OmrA-B RNA: Difference between revisions
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{{Rfam_box|acc=RF00079|image=RF00079.svg|description=SraE/RygA/RygB family RNA|abbreviation=SraE_RygA_RygB|type=Gene; sRNA;|avg_length=86.9|avg_identity=82|ss=Predicted; PFOLD|se=Bateman A|type=Gene; sRNA;}} |
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| Name = OmrA-B RNA |
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| image = OmrA-B RNA structure.png |
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| width = 276px |
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| caption = A representation of the bacterial OmrA-B [[Nucleic acid secondary structure|secondary structure]] including a colour scheme that indicates the degree of sequence conservation. |
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| Symbol = OmrA-B |
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| AltSymbols = OmrA, OmrB, SraE, RygA, RygB |
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| Rfam = RF00079 |
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| RNA_type = [[Gene]] |
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| Tax_domain = [[Bacteria]]; [[Enterobacteriaceae]] |
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The '''SraE RNA''' (also known as '''RygA''' and '''RygB''' and '''OmrA''' and '''OmrB''') is a small [[non-coding RNA]] that was discovered in ''E. coli'' during two large scale screens.<ref>{{cite journal | last = Argaman | first = L | coauthors = Hershberg R, Vogel J, Bejerano G, Wagner EG, Margalit H, Altuvia S | year = 2001 | title = Novel small RNA-encoding genes in the intergenic regions of Escherichia coli | journal = Curr Biol | volume = 11 | pages = 941–950 | pmid = 11448770 | doi = 10.1016/S0960-9822(01)00270-6 | issue = 12}}</ref><ref>{{cite journal | last = Wassarman | first = KM | coauthors = Repoila F, Rosenow C, Storz G, Gottesman S | year = 2001 | title = Identification of novel small RNAs using comparative genomics and microarrays | journal = Genes Dev | volume = 15 | pages = 1637–1651 | pmid = 11445539 | doi = 10.1101/gad.901001 | issue = 13 | pmc = 312727}}</ref> SraE is highly abundant in stationary phase, but low levels could be detected in exponentially growing cells as well. RygB is adjacent to RygA a closely related RNA. These RNAs bind to the [[Hfq protein]] and regulate [[gene expression]] by antisense binding. |
The '''SraE RNA''' (also known as '''RygA''' and '''RygB''' and '''OmrA''' and '''OmrB''') is a small [[non-coding RNA]] that was discovered in ''E. coli'' during two large scale screens.<ref>{{cite journal | last = Argaman | first = L | coauthors = Hershberg R, Vogel J, Bejerano G, Wagner EG, Margalit H, Altuvia S | year = 2001 | title = Novel small RNA-encoding genes in the intergenic regions of Escherichia coli | journal = Curr Biol | volume = 11 | pages = 941–950 | pmid = 11448770 | doi = 10.1016/S0960-9822(01)00270-6 | issue = 12}}</ref><ref>{{cite journal | last = Wassarman | first = KM | coauthors = Repoila F, Rosenow C, Storz G, Gottesman S | year = 2001 | title = Identification of novel small RNAs using comparative genomics and microarrays | journal = Genes Dev | volume = 15 | pages = 1637–1651 | pmid = 11445539 | doi = 10.1101/gad.901001 | issue = 13 | pmc = 312727}}</ref> SraE is highly abundant in stationary phase, but low levels could be detected in exponentially growing cells as well. RygB is adjacent to RygA a closely related RNA. These RNAs bind to the [[Hfq protein]] and regulate [[gene expression]] by antisense binding. |
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Revision as of 16:02, 4 February 2011
| OmrA-B RNA | |
|---|---|
 A representation of the bacterial OmrA-B secondary structure including a colour scheme that indicates the degree of sequence conservation. | |
| Identifiers | |
| Symbol | OmrA-B |
| Alt. Symbols | OmrA, OmrB, SraE, RygA, RygB |
| Rfam | RF00079 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Bacteria; Enterobacteriaceae |
| PDB structures | PDBe |
The SraE RNA (also known as RygA and RygB and OmrA and OmrB) is a small non-coding RNA that was discovered in E. coli during two large scale screens.[1][2] SraE is highly abundant in stationary phase, but low levels could be detected in exponentially growing cells as well. RygB is adjacent to RygA a closely related RNA. These RNAs bind to the Hfq protein and regulate gene expression by antisense binding. They negatively regulate the expression of several genes encoding outer membrane proteins, including cirA, fecA, fepA and ompT. Taken together, these data suggest that SraE participate in the regulation of outer membrane composition, responding to environmental conditions.[3]
References
- ^ Argaman, L (2001). "Novel small RNA-encoding genes in the intergenic regions of Escherichia coli". Curr Biol. 11 (12): 941–950. doi:10.1016/S0960-9822(01)00270-6. PMID 11448770.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Wassarman, KM (2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes Dev. 15 (13): 1637–1651. doi:10.1101/gad.901001. PMC 312727. PMID 11445539.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Guillier M, Gottesman S (2006). "Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs". Mol Microbiol. 59 (1): 231–47. doi:10.1111/j.1365-2958.2005.04929.x. PMID 16359331.
External links
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