Talk:Temporal lobe epilepsy

Contribution by 24.199.250.10

FYI- I am a Biology teacher in South Carolina and a cancer survivor. From age 13 through age 18 I exhibited the symptoms above. I was on the medication Tegretol for control of seizure symptoms and had a brain tumor removed at age 18 in 1990 by doctors at the University of Michigan hospital in Ann Arbor, Michigan. I hope you can use the information above for your site, as my classes have just found you so valuable as a reference. Please feel free to edit as needed. -Michelle McDaid

Reelin role in Temporal lobe epilepsy

Hello! I've been reading a lot lately about the reelin pathway and filling the data into the article, and stumbled on reelin's role in the granule cell dispersion (GCD) in T.L.Epilepsy. If you think it is right, you can take these findings from my reelin article and include them here. (Look in the reelin article, scroll down to the "role in pathology:Temporal Lobe Epilepsy" section) Best regards, --CopperKettle 07:16, 1 June 2006 (UTC)

Hi CopperKettle, I've been to the reelin page, and it does look like this might be a good link to TLE. I'll wait a day or two for feedback from some of the other editors, and then will start to add to and improve this. Do you have the pdfs of the original research you cite on this? If you do, would you mind sending them to edhubbard AT gmail DOT com (I'll also post this to your talk page)? Edhubbard 14:08, 16 August 2006 (UTC)

Reply (by CopperKettle)

Glad to hear that my work was useful, Edhubbard! I cite two papers, of which one is available only as an abstract: Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus, the other has a free full text online:Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy

Alas, I have no PDFs of the articles.

I'm not much savvy in the area of epilepsy, so I haven't really burrowed into these findings.. Maybe one should try searching PubMed with keywords like "reelin granule cell dispersion" or "reelin epilepsy". I'll try to, don't know when however. Best regards, --CopperKettle 14:36, 16 August 2006 (UTC)

P.S. Here's another free full text article:

* Reelin Controls Granule Cell Migration in the Dentate Gyrus by Acting on the Radial Glial Scaffold --CopperKettle 05:49, 17 August 2006 (UTC)

Finally made the changes to the article. --CopperKettle (talk) 06:27, 19 August 2008 (UTC)

Article content

As it currently stands, this article isn't a review of temporal lobe epilepsy; it's a hastily-thrown-together hodgepodge of information in support of some nutty theories which purport that religion is a by-product of epilepsy. The cautious reader is advised to take this article with a grain of salt. -ikkyu2 (talk) 22:10, 9 July 2006 (UTC)

Although the current page is somewhat of a mishmash, the connection between TLE and religiosity is actually pretty well established (see, e.g., Ramachandran and Blakeslee, 1998 for some discussion of this). I am currently working on Vilayanur S. Ramachandran and covering many of the unusual neurological effects that he looked at in his book, and came to this page. I'll try to clean it up, but it would be nice to know what the original author had in mind, as there are lots of good refs at the bottom that just aren't linked to in-text citations. Edhubbard 14:05, 16 August 2006 (UTC)

Personally, I'm more concerned that the "Treatments" section seems pretty POV. It comes out clearly biased against medical treatment, which may be fair enough, but still POV. Isn't it possible to point out that some people will do better without (or with low doses of) the meds, without making it look as if this is the case for everyone? Zuiram 22:14, 3 March 2007 (UTC)

I think the section may have been amended since you left that post, Zuiram. It comes across to me as an endorsement of surgery. I would appreciate it if other editors would keep an eye for neutral POV on this topic. Ikkyu2, I hope you are keeping mind that treatments for TLE is an emotional issue. People are always looking for the newer, more effective way to prevent seizures for the people they love, and if they find something that works, they want to get the word out. This page, or at least the section, may always be a hodgepodge.

I made a few edits to a section on driving privileges that appeared in the "symptoms" section. It probably belongs either in "treatment" or in its own section, but I tend not to make bold moves like moving from section to section. :) If someone else feels like doing so, I hope you will.Katharine908 (talk) 12:12, 4 April 2010 (UTC)

face-blindness?

There is a bunch of information on "face-blindness" under Resources but no mention of "face-blindness" throughout the entirety of this article. Why?

I agree, there is nothing that I can see linking TLE (which occurs mostly in the medial temporal lobe) with face-blindness, which is dependent on regions in the posterior inferior temporal lobe of what is known as the fusiform gyrus. I'll wait a few days for more comments, and if not, then I will remove these links, and start to clean up the entry. Edhubbard 14:05, 16 August 2006 (UTC)

I fixed this. ***Ria777 16:47, 6 September 2006 (UTC)

'Mesial'?

Do you mean 'medial' by any chance? 163.1.143.187 18:22, 31 May 2007 (UTC)

No, but it sure looks that way. People kept changing this, so there is now a comment you can see if you edit that section, the line looks like this:
:* [[Mesial<!--yes,mesial is the correct term here, please do not change it to medial-->''' temporal lobe'''
Cheers, CliffC 00:43, 1 June 2007 (UTC)

Recorrected it back to mesial...it looks like someone ignored the comment. It doesn't matter whether medial and mesial are arguably synonymous: virtually all the literature on epilepsy uses "mesial," so there's no reason for us to use a different term on Wikipedia until it becomes commonplace in the literature. Blahdenoma (talk) 05:56, 30 June 2011 (UTC)

Bipolar disiorder

This article and Bipolar disorder link to one another. Why? --Stlemur (talk) 16:24, 2 August 2008 (UTC)

Hippocampal sclerosis and gluten sensitivity

Interesting study at PMID 19244266 : association (7 of 16 folks with TLE+HS were gluten sensitive, none in the TLE-alone and control groups). --CopperKettle 09:41, 19 March 2009 (UTC)

Hey Copper, When I first saw your post, my first thought was "small sample statistics, watch out", but having read the abstract, that cites similar pathology in other cases of gluten sensitivity, I am a little more open to this possibly being a factor. I would still want to flag the small sample size, but given that there may be a clear mechanistic explanation here, it might be worth adding something about this. Cheers, Edhubbard (talk) 17:14, 19 March 2009 (UTC)

Thanks for the reply! I also wonder - whether the Mesial temporal sclerosis is different from hippocampal sclerosis. --CopperKettle 03:45, 21 March 2009 (UTC)

It is said here that the two terms are used more or less synonymously despite describing a bit different damage areas. --CopperKettle 05:14, 21 March 2009 (UTC)