Neuropeptide FF: Difference between revisions
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'''NPFF''' Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia. In humans, Neuropeptide FF peptides are encoded by the ''NPFF'' [[gene]]. Two genes encoding two different receptors (NPFF1 and NPFF2)and two precursors (NPFFA and NPFFB) have been cloned in several mammalian species. Processing of the NPFFA precursor at basic proteolytic sites should generate (i) a NPFF-containing peptide with three additional N-terminal amino acids different between species, and (ii) a NPSF (SLAAPQRFa)-containing peptide, the length of which depends on the species. NPFFB, identified as a precursor for RFamide-related peptides (RFR-P, also called GnIH for Gonadotropin inhibitory hormone), contains (i), a LPLRFa-containing peptide and (ii) a peptide sharing with NPFF the same C-terminal PQRFamide motif, such as NPVF (VPNLPQRFa) in human. |
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NPFF and opioid systems have been shown to interact at several levels, from animal behavior to receptor molecules. Nociception is the physiological function in which this interaction has been the most extensively studied but reward, locomotion, feeding and intestinal motility are also affected. Endogenous opioids are necessary for the analgesic properties of spinally injected NPFF while endogenous NPFF peptides are involved in the process of analgesic tolerance/hyperalgesia induced by chronic opioid treatment. |
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| ⚫ | <ref name="pmid9224703">{{cite journal | author = Perry SJ, Yi-Kung Huang E, Cronk D, Bagust J, Sharma R, Walker RJ, Wilson S, Burke JF | title = A human gene encoding morphine modulating peptides related to NPFF and FMRFamide | journal = FEBS Lett | volume = 409 | issue = 3 | pages = 426–30 | year = 1997 | month = Aug | pmid = 9224703 | pmc = | doi =10.1016/S0014-5793(97)00557-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPFF neuropeptide FF-amide peptide precursor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8620| accessdate = }}</ref> |
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| summary_text = NPFF protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. NPFF precursor encodes a preproprotein which is cleaved to form two active peptides with similar function.<ref name="entrez">{{cite web | title = Entrez Gene: NPFF neuropeptide FF-amide peptide precursor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8620| accessdate = }}</ref> |
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Revision as of 11:58, 7 April 2011
Template:PBB NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia. In humans, Neuropeptide FF peptides are encoded by the NPFF gene. Two genes encoding two different receptors (NPFF1 and NPFF2)and two precursors (NPFFA and NPFFB) have been cloned in several mammalian species. Processing of the NPFFA precursor at basic proteolytic sites should generate (i) a NPFF-containing peptide with three additional N-terminal amino acids different between species, and (ii) a NPSF (SLAAPQRFa)-containing peptide, the length of which depends on the species. NPFFB, identified as a precursor for RFamide-related peptides (RFR-P, also called GnIH for Gonadotropin inhibitory hormone), contains (i), a LPLRFa-containing peptide and (ii) a peptide sharing with NPFF the same C-terminal PQRFamide motif, such as NPVF (VPNLPQRFa) in human.
NPFF and opioid systems have been shown to interact at several levels, from animal behavior to receptor molecules. Nociception is the physiological function in which this interaction has been the most extensively studied but reward, locomotion, feeding and intestinal motility are also affected. Endogenous opioids are necessary for the analgesic properties of spinally injected NPFF while endogenous NPFF peptides are involved in the process of analgesic tolerance/hyperalgesia induced by chronic opioid treatment.
References
- ^ Perry SJ, Yi-Kung Huang E, Cronk D, Bagust J, Sharma R, Walker RJ, Wilson S, Burke JF (1997). "A human gene encoding morphine modulating peptides related to NPFF and FMRFamide". FEBS Lett. 409 (3): 426–30. doi:10.1016/S0014-5793(97)00557-7. PMID 9224703.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: NPFF neuropeptide FF-amide peptide precursor".
Further reading
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