Talk:Fluoroquinolone toxicity syndrome: Difference between revisions

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I copied the bulk of the material for this article from a users talk page User talk:96.254.65.104 who seems new to wikipedia. Administrators please remember that this article is in the very beginning stages of development and needs lots more work over the coming months so please remember that it is rated as start class and is brand new. Basically don't delete it please without giving it a chance to develop. I believe that once developed it will provide an excellent resource for doctors, pharmacists and patients alike on the subject of the toxicity of fluoroquinolones.--Literaturegeek | T@1k? 02:26, 22 January 2009 (UTC)[reply]

I had been reviewing that suggested addition since December (recently with help from MastCell). I have rewritten the article with our edited version, which is in accordance with WP:NPOV and WP:WEIGHT. This article should also probably be moved to Quinolone-associated tendinopathy, because a) it only covers tendon damage and b) this "syndrome", if you will, is associated with quinolones, not only fluoroquinolones. Fvasconcellos (t·c) 14:34, 22 January 2009 (UTC)[reply]

Hi FV, I am happy with rebalancing the article according to WP:NPOV and WP:WEIGHT standards. I am not sure about moving it to the suggested page because the toxicity profile of quinolones is extensive with regard to organ systems affected such as eyes, CNS, GI tract, muscuskeletal system, joints, peripheral nerve damage and so on. Infact CNS adverse effects are the most common adverse event from fluoroquinolones and can be very long lasting. I am planning on adding some info regarding CNS adverse effects.--Literaturegeek | T@1k? 16:30, 22 January 2009 (UTC)[reply]

P.S., I am sorry for jumping the gun and creating the page. I wasn't aware that you were still in the process of reviewing the material.--Literaturegeek | T@1k? 16:31, 22 January 2009 (UTC)[reply]

My suggestions

Create subsections on CNS toxicity and explore the type of toxicities experienced regarding the CNS and their duration. Like how for some people they are short lasting and for others can persist for months or even years in cases of neurotoxicity. Create another section on occular toxicity and one on tendon and muscular toxicity and so on. Have a few short paragraphs on each of the toxicities. This information is greatly needed, especially for people suffering adverse toxicities of fluoroquinolones. The types of readers of this article, eg doctors, pharmacists and patients/victims of fluoroquinolones are going to be much more interested in the types of potential toxicities and how long they last for and so forth. A section on the mechanisms of toxicity would be of great value as well eg on GABA_A receptor antagonism and cellular toxicity. This may interest professionals, pharmacists, doctors etc. There is more than enough information on the legal and campaign side of the toxicity of fluoroquinolones so wiki editors please try and expand now on the actual fluoroquinolone toxicity syndrome as suggested above, describe it and use where ever possible credible peer reviewed sources.--Literaturegeek | T@1k? 02:34, 22 January 2009 (UTC)[reply]

I certainly hope creating this article was a good idea—this has the potential to quickly become a content fork. Fvasconcellos (t·c) 14:35, 22 January 2009 (UTC)[reply]

Fluoroquinolone toxicity syndrome or quinolone toxicity syndrome is the side effects which occur as a direct result of the ingestion of fluoroquinolone antibiotic drugs. Side effects can be for some people severe, prolonged and in some cases permanent and disabling. The dose, length of time and number of exposures to fluoroquinolones as well as combination with corticosteroids or NSAIDs can increase the toxicity of fluoroquinolones. Whilst people of all ages can experience the fluoroquinolone toxicity syndrome, the elderly and especially the young are particularly more susceptible to the toxic effects of fluoroquinolones. Fluoroquinolones are not licensed for use in children due to increased toxicity except in cases of cystic fibrosis. Fluroquinolones are also contraindicated during pregnancy.

There are a number of factual errors in this opening statement.

First this is NOT a side effect. This is to be considered an adverse reaction. Side effects abate once you quit taking the drug. Adverse reactions for the most part do not.

The dose, length of time and number of exposures to fluoroquinolones as well as combination with corticosteroids or NSAIDs have shown to have little to do with the overall toxicity of fluoroquinolones. Numerous patients have reported severe and disabling adverse reactions with as little as ONE dose without any of the various risk factors cited to by the manufacturers, including combination with corticosteroids or NSAIDs. Corticosteroids in and of themselves are associated with tendon ruptures. And the use of NSAIDS is contraindicated only because of the quinolones screwing with GABA receptors. In people prone to seizures the use of a NSAID together with the quinolones may induce a seizure for this reason. As such you are not increasing the toxicity, as it is already there, you are simply having a stronger reaction to it.

Levaquin and cipro both are licensed for pediatric use to treat anthrax. Cipro is licensed for pediatric use to treat a variety of severe urinary tract infections. NONE of the fluoroquinolones are licensed for pediatric use to treat cystic fibrosis. This is an off label use for compassionate reasons, but it is NOT a licensed use.

I have listed the numerous serious adverse reactions to this class on the fqresearch site, together with the supporting documentation. This may be an excellent jumping off point for those who are involved in writing this article. Due to numerous other projects I am already working on regarding these issues I simply do not have any hours left in the day to contribute a whole lot to this article. But as I have stated all the research has been done, including the citations and can be found on the research site which would make the fact checking a whole lot easier for those who wish to add to this article. Regards, David Fuller, Director, Fluoroquinolone Toxicity Research Foundation.96.254.65.104 (talk) 05:38, 23 January 2009 (UTC)[reply]