Phosphatidylethanolamine: Difference between revisions

Phosphatidylethanolamine
Names
	Other names cephalin
Identifiers
3D model (JSmol)	Interactive image;
ChemSpider	394115 ;
MeSH	phosphatidylethanolamines
PubChem CID	446872;
	InChI InChI=1S/C40H80NO8P/c1-3-5-7-9-11-13-15-17-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41)36-46-39(42)32-30-28-26-24-22-16-14-12-10-8-6-4-2/h38H,3-37,41H2,1-2H3,(H,44,45)/t38-/m1/s1 Key: NJGIRBISCGPRPF-KXQOOQHDSA-N ; InChI=1/C40H80NO8P/c1-3-5-7-9-11-13-15-17-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41)36-46-39(42)32-30-28-26-24-22-16-14-12-10-8-6-4-2/h38H,3-37,41H2,1-2H3,(H,44,45)/t38-/m1/s1 Key: NJGIRBISCGPRPF-KXQOOQHDBR;
	SMILES O=C(OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCCCC)COP(=O)(OCCN)O)CCCCCCCCCCCCCC;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

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Revision as of 16:33, 6 December 2010

Phosphatidylethanolamine (cephalin, sometimes abbreviated PE) is a lipid found in biological membranes. It is synthesized by the addition of CDP-ethanolamine to diglyceride, releasing CMP. S-adenosyl methionine can subsequently methylate the amine of phosphatidyl ethanolamine to yield phosphatidyl choline.

Cephalin is a phospholipid, which is a lipid derivative. It is not to be confused with the molecule of the same name that is an alkaloid constituent of Ipecac.

Function

Cephalin is found in all living cells, although in human physiology it is found particularly in nervous tissue such as the white matter of brain, nerves, neural tissue, and in spinal cord. Whereas lecithin is the principal phospholipid in animals, cephalin is the principal one in bacteria.

As a polar head group, phosphatidylethanolamine (PE) creates a more viscous lipid membrane compared to phosphatidylcholine (PC). For example, the melting temperature of di-oleoyl-PE is -16C while the melting temperature of di-oleoyl-PC is -20C. If the lipids had two palmitoyl chains, PE would melt at 63C while PC would melt already at 41C (See references in Wan et al. Biochemistry 47 2008). Lower melting temperatures correspond, in a simplistic view, to more fluid membranes.

Chemistry

In the chemical sense, cephalin is phosphatidylethanolamine. Like lecithin, it consists of a combination of glycerol esterified with two fatty acids and phosphoric acid. Whereas the phosphate group is combined with choline in Lecithin, it is combined with the ethanolamine in Cephalin.

The two fatty acids may be the same, or different, and are usually in the 1,2 positions (though can be in the 1,3 positions). Crazy People

External links

Cephalins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Additional images

References

This biochemistry article is a stub. You can help Wikipedia by expanding it.

@@ Line 43: / Line 43: @@
 In the chemical sense, cephalin is phosphatidylethanolamine. Like lecithin, it consists of a combination of [[glycerol]] esterified with two [[fatty acids]] and [[phosphoric acid]]. Whereas the phosphate group is combined with [[choline]] in Lecithin, it is combined with the [[ethanolamine]] in Cephalin.
-The two fatty acids may be the same, or different, and are usually in the 1,2 positions (though can be in the 1,3 positions).
+The two fatty acids may be the same, or different, and are usually in the 1,2 positions (though can be in the 1,3 positions). Crazy People
 ==External links==