Chelidonium majus: Difference between revisions
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The latex could be employed as a [[caustic]] for healing small open wounds. Early studies of celandine showed that it causes [[contact dermatitis]] and eye irritation, particularly from contact with the poisonous red to yellow [[latex]] sap of the stem. This effect has not been observed in animal studies; no inflammation was observed in rabbit eye tests. The latex can leave a non-permanent stain. Stains on skin of the fingers are sometimes reported to cause eye irritation after rubbing the eyes or handling contact lenses. When any part of the plant causes eye irritation, wash it out with clear water and when needed seek medical help. The latex is also known to stain clothes. |
The latex could be employed as a [[caustic]] for healing small open wounds. Early studies of celandine showed that it causes [[contact dermatitis]] and eye irritation, particularly from contact with the poisonous red to yellow [[latex]] sap of the stem. This effect has not been observed in animal studies; no inflammation was observed in rabbit eye tests. The latex can leave a non-permanent stain. Stains on skin of the fingers are sometimes reported to cause eye irritation after rubbing the eyes or handling contact lenses. When any part of the plant causes eye irritation, wash it out with clear water and when needed seek medical help. The latex is also known to stain clothes. |
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The characteristic latex also contains [[proteolytic enzymes]] and the |
The characteristic latex also contains [[proteolytic enzymes]] and the phyto[[cystatin]] chelidostatin, a [[cysteine protease]] inhibitor. <ref>B. Rogelj et al., (1998) Phytochemistry 49 (6): 1645-9. PMID 9862139 </ref> These co-constituents could explain the topical use of greater celandine against warts and moles. |
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==Herbalism== |
==Herbalism== |
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Revision as of 02:59, 7 October 2010
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (April 2009) |
| Greater celandine | |
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| Scientific classification | |
| Kingdom: | |
| Division: | |
| Class: | |
| Order: | |
| Family: | |
| Genus: | Chelidonium
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| Species: | C. majus
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| Binomial name | |
| Chelidonium majus | |
Chelidonium majus (greater celandine; in Europe tetterwort, although in America the same name refers to bloodroot) is a herbaceous perennial plant, the only species in the genus Chelidonium. It is native to Europe and western Asia and introduced widely in North America.
The lesser celandine belongs to the same order (Ranunculales) as the greater celandine, but belongs to the buttercup family, whereas the greater celandine belongs to the poppy family.
Description
Greater celandine has an erect habit, and may reach 30 to 120 cm high. The leaves are lobed and crenate, 30 cm long. The sap is yellow to orange.
The flowers consist of four yellow petals, each about 1 cm long, with two sepals. A double-flowered variety occurs naturally. The flowers appear from late spring to summer in umbelliform cymes of about 4 flowers.
The seeds are small and black, borne in a long capsule. Each has an elaiosome, which attracts ants to disperse the seeds (myrmecochory).
It is considered an aggressive invasive plant in natural areas (both woods and fields). Control is mainly via pulling or spraying the plant before seed dispersal.
Pharmacology
The whole plant is toxic in moderate doses as it contains a range of isoquinoline alkaloids but there are numerous therapeutic uses when used at the correct dosage.[1] The main alkaloid present in the herb and root is coptisine. Other alkaloids present include berberine, chelidonine, sanguinarine and chelerythrine. Sanguinarine is particularly toxic with a lethal dose of only 18 mg per kg body weight.[2] Despite this acute toxicity, sanguinarine is present in such small quantities that the LD50 dose would require >50g of raw herb to be ingested. Caffeic acid derivatives are also present.
The effect of the fresh herb is of a mild analgesic, cholagogic, antimicrobial, oncostatic[3] and central nervous system sedative. In animal tests, celandine is shown to be cytostatic. An immune stimulating effect has also been noted. Some studies show that the alkaloid extraction can have the same effects. The alkaloids are known to cause immobilization in mice after being taken orally or injected. The alkaloids cause limpness and tone reduction of smooth muscle in rabbits. The alkaloids are also noted to stimulate the heart and lungs of frogs, cats and dogs, raising the blood pressure and widening the arteries.
The latex could be employed as a caustic for healing small open wounds. Early studies of celandine showed that it causes contact dermatitis and eye irritation, particularly from contact with the poisonous red to yellow latex sap of the stem. This effect has not been observed in animal studies; no inflammation was observed in rabbit eye tests. The latex can leave a non-permanent stain. Stains on skin of the fingers are sometimes reported to cause eye irritation after rubbing the eyes or handling contact lenses. When any part of the plant causes eye irritation, wash it out with clear water and when needed seek medical help. The latex is also known to stain clothes.
The characteristic latex also contains proteolytic enzymes and the phytocystatin chelidostatin, a cysteine protease inhibitor. [4] These co-constituents could explain the topical use of greater celandine against warts and moles.
Herbalism
The aerial parts and roots of greater celandine are used in herbalism. The above-ground parts are gathered during the flowering season and dried at high temperatures. The root is harvested in autumn between August and October and dried. The fresh rhizome is also used. Celandine has a hot and bitter taste. The latex has a narcotic fragrance.
Preparations are made from alcoholic and hot aqueous extractions (tea). The average daily dosage is 2 to 4 g, equivalent to 12 to 13 mg total alkaloids. For fluid extracts, the daily dosage is 1 to 2 ml of 1:1 25% alcoholic extraction, up to 3 times per day. For hot tea infusions, 1.5 dessert spoonsful left in boiling water for 10 minutes can be taken 3 times a day.
It was formerly used by gypsies as a foot refresher; modern herbalists use its purgative properties.[5] In Russia and in other countries it is used as a herbal aid in removing warts, papillomas and other skin malformations. It is also used in the mole and wart remover Wart Mole Vanish. See also Bloodroot, which has similar chemical composition and therapeutic use as greater celandine, particularly in warts and moles treatment.
Greater celandine acts as a mild sedative which has been used historically to treat asthma, bronchitis, and whooping cough. The herb's antispasmodic effect improves bile flow in the gallbladder and has been reputed to treat gallstones and gallbladder pain. As far back as Pliny the Elder and Dioscorides (1st century CE) this herb has been recognized as a useful detoxifying agent. The root has been chewed to relieve toothache.[6]
Gallery
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A cut stem dripping with yellow sap. -
seeds with elaiosomes
References
- ^ Gruenwald, Joerg (2000). PDR for Herbal Medicines. Thomson PDR. ISBN 1-56363-361-2.
- ^ Golob, Peter (1999). The use of spices and medicinals as bioactive protectants for grains. FAO Agricultural Services Bulletin. Vol. 137. Rome: Food and Agriculture Organization. ISBN 92-5-104294-2. Retrieved 2008-07-17.
{{cite book}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Natural Standard Drug Monograph. http://www.naturalstandard.com/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/aux3-greatercelandine.asp. Accessed June 16, 2009.
- ^ B. Rogelj et al., (1998) Phytochemistry 49 (6): 1645-9. PMID 9862139
- ^ Howard, Michael (1987-05-21). Traditional Folk Remedies. Century Paperbacks. Ebury Press. pp. 146–147. ISBN 978-0712617314.
- ^ Chevallier, Andrew (1996). The encyclopedia of medicinal plants. New York: DK Publishing. p. 185. ISBN 0-7894-1067-2.
External links
