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{{PBB|geneid=2768}}
{{PBB|geneid=2768}}
'''Guanine nucleotide-binding protein subunit alpha-12''' is a [[protein]] that in humans is encoded by the ''GNA12'' [[gene]].<ref name="pmid8423800">{{cite journal | author = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Mol Cell Biol | volume = 13 | issue = 2 | pages = 762–8 | year = 1993 | month = Feb | pmid = 8423800 | pmc = 358958 | doi = }}</ref><ref name="pmid16247467">{{cite journal | author = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | year = 2006 | month = Feb | pmid = 16247467 | pmc = | doi = 10.1038/sj.onc.1209132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref>
'''Guanine nucleotide-binding protein subunit alpha-12''' is a [[protein]] that in humans is encoded by the ''GNA12'' [[gene]].<ref name="pmid8423800">{{cite journal | author = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, [[Stuart A. Aaronson|Aaronson SA]] | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Mol Cell Biol | volume = 13 | issue = 2 | pages = 762–8 | year = 1993 | month = Feb | pmid = 8423800 | pmc = 358958 | doi = }}</ref><ref name="pmid16247467">{{cite journal | author = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | year = 2006 | month = Feb | pmid = 16247467 | pmc = | doi = 10.1038/sj.onc.1209132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref>


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Revision as of 03:37, 7 January 2010

Template:PBB Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]

Template:PBB Summary

Interactions

GNA12 has been shown to interact with ARHGEF1,[4] PPP5C,[5] ARHGEF12,[6][7] Heat shock protein 90kDa alpha (cytosolic), member A1[8] and TEC.[7]

References

  1. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Mol Cell Biol. 13 (2): 762–8. PMC 358958. PMID 8423800. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Kumar RN, Shore SK, Dhanasekaran N (2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
  4. ^
  5. ^ Yamaguchi, Yoshiaki (2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. 12 (15). England: 1353–8. ISSN 0960-9822. PMID 12176367. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  6. ^ Fukuhara, S (2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2–3). NETHERLANDS: 183–8. ISSN 0014-5793. PMID 11094164. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  7. ^ a b Suzuki, Nobuchika (2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. 100 (2). United States: 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMID 12515866. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  8. ^ Vaiskunaite, R (2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". J. Biol. Chem. 276 (49). United States: 46088–93. doi:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)

See also

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