TANK-binding kinase 1: Difference between revisions
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==Interactions== |
==Interactions== |
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TANK-binding kinase 1 has been shown to [[Protein-protein_interaction|interact]] with [[NCK1]],<ref name=pmid7706279>{{cite journal |last=Chou |first=M M |authorlink= |coauthors=Hanafusa H |year=[[1995]]|month=Mar. |title=A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain |journal=J. Biol. Chem. |volume=270 |issue=13 |pages=7359–64 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7706279 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TRAF2]]<ref name=pmid14743216>{{cite journal |last=Bouwmeester |first=Tewis |authorlink= |coauthors=Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio |year=[[2004]]|month=Feb. |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue=2 |pages=97–105 |publisher= |location = England| issn = 1465-7392| pmid = 14743216 |
TANK-binding kinase 1 has been shown to [[Protein-protein_interaction|interact]] with [[NCK1]],<ref name=pmid7706279>{{cite journal |last=Chou |first=M M |authorlink= |coauthors=Hanafusa H |year=[[1995]]|month=Mar. |title=A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain |journal=J. Biol. Chem. |volume=270 |issue=13 |pages=7359–64 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7706279 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TRAF2]]<ref name=pmid14743216>{{cite journal |unused_data=DUPLICATE DATA: pmid = 14755267 |last=Bouwmeester |first=Tewis |authorlink= |coauthors=Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio |year=[[2004]]|month=Feb. |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue=2 |pages=97–105 |publisher= |location = England| issn = 1465-7392| pmid = 14743216 |doi = 10.1038/ncb1086 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10990461>{{cite journal |last=Bonnard |first=M |authorlink= |coauthors=Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel W J, Elia A J, Shillinglaw W, Mak T W, Cao Z, Yeh W C |year=[[2000]]|month=Sep. |title=Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription |journal=EMBO J. |volume=19 |issue=18 |pages=4976–85 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10990461 |doi = 10.1093/emboj/19.18.4976 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=314216 }}</ref> and [[TANK (gene)|TANK]].<ref name=pmid14743216/><ref name=pmid10581243>{{cite journal |last=Pomerantz |first=J L |authorlink= |coauthors=Baltimore D |year=[[1999]]|month=Dec. |title=NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase |journal=EMBO J. |volume=18 |issue=23 |pages=6694–704 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10581243 |doi = 10.1093/emboj/18.23.6694 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1171732 }}</ref> |
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==References== |
==References== |
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Revision as of 21:00, 27 August 2010
Template:PBB Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.[1][2][3]
Interactions
TANK-binding kinase 1 has been shown to interact with NCK1,[4] TRAF2[5][6] and TANK.[5][1]
References
- ^ a b Pomerantz JL, Baltimore D (2000). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
{{cite journal}}: Unknown parameter|month=ignored (help) Cite error: The named reference "pmid10581243" was defined multiple times with different content (see the help page). - ^ Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M (2000). "NAK is an IkappaB kinase-activating kinase". Nature. 404 (6779): 778–82. doi:10.1038/35008109. PMID 10783893.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: TBK1 TANK-binding kinase 1".
- ^ Chou, M M (1995). "A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain". J. Biol. Chem. 270 (13). UNITED STATES: 7359–64. ISSN 0021-9258. PMID 7706279.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: year (link) - ^ a b Bouwmeester, Tewis (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2). England: 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help); Unknown parameter|unused_data=ignored (help)CS1 maint: year (link) - ^ Bonnard, M (2000). "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription". EMBO J. 19 (18). ENGLAND: 4976–85. doi:10.1093/emboj/19.18.4976. ISSN 0261-4189. PMC 314216. PMID 10990461.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: year (link)
Further reading
{{PBB_Further_reading | citations =
- Chou MM, Hanafusa H (1995). "A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain". J. Biol. Chem. 270 (13): 7359–64. PMID 7706279.
- Chen ZJ, Parent L, Maniatis T (1996). "Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity". Cell. 84 (6): 853–62. doi:10.1016/S0092-8674(00)81064-8. PMID 8601309.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Zandi E, Chen Y, Karin M (1998). "Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate". Science. 281 (5381): 1360–3. doi:10.1126/science.281.5381.1360. PMID 9721103.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Bonnard M, Mirtsos C, Suzuki S; et al. (2000). "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription". EMBO J. 19 (18): 4976–85. doi:10.1093/emboj/19.18.4976. PMC 314216. PMID 10990461.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Kishore N, Huynh QK, Mathialagan S; et al. (2002). "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2". J. Biol. Chem. 277 (16): 13840–7. doi:10.1074/jbc.M110474200. PMID 11839743.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Chariot A, Leonardi A, Muller J; et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Li SF, Fujita F, Hirai M; et al. (2003). "Genomic structure and characterization of the promoter region of the human NAK gene". Gene. 304: 57–64. doi:10.1016/S0378-1119(02)01179-4. PMID 12568715.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Fitzgerald KA, McWhirter SM, Faia KL; et al. (2003). "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway". Nat. Immunol. 4 (5): 491–6. doi:10.1038/ni921. PMID 12692549.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Sharma S, tenOever BR, Grandvaux N; et al. (2003). "Triggering the interferon antiviral response through an IKK-related pathway". Science. 300 (5622): 1148–51. doi:10.1126/science.1081315. PMID 12702806.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Sato S, Sugiyama M, Yamamoto M; et al. (2004). "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling". J. Immunol. 171 (8): 4304–10. PMID 14530355.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Fujita F, Taniguchi Y, Kato T; et al. (2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - tenOever BR, Sharma S, Zou W; et al. (2004). "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity". J. Virol. 78 (19): 10636–49. doi:10.1128/JVI.78.19.10636-10649.2004. PMC 516426. PMID 15367631.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Kuai J, Wooters J, Hall JP; et al. (2005). "NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach". J. Biol. Chem. 279 (51): 53266–71. doi:10.1074/jbc.M411037200. PMID 15485837.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - {{cite journal | author=Buss H, Dörrie A, Schmitz ML, et al. |title=Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55633–43 |year= 2005 |pmid= 15489227 |doi= 10.1074/jbc.M409825200 }}
}}
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