Adult-onset Still's disease: Difference between revisions
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The diagnosis is clinical, not based upon [[serology]].<ref name="pmid17538564">{{cite journal |author=Efthimiou P, Kontzias A, Ward CM, Ogden NS |title=Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy? |journal=Nat Clin Pract Rheumatol |volume=3 |issue=6 |pages=328–35 |year=2007 |month=June |pmid=17538564 |doi=10.1038/ncprheum0510 |url=http://dx.doi.org/10.1038/ncprheum0510}}</ref> |
The diagnosis is clinical, not based upon [[serology]].<ref name="pmid17538564">{{cite journal |author=Efthimiou P, Kontzias A, Ward CM, Ogden NS |title=Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy? |journal=Nat Clin Pract Rheumatol |volume=3 |issue=6 |pages=328–35 |year=2007 |month=June |pmid=17538564 |doi=10.1038/ncprheum0510 |url=http://dx.doi.org/10.1038/ncprheum0510}}</ref> |
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The disease typically affects 16-35 year olds and presents with arthralgia, elevated serum ferritin, a 'salmon-pink' rash, pyrexia and lymphadenopathy. Rheumatoid factor (RF) and anti-nuclear antibody (ANA) are classically negative. |
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A common 'differential diagnosis' for Still's is [[Lyme disease]]. |
A common 'differential diagnosis' for Still's is [[Lyme disease]]. |
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Revision as of 15:16, 29 April 2009
| Adult-onset Still's disease | |
|---|---|
| Specialty | Rheumatology  |
Adult-onset Still's disease is a form of rheumatoid arthritis that was characterized by Bywaters in 1971.[1]
The "Still" is for English physician Sir George Frederic Still (1861-1941). [2][3]
The condition "juvenile-onset Still disease" is now usually grouped under juvenile rheumatoid arthritis. However, there is some evidence that the two conditions are closely related.[4]
The diagnosis is clinical, not based upon serology.[5]
The disease typically affects 16-35 year olds and presents with arthralgia, elevated serum ferritin, a 'salmon-pink' rash, pyrexia and lymphadenopathy. Rheumatoid factor (RF) and anti-nuclear antibody (ANA) are classically negative.
A common 'differential diagnosis' for Still's is Lyme disease.
References
- ^ Bywaters EG (1971). "Still's disease in the adult". Ann. Rheum. Dis. 30 (2): 121–33. PMC 1005739. PMID 5315135.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ synd/1773 at Who Named It?
- ^ G. F. Still. A special form of joint disease met with in children. Doctoral dissertation, Cambridge, 1896.
- ^ Luthi F, Zufferey P, Hofer MF, So AK (2002). ""Adolescent-onset Still's disease": characteristics and outcome in comparison with adult-onset Still's disease". Clin. Exp. Rheumatol. 20 (3): 427–30. PMID 12102485.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Efthimiou P, Kontzias A, Ward CM, Ogden NS (2007). "Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy?". Nat Clin Pract Rheumatol. 3 (6): 328–35. doi:10.1038/ncprheum0510. PMID 17538564.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)