cideciyan AV, ''et al.'' |title=Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 2 |pages= 734–43 |year= 2005 |pmid= 15671307 |doi= 10.1167/iovs.04-1136 }}
+*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+}}
+{{refend}}
+{{transmembranereceptor-stub}}
+{{G protein-coupled receptors}}
+[[Category:Receptors]]
+[[Category:G protein coupled receptors]]
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