Tissue inhibitor of metalloproteinase: Difference between revisions

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The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.

Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.

The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.

The role of the pro-MMP-9/TIMP-1 complex is still unknown.

External links

Tissue+Inhibitor+of+Metalloproteinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Brew K, Dinakarpandian D, Nagase H (2000). "Tissue inhibitors of metalloproteinases: evolution, structure and function". Biochim Biophys Acta. 1477 (1–2): 267–83. PMID 10708863.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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	The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue ~~inhibitor~~ of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: ''[[TIMP1]]'', ''[[TIMP2]]'', ''[[TIMP3]]'' and ''[[TIMP4]]''.		The [[matrix metalloproteinase]]s are inhibited by specific endogenous '''tissue inhibitors of metalloproteinases''' (TIMPs), which comprise a family of four protease inhibitors: ''[[TIMP1]]'', ''[[TIMP2]]'', ''[[TIMP3]]'' and ''[[TIMP4]]''.

	Overall, all [[Matrix metalloproteinase\|MMP]]s are inhibited by TIMPs once they are activated but the [[gelatinase]]s ([[MMP2\|MMP-2]] and [[MMP9\|MMP-9]]) can form complexes with TIMPs when the enzymes are in the latent form.		Overall, all [[Matrix metalloproteinase\|MMP]]s are inhibited by TIMPs once they are activated but the [[gelatinase]]s ([[MMP2\|MMP-2]] and [[MMP9\|MMP-9]]) can form complexes with TIMPs when the enzymes are in the latent form.