Jump to content

PPP2CB: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m Citations: [Pu184]Tweaked: doi. You can use this bot yourself. Report bugs here.
m Minor fixes, replaced: 1997 → 1997 (3), year = 1993 | month = Apr | → date=Apr 1993| (4), date=Jan → date=January (3), → (5), | date=Apr 1 → | date=April 1 using AWB
Line 1: Line 1:
{{PBB|geneid=5516}}
{{PBB|geneid=5516}}
'''Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2CB'' [[gene]].<ref name="pmid8383590">{{cite journal | author = Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT | title = Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively | journal = Cytogenet Cell Genet | volume = 63 | issue = 1 | pages = 35–41 | year = 1993 | month = Apr | pmid = 8383590 | pmc = | doi =10.1159/000133497 }}</ref>
'''Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2CB'' [[gene]].<ref name="pmid8383590">{{cite journal | author = Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT | title = Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively | journal = Cytogenet Cell Genet | volume = 63 | issue = 1 | pages = 35–41 | date=April 1993| pmid = 8383590 | pmc = | doi =10.1159/000133497 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =
| section_title =
| summary_text = This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5516| accessdate = }}</ref>
| summary_text = This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5516| accessdate = }}</ref>
}}
}}


==Interactions==
==Interactions==
PPP2CB has been shown to [[Protein-protein interaction|interact]] with [[TLX1]],<ref name=pmid9009195>{{cite journal |last=Kawabe |first=T |authorlink= |coauthors=Muslin A J, Korsmeyer S J |year=[[1997]]|month=Jan. |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint |journal=[[Nature (journal)|Nature]] |volume=385 |issue=6615 |pages=454–8 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 9009195 |doi = 10.1038/385454a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPP2R1B]]<ref name=pmid12370081>{{cite journal |last=Zhou |first=Jin |authorlink= |coauthors=Pham Huong T, Ruediger Ralf, Walter Gernot |year=[[2003]]|month=Jan. |title=Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution |journal=Biochem. J. |volume=369 |issue=Pt 2 |pages=387–98 |publisher= |location = England| issn = 0264-6021| pmid = 12370081 |doi = 10.1042/BJ20021244 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223084 }}</ref> and [[PPP2R1A]].<ref name=pmid12370081/><ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref>
PPP2CB has been shown to [[Protein-protein interaction|interact]] with [[TLX1]],<ref name=pmid9009195>{{cite journal |last=Kawabe |first=T |authorlink= |coauthors=Muslin A J, Korsmeyer S J |date=January 1997|title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint |journal=[[Nature (journal)|Nature]] |volume=385 |issue=6615 |pages=454–8 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 9009195 |doi = 10.1038/385454a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPP2R1B]]<ref name=pmid12370081>{{cite journal |last=Zhou |first=Jin |authorlink= |coauthors=Pham Huong T, Ruediger Ralf, Walter Gernot |date=January 2003|title=Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution |journal=Biochem. J. |volume=369 |issue=Pt 2 |pages=387–98 |publisher= |location = England| issn = 0264-6021| pmid = 12370081 |doi = 10.1042/BJ20021244 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223084 }}</ref> and [[PPP2R1A]].<ref name=pmid12370081/><ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |date=January 2009|title=A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref>


==See also==
==See also==
Line 16: Line 16:
==References==
==References==
{{reflist}}
{{reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further_reading
| citations =
| citations =
*{{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=10.1016/S0006-2952(00)00424-X }}
*{{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=10.1016/S0006-2952(00)00424-X }}
*{{cite journal | author=Goedert M, Cohen ES, Jakes R, Cohen P |title=p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 95–9 |year= 1992 |pmid= 1330687 |doi=10.1016/0014-5793(92)81418-L }}
*{{cite journal | author=Goedert M, Cohen ES, Jakes R, Cohen P |title=p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 95–9 |year= 1992 |pmid= 1330687 |doi=10.1016/0014-5793(92)81418-L }}
Line 44: Line 45:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
{{PBB_Controls
| update_page = yes
| update_page = yes
| require_manual_inspection = no
| require_manual_inspection = no
| update_protein_box = yes
| update_protein_box = yes
| update_summary = yes
| update_summary = yes

Revision as of 05:23, 13 November 2010

Template:PBB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.[1]

Template:PBB Summary

Interactions

PPP2CB has been shown to interact with TLX1,[2] PPP2R1B[3] and PPP2R1A.[3][4]

See also

PPP2CA

References

  1. ^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively". Cytogenet Cell Genet. 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Kawabe, T (January 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615). ENGLAND: 454–8. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ a b Zhou, Jin (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. 369 (Pt 2). England: 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  4. ^ Goudreault, Marilyn (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1). United States: 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)

Further reading

Template:PBB Further reading

Template:PBB Controls


Stub icon

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=PPP2CB&oldid=396455143"