Neurokinin A: Difference between revisions
Content deleted Content added
No edit summary |
No edit summary |
||
| Line 45: | Line 45: | ||
}} |
}} |
||
'''Neurokinin A''' (formerly known as '''substance K''') is a member of the [[tachykinin]] family of [[neuropeptide]] [[neurotransmitters]]. It is produced from the same preprotachykinin A gene as the [[neuropeptide]] [[substance P]]. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the [[rat]] [[Colon (anatomy)|colon]] and bronchoconstriction through the [[Non-noradrenergic, non-cholinergic transmitter|non-adrenergic non-cholinergic nervous system]] (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K<ref>Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." ''Physiol Behav.'' 1993 Aug;54(2):249-58. PMID 7690487</ref>) and neuropeptide gamma are [[N terminus|N-terminally]] longer versions of neurokinin A, produced from the same [[splice form]]s of the same [[gene]], which appear to be final peptide products in some tissues.<ref name="Carter">Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." ''J Neurosci.'' 1990 Jul;10(7):2203-14. PMID 1695945</ref> |
'''Neurokinin A''' (formerly known as '''substance K''') is a member of the [[tachykinin]] family of [[neuropeptide]] [[neurotransmitters]]. It is produced from the same preprotachykinin A gene as the [[neuropeptide]] [[substance P]]. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the [[rat]] [[Colon (anatomy)|colon]] and bronchoconstriction through the [[Non-noradrenergic, non-cholinergic transmitter|non-adrenergic non-cholinergic nervous system]] (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K<ref>Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." ''Physiol Behav.'' 1993 Aug;54(2):249-58. PMID 7690487</ref>) and neuropeptide gamma are [[N terminus|N-terminally]] longer versions of neurokinin A, produced from the same [[splice form]]s of the same [[gene]], which appear to be final peptide products in some tissues.<ref name="Carter">Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." ''J Neurosci.'' 1990 Jul;10(7):2203-14. PMID 1695945</ref> |
||
Structure of Neurokinin A was obtained using CD spectropolarimetry and 2D proton NMR (pubmed reference). The structure was released on 16 December 2003. The protein was isolated from a mammalian source. Analysis showed 10 residues, 60% helical structure, and a formula weight of 1136.3. (PDB reference) |
|||
== References == |
== References == |
||
<references /> |
<references /> |
||
| Line 51: | Line 51: | ||
* {{cite journal |author=Regoli D, Boudon A, Fauchére J |title=Receptors and antagonists for substance P and related peptides |journal=Pharmacol Rev |volume=46 |issue=4 |pages=551–99 |year=1994 |pmid=7534932}} |
* {{cite journal |author=Regoli D, Boudon A, Fauchére J |title=Receptors and antagonists for substance P and related peptides |journal=Pharmacol Rev |volume=46 |issue=4 |pages=551–99 |year=1994 |pmid=7534932}} |
||
* Solution Structure of the Tachykinin Peptide Neurokinin A [http://www.pdb.org/pdb/explore/explore.do?structureId=1N6T] |
* Solution Structure of the Tachykinin Peptide Neurokinin A [http://www.pdb.org/pdb/explore/explore.do?structureId=1N6T] |
||
*Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles. [http://www.ncbi.nlm.nih.gov/pubmed/14645089?dopt=Abstract] |
|||
{{Tachykinins}} |
{{Tachykinins}} |
||
Revision as of 20:45, 21 November 2010
| tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Symbol | TAC1 | ||||||
| Alt. symbols | TAC2, NKNA | ||||||
| NCBI gene | 6863 | ||||||
| HGNC | 11517 | ||||||
| OMIM | 162320 | ||||||
| RefSeq | NM_013998 | ||||||
| UniProt | P20366 | ||||||
| Other data | |||||||
| Locus | Chr. 7 q21-q22 | ||||||
| |||||||
| |
| Identifiers | |
|---|---|
| MeSH | Neurokinin+A |
PubChem CID
|
|
| Properties | |
| C50H80N14O14S | |
| Molar mass | 1133.32 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Neurokinin A (formerly known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin A gene as the neuropeptide substance P. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the rat colon and bronchoconstriction through the non-adrenergic non-cholinergic nervous system (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K[1]) and neuropeptide gamma are N-terminally longer versions of neurokinin A, produced from the same splice forms of the same gene, which appear to be final peptide products in some tissues.[2] Structure of Neurokinin A was obtained using CD spectropolarimetry and 2D proton NMR (pubmed reference). The structure was released on 16 December 2003. The protein was isolated from a mammalian source. Analysis showed 10 residues, 60% helical structure, and a formula weight of 1136.3. (PDB reference)
References
- ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
- ^ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945
- Maggi C, Patacchini R, Rovero P, Giachetti A (1993). "Tachykinin receptors and tachykinin receptor antagonists". J Auton Pharmacol. 13 (1): 23–93. doi:10.1111/j.1474-8673.1993.tb00396.x. PMID 8382703.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Regoli D, Boudon A, Fauchére J (1994). "Receptors and antagonists for substance P and related peptides". Pharmacol Rev. 46 (4): 551–99. PMID 7534932.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Solution Structure of the Tachykinin Peptide Neurokinin A [1]
- Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles. [2]
.svg){kind=small} | This biochemistry article is a stub. You can help Wikipedia by expanding it. |