MiR-132: Difference between revisions
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In molecular biology '''mir-132 microRNA''' is a short [[non-coding RNA|RNA]] molecule. [[MicroRNA]]s function to regulate the expression levels of other genes by several mechanisms. |
In molecular biology '''mir-132 microRNA''' is a short [[non-coding RNA|RNA]] molecule. [[MicroRNA]]s function to regulate the expression levels of other genes by several mechanisms, generally reducing protein levels though the cleavage of mRNAs or the repression of their translation. Several targets for miR-132 have been described, including mediators of infammation and synaptic transmission. |
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== See also == |
== See also == |
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Revision as of 13:31, 3 November 2010
| mir-132 | |
|---|---|
| Identifiers | |
| Symbol | mir-132 |
| Rfam | RF00662 |
| miRBase family | MIPF0000065 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-132 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, generally reducing protein levels though the cleavage of mRNAs or the repression of their translation. Several targets for miR-132 have been described, including mediators of infammation and synaptic transmission.
See also
Further reading
- ^ Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA (2010). "MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis". Nat Med. 16 (8): 909–14. PMID 20676106.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne RS, Gotch F, Boshoff C (2010). "miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator". Nat Cell Biol. 12 (5): 513–9. PMID 20418869.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M (2010). "Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132". Neuron. 65 (3): 373–84. PMID 20159450.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ O'Neill LA (2009). "Boosting the brain's ability to block inflammation via microRNA-132". Immunity. 31 (6): 854–5. PMID 20064444.
- ^ Shaked I, Meerson A, Wolf Y, Avni R, Greenberg D, Gilboa-Geffen A, Soreq H (2009). "MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase". Immunity. 31 (6): 965–73. PMID 20005135.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kawashima H, Numakawa T, Kumamaru E, Adachi N, Mizuno H, Ninomiya M, Kunugi H, Hashido K (2010). "Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression". Neuroscience. 165 (4): 1301–11. PMID 19958814.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A, Alford A, Waters KM (2009). "MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1". Mol Endocrinol. 23 (11): 1876–84. PMID 19819989.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Nudelman AS, DiRocco DP, Lambert TJ, Garelick MG, Le J, Nathanson NM, Storm DR (2010). "Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo". Hippocampus. 20 (4): 492–8. PMID 19557767.
{{cite journal}}: CS1 maint: multiple names: authors list (link)