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{{PBB|geneid=7025}}
{{PBB|geneid=7025}}
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}</ref><ref name="pmid8530078">{{cite journal | author = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | year = 1995 | month = September | pmid = 8530078 | doi = | url = | issn = }}</ref>
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}</ref><ref name="pmid8530078">{{cite journal | author = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | year = 1995 | month = September | pmid = 8530078 | doi = 10.1006/geno.1995.1237| url = | issn = }}</ref>


This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s. Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | author = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Mol. Cell. Biol. | volume = 6 | issue = 12 | pages = 4259–67 | date=1 December 1986| pmid = 3796602 | pmc = 367207 | url = http://mcb.asm.org/cgi/content/abstract/6/12/4259 | issn = }}</ref><ref name="pmid3040258">{{cite journal | author = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | year = 1987 | month = August | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | url = | issn = }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal | author = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocr. Rev. | volume = 18 | issue = 2 | pages = 229–40 | year = 1997 | month = April | pmid = 9101138 | doi = | url = | issn = }}</ref>
This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s. Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | author = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Mol. Cell. Biol. | volume = 6 | issue = 12 | pages = 4259–67 | date=1 December 1986| pmid = 3796602 | pmc = 367207 | url = http://mcb.asm.org/cgi/content/abstract/6/12/4259 | issn = }}</ref><ref name="pmid3040258">{{cite journal | author = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | year = 1987 | month = August | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | url = | issn = }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal | author = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocr. Rev. | volume = 18 | issue = 2 | pages = 229–40 | year = 1997 | month = April | pmid = 9101138 | doi = 10.1210/er.18.2.229| url = | issn = }}</ref>


== Interactions ==
== Interactions ==
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COUP-TFI has been shown to [[Protein-protein interaction|interact]] with:
COUP-TFI has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=30em}}
{{div col|colwidth=30em}}
* [[BCL11A]],<ref name="pmid10744719">{{cite journal | author = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | month = April | pmid = 10744719 | doi = | url = | issn = }}</ref>
* [[BCL11A]],<ref name="pmid10744719">{{cite journal | author = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | month = April | pmid = 10744719 | doi = 10.1074/jbc.275.14.10315| url = | issn = | pmc = 2819356 }}</ref>
* [[BCL11B]].<ref name=pmid10744719/>
* [[BCL11B]].<ref name=pmid10744719/>
* [[COPS2]].<ref name="pmid10207062">{{cite journal | author = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3383–94 | date=1 May 1999| pmid = 10207062 | pmc = 8413 | url = http://mcb.asm.org/cgi/content/abstract/19/5/3383 | issn = }}</ref> and
* [[COPS2]].<ref name="pmid10207062">{{cite journal | author = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3383–94 | date=1 May 1999| pmid = 10207062 | pmc = 8413 | url = http://mcb.asm.org/cgi/content/abstract/19/5/3383 | issn = }}</ref> and
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*{{cite journal | author=Sugiyama T, Wang JC, Scott DK, Granner DK |title=Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3446–54 |year= 2000 |pmid= 10652338 |doi=10.1074/jbc.275.5.3446 }}
*{{cite journal | author=Sugiyama T, Wang JC, Scott DK, Granner DK |title=Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3446–54 |year= 2000 |pmid= 10652338 |doi=10.1074/jbc.275.5.3446 }}
*{{cite journal | author=Vlahou A, Flytzanis CN |title=Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle. |journal=Dev. Biol. |volume=218 |issue= 2 |pages= 284–98 |year= 2000 |pmid= 10656770 |doi= 10.1006/dbio.1999.9456 }}
*{{cite journal | author=Vlahou A, Flytzanis CN |title=Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle. |journal=Dev. Biol. |volume=218 |issue= 2 |pages= 284–98 |year= 2000 |pmid= 10656770 |doi= 10.1006/dbio.1999.9456 }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315–22 |year= 2000 |pmid= 10744719 |doi=10.1074/jbc.275.14.10315 }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315–22 |year= 2000 |pmid= 10744719 |doi=10.1074/jbc.275.14.10315 | pmc=2819356 }}
*{{cite journal | author=Gay F, Anglade I, Gong Z, Salbert G |title=The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1627–48 |year= 2001 |pmid= 11043578 |doi=10.1210/me.14.10.1627 }}
*{{cite journal | author=Gay F, Anglade I, Gong Z, Salbert G |title=The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1627–48 |year= 2001 |pmid= 11043578 |doi=10.1210/me.14.10.1627 }}
*{{cite journal | author=You M, Fischer M, Cho WK, Crabb D |title=Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. |journal=Arch. Biochem. Biophys. |volume=398 |issue= 1 |pages= 79–86 |year= 2002 |pmid= 11811951 |doi= 10.1006/abbi.2001.2713 }}
*{{cite journal | author=You M, Fischer M, Cho WK, Crabb D |title=Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. |journal=Arch. Biochem. Biophys. |volume=398 |issue= 1 |pages= 79–86 |year= 2002 |pmid= 11811951 |doi= 10.1006/abbi.2001.2713 }}

Revision as of 16:56, 15 July 2010

Template:PBB COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2]

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]

Interactions

COUP-TFI has been shown to interact with:

References

  1. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
  2. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. PMC 367207. PMID 3796602.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Tsai SY, Tsai MJ (1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocr. Rev. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138. {{cite journal}}: Unknown parameter |month= ignored (help)
  6. ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  7. ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 8413. PMID 10207062.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

Template:PBB Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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