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==TGEV Biology== |
==TGEV Biology== |
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TGEV belongs to the coronavirus family. It is an enveloped virus with a positive single stranded RNA genome. TGEV has three major structural porteins, which are phosphoprotein (N), integral membrane protein (E1), and large glycoprotein (E2). The N protein encapsulates the genomic RNA, and the S protein forms viral projections. |
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The 3' segment of about 8000 nucleotides encodes subgenomic RNAs. The remaining part of the genome encodes viral replicase. The three largest gene sequence from 5' to 3' is in the order of E2 to E1 to N. There are about seven other open reading frames that are not structurally related. There are very little overlaps among the genes, and is densely packed. A negative strand is synthesized to serve as a template for transcribing RNAs of one genome size and several subgenome sized RNAs. |
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The E2 protein forms a petal-shaped 20nm long projection from the virus's surface. The E2 protein is thought to be involved in pathogenesis by helping the virus enter the host cytoplasm. The E2 protein initially has 1447residues, and then a short hydrophobic sequence is cleaved. After glycosylation of the protein in the golgi, the protein is then incorporated into the new virus. There are several functional domains within the E2 protein. A 20 residue hydrophobic segment at the C-terminus anchors the protein in the lipid membrane. The rest of the protein is divided into two parts, a hydrophilic stretch that is inside the virus and a cysteine rich stretch that are possibly fatty acylation sites. The E1 protein is mostly embedded in the lipid envelop and hence plays an essential role in virus architecture. The E1 protein is postulated to interact with the lymphocyte membrane, which leads to the induction of IFN-coding genes. |
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==TGEV Morphology== |
==TGEV Morphology== |
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==External links== |
==External links== |
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* [http://patric.vbi.vt.edu/organism/overview.php?organismId=5 Coronavirus] (from [http://patric.vbi.vt.edu/ PATRIC] the PathoSystems Resource Integration Center, a [http://www3.niaid.nih.gov/ NIAID] Bioinformatics Resource Center) |
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* [http://www.microbiologybytes.com/virology/Coronaviruses.html MicrobiologyBytes: Coronaviruses] |
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* [http://www.virology.net/Big_Virology/BVRNAcorona.html Pictures of coronaviruses] |
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* [http://www.who.int/mediacentre/releases/2003/pr31/en/ WHO press release identifying and naming the SARS virus] |
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* [http://www.virusdiscovery.com Human coronaviruses and identification of unknown human pathogens] |
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* [http://www.expasy.org/viralzone/all_by_species/128.html '''Viralzone''': Coronavirus] |
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{{Common Cold}} |
{{Common Cold}} |
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{{Viral diseases}} |
{{Viral diseases}} |
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Revision as of 22:02, 8 December 2009
| Transmissible Gastroenteritis Coronavirus | |
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| Scientific classification | |
| Family: | |
| Genus: | Coronavirus
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Transmissible Gastroenteritis Coronavirus (TGEV) is a species of animal virus belonging to the family Coronaviridae.[1] TGEV are enveloped viruses with a positive-sense single-stranded RNA genome and a helical symmetry. The genomic size of coronaviruses ranges from approximately 28.6 kilobases.
Proteins that contribute to the overall structure of TGEV includes the spike (S), envelope (E), membrane (M) and nucleocapsid (N). TGEV is a group I coronavirus. Other group 1 coronaviruses includeCanine coronavirus, Feline coronavirus, Human coronavirus 229E, and Porcine epidemic diarrhea virus.
TGEV Biology
TGEV belongs to the coronavirus family. It is an enveloped virus with a positive single stranded RNA genome. TGEV has three major structural porteins, which are phosphoprotein (N), integral membrane protein (E1), and large glycoprotein (E2). The N protein encapsulates the genomic RNA, and the S protein forms viral projections.
The 3' segment of about 8000 nucleotides encodes subgenomic RNAs. The remaining part of the genome encodes viral replicase. The three largest gene sequence from 5' to 3' is in the order of E2 to E1 to N. There are about seven other open reading frames that are not structurally related. There are very little overlaps among the genes, and is densely packed. A negative strand is synthesized to serve as a template for transcribing RNAs of one genome size and several subgenome sized RNAs.
The E2 protein forms a petal-shaped 20nm long projection from the virus's surface. The E2 protein is thought to be involved in pathogenesis by helping the virus enter the host cytoplasm. The E2 protein initially has 1447residues, and then a short hydrophobic sequence is cleaved. After glycosylation of the protein in the golgi, the protein is then incorporated into the new virus. There are several functional domains within the E2 protein. A 20 residue hydrophobic segment at the C-terminus anchors the protein in the lipid membrane. The rest of the protein is divided into two parts, a hydrophilic stretch that is inside the virus and a cysteine rich stretch that are possibly fatty acylation sites. The E1 protein is mostly embedded in the lipid envelop and hence plays an essential role in virus architecture. The E1 protein is postulated to interact with the lymphocyte membrane, which leads to the induction of IFN-coding genes.
TGEV Morphology
TGEV pathology
Clinical Considerations
Engineering TGEV coronavirus
References
- ^ Thiel V (editor). (2007). Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-16-5.
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