REV1: Difference between revisions
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==Interactions== |
==Interactions== |
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REV1 has been shown to [[Protein-protein_interaction|interact]] with [[MAD2L2]].<ref name=pmid11485998>{{cite journal |last=Murakumo |first=Y |authorlink= |coauthors=Ogura Y, Ishii H, Numata S, Ichihara M, Croce C M, Fishel R, Takahashi M |year=[[2001]]|month=Sep. |title=Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 |journal=J. Biol. Chem. |volume=276 |issue=38 |pages=35644–51 |publisher= |location = United States| issn = 0021-9258| pmid = 11485998 |doi = 10.1074/jbc.M102051200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> It is believed that Rev1 may interact with PCNA, once ubiquitylated due to a lesion, and help recruit Pol ζ (Rev3/Rev7) a B family polymerase involved in TLS. |
REV1 has been shown to [[Protein-protein_interaction|interact]] with [[MAD2L2]].<ref name=pmid11485998>{{cite journal |last=Murakumo |first=Y |authorlink= |coauthors=Ogura Y, Ishii H, Numata S, Ichihara M, Croce C M, Fishel R, Takahashi M |year=[[2001]]|month=Sep. |title=Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 |journal=J. Biol. Chem. |volume=276 |issue=38 |pages=35644–51 |publisher= |location = United States| issn = 0021-9258| pmid = 11485998 |doi = 10.1074/jbc.M102051200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> It is believed that Rev1 may interact with PCNA, once ubiquitylated due to a lesion, and help recruit Pol ζ ([[REV3L|Rev3]]/Rev7) a B family polymerase involved in TLS. |
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==References== |
==References== |
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Revision as of 00:32, 24 May 2011
Template:PBB DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.[1][2] Template:PBB Summary Rev1 is a Y family DNA polymerase, it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine (dC) across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C.
Interactions
REV1 has been shown to interact with MAD2L2.[3] It is believed that Rev1 may interact with PCNA, once ubiquitylated due to a lesion, and help recruit Pol ζ (Rev3/Rev7) a B family polymerase involved in TLS.
References
- ^ Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z (1999). "The human REV1 gene codes for a DNA template-dependent dCMP transferase". Nucleic Acids Res. 27 (22): 4468–75. doi:10.1093/nar/27.22.4468. PMC 148731. PMID 10536157.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: REV1 REV1 homolog (S. cerevisiae)".
- ^ Murakumo, Y (2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38). United States: 35644–51. doi:10.1074/jbc.M102051200. ISSN 0021-9258. PMID 11485998.
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Further reading
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