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The '''Leuckart reaction''' is the [[chemical reaction]] of ammonium salts of [[formic acid]] with [[aldehyde]]s (or [[ketone]]s) to form [[amine]]s by [[reductive amination]].{{Ref|Leuckart1885}} The reaction is named after [[Rudolf Leuckart (chemist)|Rudolf Leuckart |
The '''Leuckart reaction''' is the [[chemical reaction]] of ammonium salts of [[formic acid]] with [[aldehyde]]s (or [[ketone]]s) to form [[amine]]s by [[reductive amination]].{{Ref|Leuckart1885}} The reaction is named after [[Rudolf Leuckart (chemist)|Rudolf Leuckart]]. |
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[[Image:Leuckart Reaction Scheme.png|center|400px|The Leuckart reaction]] |
[[Image:Leuckart Reaction Scheme.png|center|400px|The Leuckart reaction]] |
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Revision as of 20:22, 6 April 2010
The Leuckart reaction is the chemical reaction of ammonium salts of formic acid with aldehydes (or ketones) to form amines by reductive amination.[1] The reaction is named after Rudolf Leuckart.
In addition to ammonia, primary and secondary amines are also successful.[2] Formamide or substituted formamides can also be used instead of ammonium formate.
When excess formic acid is used, the reaction is called the Leuckart-Wallach reaction.[3][4] The reaction is named after Rudolf Leuckart and Otto Wallach.
References
- ^ Leuckart, R. Ber. 1885, 18, 2341.
- ^ deBenneville, P. L.; Macartney, J. H. J. Am. Chem. Soc. 1950, 72, 3073 - 3075. (doi:10.1021/ja01163a074)
- ^ Wallach, O. Ann. 1892, 272, 99.
- ^ Moore Organic Reactions 1949, 5, 301. (Review)
See also
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