Talk:Muscarinic acetylcholine receptor

I've been studying the autonomic nervous system, and particularly the various ACh receptors and the drugs and substances, for alzheimers, parkinsons, IBS, cardiac drugs, bronchodilators, etc, background for famous drugs like scopolamine/atropine because this needs to be written and existing stuff tied together in Wikipedia and it struck me as a current weakness. I'm starting with muscarinic receptors, and hope to edit nicotinic receptors, and to a lesser extent, ach, sympathetic/parasympathetic/autonomous nervous system atropine/scopolamine, and to crete pages for dicycloverine/milverine/cimetropium etc, etc. This will take some time though.... Kaet 03:44, 8 Sep 2004 (UTC)

Hopefully you will forgive me using this discussion page to note some research which will be valuable in future (to myself, or some other poor sod), but which don't yet fit into the article itself.

• m1: not PTX, not CTX, G_q,G_i, slow EPSP at ganglion1, secretory glands23, cns23. IP3
• m2: PTX sensitive, not CTX, G_i,G_o,G_z, IPSP at ganglion1, smooth muscle13, myocardium2, cns23. -cAMP3
• m3: not PTX, not CTX, G_q,G_i, smooth muscle123, secretory glands23, cns23. IP release3
• m4: PTX sensitive, G_i, G_s? (would be CTX for G_s), smoothmuscle2, secretory glands2, cns23, -cAMP3
• m5: not PTX, cns3. IP3

Sorry about the delay half way through expanding this page. Caused by a work crisis. Should resume shortly. kaet

Hi, Kaet. I have expanded and edited the Parasympathetic page, if there is anything missing feel free to add it. Also, i am willing to help you out on your mass editing. =) see you around. --LowLifer 06:58, 4 October 2005 (UTC)

Added in "Also see Tiotropium". I am just a patient that uses the drug and I came to the conclusion it seems to block the nicotine (darn cigarettes) and open my airways. I have no ego to bruise so feel free to clean up.

Agonists and antagonists - go specific

Hello. the agonists and antagonists listed in the table should be more specific to the receptor, otherwise it makes no sense and we can simply write Acetyl choline in each one. So I've inserted specific agonists and antagonists for each receptor.vineetcoolguy 12:30, 19 August 2007 (UTC)

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"Atropine (To Dilate The Pupil)"

The sentence which reads "atorpine (to dilate the pupil) should be changed. Although atropine can and was once used to dilate the pupil in earlier times for cosmetic reasons, it is no longer used for this application and we realise the dangers of doing so. It should be noted there however that atropine is used in the clinic, especially emergency medicine where it is used to block the effects of organophosphate poisoning, increase heart rate and cardiac contractility and increase blood pressure. It is named on the World Health Organisations list of essential drugs for the emergency department resuscitation room. —Preceding unsigned comment added by 152.78.249.51 (talk) 10:38, 15 March 2009 (UTC)

muscarinic receptors on sweat glands

the muscarinic receptors on sweat glands has inhibitory effect or excitatory effect on erector muscle? Which I mean the muscarinic receptors cause the ligand-gated potassium channel to open ( IPSP ), or the ion channel to opens, allowing K+, Na+, Ca+2 to diffuse through ( EPSP )? Thanks a lot.