Sarcoglycan: Difference between revisions
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The '''sarcoglycans''' are a family of [[transmembrane protein]]s<ref>{{MeshName|Sarcoglycans}}</ref> (α, β, γ, δ or ε) involved in the [[protein complex]] responsible for connecting the muscle fibre [[cytoskeleton]] to the [[extracellular matrix]], preventing damage the muscle fibre [[sarcolemma]] through shearing forces. |
The '''sarcoglycans''' are a family of [[transmembrane protein]]s<ref>{{MeshName|Sarcoglycans}}</ref> (α, β, γ, δ or ε) involved in the [[protein complex]] responsible for connecting the muscle fibre [[cytoskeleton]] to the [[extracellular matrix]], preventing damage the muscle fibre [[sarcolemma]] through shearing forces. |
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The [[dystrophin]] glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The '''sarcoglycan complex''' is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains <ref name="PUB00008631">{{cite journal |author=Zheng Y, Chockalingam PS, Cholera R, Oak SA, Jarrett HW, Thomason DB |title=Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy |journal=Am J Physiol Cell Physiol |volume=283 |issue=2 |pages=- |year=2002 |pmid=12107060}}</ref><ref name="PUB00008632">{{cite journal |author=Wheeler MT, Zarnegar S, Mcnally EM |title=zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy |journal=Hum. Mol. Genet. |volume=11 |issue=18 |pages=2147-2154 |year=2002 |pmid=12189167}}</ref>. |
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The disorders caused by the mutations of the sarcoglycans are called [[sarcoglycanopathies]]. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated [[limb-girdle muscular dystrophy]]. |
The disorders caused by the mutations of the sarcoglycans are called [[sarcoglycanopathies]]. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated [[limb-girdle muscular dystrophy]]. |
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{{Muscle tissue}} |
{{Muscle tissue}} |
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[[Category:Proteins]] |
[[Category:Proteins]] |
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{{InterPro content|IPR006875}} |
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Revision as of 22:31, 25 September 2010
| Sarcoglycan beta/gamma/delta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Sarcoglycan_1 | ||||||||
| Pfam | PF04790 | ||||||||
| InterPro | IPR006875 | ||||||||
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| Sarcoglycan alpha/epsilon | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Sarcoglycan_2 | ||||||||
| Pfam | PF05510 | ||||||||
| InterPro | IPR008908 | ||||||||
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Template:FixBunching The sarcoglycans are a family of transmembrane proteins[1] (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage the muscle fibre sarcolemma through shearing forces.
The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains [2][3].
The disorders caused by the mutations of the sarcoglycans are called sarcoglycanopathies. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated limb-girdle muscular dystrophy.
Genes
References
- ^ Sarcoglycans at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Zheng Y, Chockalingam PS, Cholera R, Oak SA, Jarrett HW, Thomason DB (2002). "Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy". Am J Physiol Cell Physiol. 283 (2): -. PMID 12107060.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wheeler MT, Zarnegar S, Mcnally EM (2002). "zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy". Hum. Mol. Genet. 11 (18): 2147–2154. PMID 12189167.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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