CYP1B1: Difference between revisions
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*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=10.1080/004982598238868 }} |
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=10.1080/004982598238868 }} |
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*{{cite journal | author=Sasaki M, Kaneuchi M, Fujimoto S, ''et al.'' |title=CYP1B1 gene in endometrial cancer. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 171–6 |year= 2004 |pmid= 12770747 |doi= }} |
*{{cite journal | author=Sasaki M, Kaneuchi M, Fujimoto S, ''et al.'' |title=CYP1B1 gene in endometrial cancer. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 171–6 |year= 2004 |pmid= 12770747 |doi= 10.1016/S0303-7207(03)00079-0}} |
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*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 }} |
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 }} |
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*{{cite journal | author=Paracchini V, Raimondi S, Gram IT, ''et al.'' |title=Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. |journal=Am. J. Epidemiol. |volume=165 |issue= 2 |pages= 115–25 |year= 2007 |pmid= 17053044 |doi= 10.1093/aje/kwj365 }} |
*{{cite journal | author=Paracchini V, Raimondi S, Gram IT, ''et al.'' |title=Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. |journal=Am. J. Epidemiol. |volume=165 |issue= 2 |pages= 115–25 |year= 2007 |pmid= 17053044 |doi= 10.1093/aje/kwj365 }} |
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Revision as of 19:15, 13 August 2011
Template:PBB CYP1B1 belongs to the cytochrome P450 superfamily of enzymes.
Despite over 20 years of research of CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with CYP1A1. Despite this similarity, these two enzymes have very different catalytic efficiencies and metabolites when incubated with common substrates, such as retinoic acid and arachidonic acid. Recently CYP1B1 has been shown to be physiologically important in fetal development, since mutations in CYP1B1 are linked with a form of primary congenital glaucoma.
CYP1A1 and CYP1B1 are regulated by the Aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions in drug metabolism.
External links
- cytochrome+P-450+CYP1B1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- CYP1B1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma
References
Further reading
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