Mir-96 microRNA: Difference between revisions
No edit summary |
Added image. |
||
| Line 1: | Line 1: | ||
{{Rfam_box|acc= |
{{Rfam_box|acc=RNA_secondary_structure_and_sequence_conservation_for_miR-96|description=mir-96 microRNA precursor family|abbreviation=mir-96|type=Gene; miRNA;|avg_length=78.3|avg_identity=74|ss=Predicted; WAR|se=miRBase; Wilkinson A|type=Gene; miRNA;}} |
||
'''miR-96 microRNA precursor''' is a small [[non-coding RNA]] that regulates [[gene expression]]. [[microRNAs]] are transcribed as ~80 [[nucleotide]] precursors and subsequently processed by the [[Dicer]] enzyme to give a ~23 nucleotide products. In this case the mature sequence comes from the 5' arm of the precursor. |
'''miR-96 microRNA precursor''' is a small [[non-coding RNA]] that regulates [[gene expression]]. [[microRNAs]] are transcribed as ~80 [[nucleotide]] precursors and subsequently processed by the [[Dicer]] enzyme to give a ~23 nucleotide products. In this case the mature sequence comes from the 5' arm of the precursor. |
||
Revision as of 22:12, 2 May 2009
| Mir-96 microRNA | |
|---|---|
| Identifiers | |
| Other data | |
| PDB structures | PDBe |
miR-96 microRNA precursor is a small non-coding RNA that regulates gene expression. microRNAs are transcribed as ~80 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~23 nucleotide products. In this case the mature sequence comes from the 5' arm of the precursor. [1] The mature products are thought to have regulatory roles through complementarity to mRNA. These microRNAs are expressed specifically in the inner ear and the adult eye.[2][3]
miR-96 is thought to be conserved within Nephrozoa, i.e. the Deuterostomes and Protostomes. [4]
Variation within the seed region of mature miR-96 has been associated with autosomal dominant, progressive hearing loss in humans and mice. The homozygous mutant mice were profoundly deaf, showing no cochlear responses. [5] [6] [7]
References
- ^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. PMID 11914277.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Weston MD, Pierce ML, Rocha-Sanchez S, Beisel KW, Soukup GA (2006). "MicroRNA gene expression in the mouse inner ear". Brain Res. 1111 (1): 95–104. PMID 16904081.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D (2007). "MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster". J Biol Chem. 282 (34): 25053–66. PMID 17597072.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wheeler BM, Heimberg AM, Moy VN, Sperling EA, Holstein TW, Heber S, Peterson KJ. "The deep evolution of metazoan microRNAs". Evol Dev. 11 (1): 50–68. PMID 19196333.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Mencía A, Modamio-Høybjør S, Redshaw N, Morín M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA (2009). "Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss". Nat Genet. 41 (5): 609–13. PMID 19363479.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C, van Dongen S, Abreu-Goodger C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP (2009). "An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice". Nat Genet. 41 (5): 614–8. PMID 19363478.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Soukup GA (2009). "Little but loud: Small RNAs have a resounding affect on ear development". Brain Res. PMID 19245798.
Media reports
External links
- Page for the mir-96 microRNA precursor family at Rfam
- miRBase page for the mir-96 microRNA precursor family
- HGNC page for the mir-96 microRNA precursor family
- OMIM page for the mir-96 microRNA precursor family
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |