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'''HU-308''' is a drug which acts as a [[cannabinoid]] [[agonist]]. It is highly selective for the [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptor]] subtype, with a selectivity of over 5000x for CB<sub>2</sub> vs CB<sub>1</sub>.<ref>{{Cite pmid|10588688}}</ref> The [[chemical synthesis|synthesis]] and characterization took place in the laboratory of Prof. [[Raphael Mechoulam|Mechoulam]] at the [[Hebrew University of Jerusalem]] in the late 1990s. It has [[analgesic]] effects,<ref>{{Cite pmid|16316653}}</ref> promotes proliferation of [[neural stem cells]],<ref>{{Cite pmid|17015409}}</ref> and protects both liver and blood vessel tissues against oxidative stress via inhibition of [[TNF-α]].<ref>{{Cite pmid|17652447}}</ref><ref>{{Cite pmid|17660390}}</ref> |
'''HU-308''' is a drug which acts as a [[cannabinoid]] [[agonist]]. It is highly selective for the [[cannabinoid receptor 2|CB<sub>2</sub>]] [[Receptor (biochemistry)|receptor]] subtype, with a selectivity of over 5000x for CB<sub>2</sub> vs CB<sub>1</sub>.<ref>{{Cite pmid|10588688}}</ref> The [[chemical synthesis|synthesis]] and characterization took place in the laboratory of Prof. [[Raphael Mechoulam|Mechoulam]] at the [[Hebrew University of Jerusalem]] in the late 1990s. It has [[analgesic]] effects,<ref>{{Cite pmid|16316653}}</ref> promotes proliferation of [[neural stem cells]],<ref>{{Cite pmid|17015409}}</ref> and protects both liver and blood vessel tissues against oxidative stress via inhibition of [[TNF-α]].<ref>{{Cite pmid|17652447}}</ref><ref>{{Cite pmid|17660390}}</ref> |
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==See also== |
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* [[HU-210]] |
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==References== |
==References== |
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{{reflist}} |
{{reflist}} |
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{{Cannabinoids}} |
{{Cannabinoids}} |
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[[Category:Cannabinoids]] |
[[Category:Cannabinoids]] |
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Revision as of 17:32, 9 December 2010
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| Chemical and physical data | |
| Formula | C27H43O2 |
| Molar mass | 414.621 g/mol g·mol−1 |
| 3D model (JSmol) | |
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HU-308 is a drug which acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1.[1] The synthesis and characterization took place in the laboratory of Prof. Mechoulam at the Hebrew University of Jerusalem in the late 1990s. It has analgesic effects,[2] promotes proliferation of neural stem cells,[3] and protects both liver and blood vessel tissues against oxidative stress via inhibition of TNF-α.[4][5]
See also
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10588688, please use {{cite journal}} with
|pmid=10588688instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16316653, please use {{cite journal}} with
|pmid=16316653instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17015409, please use {{cite journal}} with
|pmid=17015409instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17652447, please use {{cite journal}} with
|pmid=17652447instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17660390, please use {{cite journal}} with
|pmid=17660390instead.
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