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==Interactions==
==Interactions==
Etodolac should be avoided by patients with a history of [[asthma]] attacks, [[Urticaria|hives]], or other [[Allergy|allergic reactions]] to [[aspirin]] or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with [[peptic ulcer]] disease or poor [[Renal physiology|kidney function]], since this medication can aggravate both conditions. Etodolac is generally used with caution in patients taking blood thinning medications ([[anticoagulant]]s), such as [[warfarin]] (Coumadin), because of increased risk of [[bleeding]]. Patients taking [[lithium]] can develop toxic blood lithium levels. Additionally, Etodolac has been found to interact with certain anti-depressant medications, such as [[sertraline]] or ([[fluxtolene]]), can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking [[ciclosporin]] (Sandimmune) can develop kidney toxicity. Use in [[children]] has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of the procedure.
Etodolac should be avoided by patients with a history of [[asthma]] attacks, [[Urticaria|hives]], or other [[Allergy|allergic reactions]] to [[aspirin]] or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with [[peptic ulcer]] disease or poor [[Renal physiology|kidney function]], since this medication can aggravate both conditions. Etodolac is generally used with caution in patients taking blood thinning medications ([[anticoagulant]]s), such as [[warfarin]] (Coumadin), because of increased risk of [[bleeding]]. Patients taking [[lithium]] can develop toxic blood lithium levels. Additionally, Etodolac has been found to interact with certain anti-depressant medications, such as [[sertraline]] or ([[fluoxetine]]), can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking [[ciclosporin]] (Sandimmune) can develop kidney toxicity. Use in [[children]] has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of the procedure.


Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.
Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.

Revision as of 21:27, 31 May 2009

Etodolac
Clinical data
Routes of
administration		oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding100%
Metabolismliver
Elimination half-life7.3 ± 4.0 hours
Excretionrenal
Identifiers
  • 2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.157.848 Edit this at Wikidata
Chemical and physical data
FormulaC17H21NO3
Molar mass287.35 g/mol g·mol−1
3D model (JSmol)
Melting point145–148 °C (293–298 °F)
Solubility in water3.92e-02 mg/mL [ALOGPS] mg/mL (20 °C)
  • CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) - of the arylalkanoic acids sub-group - effective in treating pain and inflammation in the body [2].

It is an inhibitor of cyclooxygenase.[3]

Main article: NSAIDs

Preparations

Etodolac is manufacturered by Shire under the tradename Lodine SR[2] and by Meda Pharmacuticals under the name Eccoxolac [4]. Non-proprietry etodolac is also available [5]

Indications

Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis [6]. It is increasingly being found in large seizures of heroin as an adulterant.

Dosing

Sustained release dosing is 600 mg once-a-day [2][7]. Normal release is 400-600 mg daily in two divided doses or a single dose [4][5]

Interactions

Etodolac should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Etodolac is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Additionally, Etodolac has been found to interact with certain anti-depressant medications, such as sertraline or (fluoxetine), can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking ciclosporin (Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of the procedure.

Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.

Box, strip and tablet of Etodolac (Lodine SR) 600mg

Pregnancy

Etodolac is generally avoided during pregnancy.

Nursing mothers

Etodolac is generally avoided in nursing mothers.

Side Effects

Etodolac may cause side effects, or adverse drug reactions. Tell your doctor if any of these symptoms are severe or do not go away:

constipation, diarrhea, gas or bloating, vomiting, headache, dizziness, ringing in the ears, runny nose, sore throat, blurred vision.

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more etodolac until you speak to your doctor:

unexplained weight gain, swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs, fever or chills, blisters, rash, itching, hives, hoarseness, difficulty breathing or swallowing, yellowing of the skin or eyes, excessive tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, flu-like symptoms, pale skin, fast heartbeat, cloudy, discolored, or bloody urine, difficult or painful urination, back pain.

Etodolac may cause other side effects.

References

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b c Summary of Product Characteristics Lodine SR
  3. ^ Sugimoto T, Aoyama M, Kikuchi K; et al. (2007). "Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis". Internal medicine (Tokyo, Japan). 46 (13): 1055–8. PMID 17603251. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  4. ^ a b Summary of Product Characteristics Eccoxolac
  5. ^ a b BNF 55: Etodolac preparations
  6. ^ BNF 55 - Etodolac
  7. ^ BNF 55: Lodine SR
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