COUP-TFI: Difference between revisions
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== Interactions == |
== Interactions == |
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COUP-TFI has been shown to [[Protein-protein interaction|interact]] with [[ |
COUP-TFI has been shown to [[Protein-protein interaction|interact]] with [[estrogen receptor alpha|ESR1]],<ref name="pmid12093745">{{cite journal | author = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = EMBO J. | volume = 21 | issue = 13 | pages = 3443–53 | year = 2002 | month = July | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 | url = | issn = }}</ref> [[BCL11A]]<ref name="pmid10744719">{{cite journal | author = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | month = April | pmid = 10744719 | doi = | url = | issn = }}</ref> and [[BCL11B]].<ref name=pmid10744719/> |
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==References== |
==References== |
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Revision as of 14:21, 6 January 2010
Template:PBB COUP Transcription Factor 1 (abbreviated as COUP-TF1) also known as Nuclear Receptor subfamily 2, group F, member 1 (abbreviated as NR2F1) is a protein that in humans is encoded by the NR2F1 gene.[1][2]
This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter)) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. It interacts with COPS2.[5]
Interactions
COUP-TFI has been shown to interact with ESR1,[6] BCL11A[7] and BCL11B.[7]
References
- ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
- ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. PMID 8530078.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. PMC 367207. PMID 3796602.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 8413. PMID 10207062.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. PMID 10744719.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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