Best Friend

Best Friend may refer to:

• Best Friend, someone (singular) with whom one shares the strongest possible kind of friendship(s).
• Best Friend of Charleston, an early railroad locomotive

Best Friends may refer to:

• Best Friends Animal Society, the largest animal rescue sanctuary in the United States
• Best Friends (film), a 1982 feature film, starring Goldie Hawn and Burt Reynolds
• Best Friends, a children's novel by Jacqueline Wilson
• "Best Friends," a song by Ron Sexsmith from his 2002 album Cobblestone Runway
• "Best Friends", the German title of Nappers Never Sleep (Fillmore! episode)
• Best Friends (Main Street book), part of the Main Street book series

In music:

• Best Friends, an album created by Adnan Sami
• "Best Friend", an album by Hillsong United (band)
• "Best Friend", a song by The Beat (The English Beat) from their 1980 album I Just Can't Stop It
• "Best Friend", a song by the Danish band Toy-Box from their 1999 album Fantastic
• "Best Friend", a song by 50 Cent from the 2005 Get Rich or Die Tryin' Soundtrack
• "Best Friend", a song by Brandy Norwood
• "Best Friend", a song by Harry Nilsson
• "Best Friend", a song by Toni Braxton from their 1993 album Toni Braxton
• "Best Friend", a song by Kana Nishino
• Best Fwends, a musical group from Austin, Texas
• "Best Friends", a song by Amy Winehouse