Stauffer syndrome: Difference between revisions
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'''Stauffer [[syndrome]]''' is a constellation of [[sign (medicine)|sign]]s and [[symptom]]s of [[liver]] dysfunction that arise due to presence of [[renal cell carcinoma]]<ref>{{EMedicineDictionary|Stauffer+syndrome}}</ref> |
'''Stauffer [[syndrome]]''' was described initially by Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN. This condition is a constellation of [[sign (medicine)|sign]]s and [[symptom]]s of [[liver]] dysfunction that arise due to presence of [[renal cell carcinoma]]<ref>{{EMedicineDictionary|Stauffer+syndrome}}</ref>, and, more rarely in connection with other malignant neoplasms. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a [[paraneoplastic syndrome]].<ref name=jakse>{{cite journal |author=Jakse G, Madersbacher H |title=[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)] |journal=Wien Klin Wochenschr |volume=90 |issue=8 |pages=268–70 |year=1978 |pmid=636440}}</ref> |
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It leads to elevated [[liver function test]]s, which results from [[cholestasis]], i.e. a cessation of [[bile]] flow. The symptoms resolve if the renal cell cancer is successfully treated.<ref name=jakse/> |
It leads to elevated [[liver function test]]s, which results from [[cholestasis]], i.e. a cessation of [[bile]] flow. The symptoms resolve if the renal cell cancer is successfully treated.<ref name=jakse/> |
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Revision as of 18:02, 15 June 2010
| Stauffer syndrome |
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Stauffer syndrome was described initially by Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN. This condition is a constellation of signs and symptoms of liver dysfunction that arise due to presence of renal cell carcinoma[1], and, more rarely in connection with other malignant neoplasms. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a paraneoplastic syndrome.[2]
It leads to elevated liver function tests, which results from cholestasis, i.e. a cessation of bile flow. The symptoms resolve if the renal cell cancer is successfully treated.[2]
Eponym
It was first characterized in 1961.[3][4]
References
- ^ Template:EMedicineDictionary
- ^ a b Jakse G, Madersbacher H (1978). "[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)]". Wien Klin Wochenschr. 90 (8): 268–70. PMID 636440.
- ^ Stauffer MH (1961). "Nephrogenic hepatomegaly". Gastroenterology. 40: 694.
- ^ Morla D, Alazemi S, Lichtstein D (2006). "Stauffer's syndrome variant with cholestatic jaundice: a case report". J Gen Intern Med. 21 (7): C11–3. doi:10.1111/j.1525-1497.2006.00448.x. PMC 1924715. PMID 16808761.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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